Conversion efficacy of intravenous ibutilide compared with intravenous amiodarone in patients with recent-onset atrial fibrillation and atrial flutter

2007 ◽  
Vol 118 (3) ◽  
pp. 321-325 ◽  
Author(s):  
Nikolaos V. Kafkas ◽  
Sotirios P. Patsilinakos ◽  
George A. Mertzanos ◽  
Kostas I. Papageorgiou ◽  
John I. Chaveles ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Atrial Flutter ◽  
Recent Onset ◽  
Intravenous Amiodarone ◽  
Onset Atrial Fibrillation

scholarly journals Efficacy of Wenxin Keli Plus Amiodarone versus Amiodarone Monotherapy in Treating Recent-Onset Atrial Fibrillation

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Nixiao Zhang ◽  
Gary Tse ◽  
Shristi Dahal ◽  
Yajuan Yang ◽  
Mengqi Gong ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Conversion Rate ◽  
Controlled Trial ◽  
Chinese Herb ◽  
Serious Adverse Events ◽  
Recent Onset ◽  
Intravenous Amiodarone ◽  
Conversion Time ◽  
To Receive ◽  
Onset Atrial Fibrillation

Background. Use of amiodarone (AMIO) in atrial fibrillation (AF) has significant side effects over prolonged periods. Wenxin Keli (WXKL), a Chinese herb extract, has been shown to be effective in atrial-selective inhibiting peak INa and hence beneficial in treating atrial arrhythmias, including atrial fibrillation. The aim of this randomized controlled trial was to evaluate potential effects of AMIO plus WXKL on conversion rate and time in patients with recent-onset AF. Methods. A total of 41 patients (71 ± 12 years, 44% male) with recent-onset (<48 h) AF eligible for conversion were randomized to receive either intravenous amiodarone (loading dose 5 mg/kg in 1 hour followed by 50 mg/h; n=21) or amiodarone with same dosage plus oral WXKL 18 g thrice daily (n=20) for 24 hours. Results. Conversion rate at 24 hours was of no difference between the two groups (75.0% vs. 81.0%, P=0.72); however, conversion time was markedly shorter in the AMIO + WXKL group compared to the AMIO group (291 ± 235 minutes vs. 725 ± 475 minutes, P=0.003). There were no serious adverse events during the study. Conclusion. Administration of amiodarone plus WXKL for recent-onset AF conversion was safe and effective, with faster sinus rhythm restoration compared with amiodarone alone.

Sign in / Sign up

Export Citation Format

Share Document