Kinetics of protein fibril formation: Methods and mechanisms

2017 ◽  
Vol 100 ◽  
pp. 3-10 ◽  
Author(s):  
E. Kiran Kumar ◽  
Neshatul Haque ◽  
N. Prakash Prabhu
Keyword(s):  
Fibril Formation ◽  
Protein Fibril ◽  
Kinetics Of

scholarly journals Effect of Association State and Conformational Stability on the Kinetics of Immunoglobulin Light Chain Amyloid Fibril Formation at Physiological pH

2002 ◽  
Vol 277 (15) ◽  
pp. 12657-12665 ◽  
Author(s):  
Pierre O. Souillac ◽  
Vladimir N. Uversky ◽  
Ian S. Millett ◽  
Ritu Khurana ◽  
Sebastian Doniach ◽  
...  
Keyword(s):  
Light Chain ◽  
Amyloid Fibril ◽  
Conformational Stability ◽  
Fibril Formation ◽  
Immunoglobulin Light Chain ◽  
Amyloid Fibril Formation ◽  
Kinetics Of ◽  
Association State

The Sulfate Moieties of Glycosaminoglycans Are Critical for the Enhancement of β-Amyloid Protein Fibril Formation

2001 ◽  
Vol 72 (4) ◽  
pp. 1681-1687 ◽  
Author(s):  
Gerardo M. Castillo ◽  
Widia Lukito ◽  
Thomas N. Wight ◽  
Alan D. Snow
Keyword(s):  
Fibril Formation ◽  
Amyloid Protein ◽  
Β Amyloid ◽  
Protein Fibril

Type IV collagen prevents amyloid β-protein fibril formation

Life Sciences ◽  
2002 ◽  
Vol 70 (13) ◽  
pp. 1555-1564 ◽  
Author(s):  
Yoichi Kiuchi ◽  
Yoshihiko Isobe ◽  
Kiyomi Fukushima
Keyword(s):  
Type Iv Collagen ◽  
Amyloid Β ◽  
Fibril Formation ◽  
Amyloid Β Protein ◽  
Type Iv ◽  
Β Protein ◽  
Protein Fibril

Early Kinetics of Amyloid Fibril Formation Reveals Conformational Reorganisation of Initial Aggregates

2007 ◽  
Vol 366 (4) ◽  
pp. 1351-1363 ◽  
Author(s):  
N. Cerdà-Costa ◽  
A. Esteras-Chopo ◽  
F.X. Avilés ◽  
L. Serrano ◽  
V. Villegas
Keyword(s):  
Amyloid Fibril ◽  
Fibril Formation ◽  
Amyloid Fibril Formation ◽  
Kinetics Of

Elucidating the Kinetics of β-Amyloid Fibril Formation

2005 ◽  
pp. 106-118 ◽  
Author(s):  
Nadia J. Edwin ◽  
Grigor B. Bantchev ◽  
Paul S. Russo ◽  
Robert P. Hammer ◽  
Robin L. McCarley
Keyword(s):  
Amyloid Fibril ◽  
Fibril Formation ◽  
Amyloid Fibril Formation ◽  
Β Amyloid ◽  
Kinetics Of

scholarly journals Inhibition of Protein Aggregation by Several Antioxidants

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Samra Hasanbašić ◽  
Alma Jahić ◽  
Selma Berbić ◽  
Magda Tušek Žnidarič ◽  
Eva Žerovnik
Keyword(s):  
Vitamin C ◽  
Protein Aggregation ◽  
Amyloid Fibril ◽  
Fibril Formation ◽  
Amyloid Fibril Formation ◽  
Transmission Electron ◽  
Tht Fluorescence ◽  
Shared Property ◽  
High Concentrations ◽  
Kinetics Of

Amyloid fibril formation is a shared property of all proteins; therefore, model proteins can be used to study this process. We measured protein aggregation of the model amyloid-forming protein stefin B in the presence and absence of several antioxidants. Amyloid fibril formation by stefin B was routinely induced at pH 5 and 10% TFE, at room temperature. The effects of antioxidants NAC, vitamin C, vitamin E, and the three polyphenols resveratrol, quercetin, and curcumin on the kinetics of fibril formation were followed using ThT fluorescence. Concomitantly, the morphology and amount of the aggregates and fibrils were checked by transmission electron microscopy (TEM). The concentration of the antioxidants was varied, and it was observed that different modes of action apply at low or high concentrations relative to the binding constant. In order to obtain more insight into the possible mode of binding, docking of NAC, vitamin C, and all three polyphenols was done to the monomeric form of stefin B.

Entactin-induced inhibition of human amyloid β-protein fibril formation in vitro

2001 ◽  
Vol 305 (2) ◽  
pp. 119-122 ◽  
Author(s):  
Yoichi Kiuchi ◽  
Yoshihiko Isobe ◽  
Kiyomi Fukushima
Keyword(s):  
Amyloid Β ◽  
Fibril Formation ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Protein Fibril
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