What Has Changed in European Concept of Undertaking? From „FENIN“ to „EASY PAY“

Competition is the main self-regulatory principle of the market in general, internal market included. Competition law has the form of general clauses making its application dependant on the correct interpretation of general concepts. Core competition rules of the Functional Treaty („TFEU“) are addressed to undertakings; undertaking thus belongs to key concepts of competition law. Interpretation of this concept is decisive for the scope of competition rules application. So, the article explores different approaches of the case law to the interpretation of the concept of undertaking based on economic activity. It compares the FENIN doctrine and the new functional test of separability developed in EASY PAY. It drives attention to the impact of this new test for the evaluation of procurement activities under competition scrutiny.

UK-wide study of the opinions of gastroenterology trainees: COVID-19, Shape of Training and the future workforce

IntroductionThe COVID-19 pandemic has disrupted training. Gastroenterology higher specialty training is soon to be reduced from 5 years to 4. The British Society of Gastroenterology Trainees Section biennial survey aims to delineate the impact of COVID-19 on training and the opinions on changes to training.MethodsAn electronic survey allowing for anonymised responses at the point of completion was distributed to all gastroenterology trainees from September to November 2020.ResultsDuring the first wave of the COVID-19 pandemic, 71.0% of the respondents stated that more than 50% of their clinical time was mostly within general internal medicine. Trainees reported a significant impact on all aspects of their gastroenterology training due to lost training opportunities and increasing service commitments. During the first wave, 88.5% of the respondents reported no access to endoscopy training lists. Since this time, 66.2% of the respondents stated that their endoscopy training lists had restarted. This has resulted in fewer respondents achieving endoscopy accreditation. The COVID-19 pandemic has caused 42.2% of the respondents to consider extending their training to obtain the skills required to complete training. Furthermore, 10.0% of the respondents reported concerns of a delay to completion of training. The majority of respondents (84.2%) reported that they would not feel ready to be a consultant after 4 years of training.ConclusionsReductions in all aspects of gastroenterology training were reported. This is mirrored in anticipated concerns about completion of training in a shorter training programme as proposed in the new curriculum. Work is now required to ensure training is restored following the pandemic.

Antibiotic prescribing patterns among patients admitted to an academic teaching hospital for COVID-19 during the first wave of the pandemic in Toronto: A retrospective, controlled study

Background: Empirical antibiotics are not recommended for coronavirus disease 2019 (COVID-19). Methods: In this retrospective study, patients admitted to Toronto General Hospital’s general internal medicine from the emergency department for COVID-19 between March 1 and August 31, 2020 were compared with those admitted for community-acquired pneumonia (CAP) in 2020 and 2019 in the same months. The primary outcome was antibiotics use pattern: prevalence and concordance with COVID-19 or CAP guidelines. The secondary outcome was antibiotic consumption in days of therapy (DOT)/100 patient-days. We extracted data from electronic medical records. We used logistic regression to model the association between disease and receipt of antibiotics, linear regression to compare DOT. Results: The COVID-19, CAP 2020, and CAP 2019 groups had 67, 73, and 120 patients, respectively. Median age was 71 years; 58.5% were male. Prevalence of antibiotic use was 70.2%, 97.3%, and 90.8% for COVID-19, CAP 2020, and CAP 2019, respectively. Compared with CAP 2019, the adjusted odds ratio (aOR) for receiving antibiotics was 0.23 (95% CI 0.10 to 0.53, p = 0.001) and 3.42 (95% CI 0.73 to 15.95, p = 0.117) for COVID-19 and CAP 2020, respectively. Among patients receiving antibiotics within 48 hours of admission, compared with CAP 2019, the aOR for guideline-concordant combination regimens was 2.28 (95% CI 1.08 to 4.83, p = 0.031) for COVID-19 and 1.06 (95% CI 0.55 to 2.05, p = 0.856) for CAP-2020. Difference in mean DOT/100 patient-days was –24.29 ( p = 0.009) comparing COVID-19 with CAP 2019, and +28.56 ( p = 0.003) comparing CAP 2020 with CAP 2019. Conclusions: There are opportunities for antimicrobial stewardship to address unnecessary antibiotic use.

Enhancing existing medical school curricula with an innovative healthcare disparities curriculum

Background Effective healthcare disparities curricula seek to train physicians who are well equipped to address the health needs of an increasingly diverse society. Current literature on healthcare disparities curricula and implementation focuses on courses created independent of existing educational materials. Our aim was to develop and implement a novel resource-conserving healthcare disparities curriculum to enhance existing medical school lectures without the need for additional lectures. Methods This non-randomized intervention was conducted at the University of California Los Angeles. The curriculum was offered to all first-year medical students in the class of 2021 (n=188). With institutional approval, a new healthcare disparities curriculum was created based on the Society of General Internal Medicine’s core learning objectives for effective healthcare disparities curricula (J General Internal Med 25:S160–163, 2010). Implementation of the curriculum made use of “teachable moments” within existing medical school lectures. Teachable moments were broad lecture topics identified by the research team as suitable for introducing relevant healthcare disparities content. The new lecture-enhancing healthcare disparities curriculum was delivered with the related lecture via integrated PDF documents uploaded to an online learning management system. Students were encouraged to complete pre- and post- course assessments to examine changes in disparities knowledge and self-rated confidence in addressing disparities. Matched χ2 tests were used for statistical analysis. Results Participating students (n=92) completed both pre- and post-course assessments and were retrospectively stratified, based on self-reported use of the new lecture enhancing curriculum, into the “high utilizer” group (use of materials “sometimes” or “very often,” n=52) and the comparison “low utilizer” group (use of the materials “rarely” or “very rarely,” n=40). Students who self-identified as underrepresented racial and ethnic minorities in medicine were more likely to utilize the material (41% of the high utilizers vs. 17% of the low utilizer group, p<.01). Post-course knowledge assessment scores and self-reported confidence in addressing healthcare disparities improved only in the high utilizer group. Conclusions Integrating new guideline based curricula content simultaneously into pre-existing lectures by identifying and harnessing teachable moments may be an effective and resource-conserving strategy for enhancing healthcare disparities education among first year medical students.

The Modified Mini Mental State (3MS) Test - Development of an Online Training Program

The Modified Mini Mental State (3MS), a screening test for cognitive abilities, can be administered in approximately 10 minutes and has a score range of 0-100. Early detection of cognitive impairment is important for clinical care. An individual’s score change over time can also help assess disease progression and treatment effects. The Web of Science, an online database, reports 1,864 publications using the 3MS, including 412 in the last 5 years. Articles came from 52 countries in 7 continents, with languages in English (98.7%), French (0.5%), Spanish (0.5%), German (0.2%), Czech (0.1%), and Korean (0.1%). The fields that publish with 3MS data included Geriatrics/Gerontology, Neurosciences/Neurology, Psychiatry, Psychology, and General/Internal Medicine. One reason for the popularity of the 3MS is its detailed manual for test administering and scoring; however, to date the manual is available only in print form. Here we present an online training program. It includes detailed directions on administering and scoring, video of a 3MS administration, and post-training tests on a trainee’s competency. This training material also covers clinical benefits of cognitive screening and a comparison of the 3MS with other measures. The 3MS helps clinicians with early detection of cognitive impairment, allowing time to address its underlying and potentially reversible causes, and aids in disease management. This online training program will help ensure accuracy and reduce between-tester variability of the obtained scores in both clinical care and research studies.

POCUS Evaluation in Acute Kidney Injury

Acute kidney injury is a common clinical problem encountered in general internal medicine. The evaluation of acute kidney injury is mainly driven by the patient’s clinical history, physical exam and basic urinary/laboratory investigation. Point of care ultrasound (POCUS) may be a useful tool to help clinicians to narrow and/or prioritize differential diagnosis in patients presenting with acute kidney injury. Here we present a case of a 67-year old male presenting with dysuria, fevers, and flank pain along with elevation in serum creatinine who was admitted for acute kidney injury secondary to complicated urinary tract infection. Subsequent renal POCUS showed bilateral anechoic fluid collection within the renal sinus with dilated calyces suggestive of bilateral hydronephrosis most likely due to a new diagnosis of benign prostatic hyperplasia. This case demonstrates the use of POCUS added valuable diagnostic information and therapeutic management for this patient presenting with acute kidney injury.

Sex Differences in Anemia and Red Blood Cell Transfusions Among General Internal Medicine Inpatients

Background: Epidemiological data from the general population have shown that women have lower hemoglobin values compared to men. Previous research on surgical patients showed that women were significantly more likely to receive red blood cell (RBC) transfusions compared to men in the peri-operative period due to multiple factors including the application of absolute transfusion thresholds. Sex differences in RBC transfusion frequencies have not been well studied in non-surgical settings. Here we investigated sex differences in anemia and in RBC transfusion frequencies in patients admitted to General Internal Medicine (GIM) wards. Study design and methods: This was a retrospective cohort study using de-identified electronic patient data from all patients admitted to the GIM wards from the emergency department across 4 different hospitals between 2010 and 2017, who had at least 1 CBC test during their admission. Patients with multiple hospital admissions during the study period, those who were pregnant, those who underwent surgery during the admission, and those transferred to or from another service besides GIM during their admission were excluded. Severity of anemia was stratified using the WHO sex-specific quantitative thresholds for hemoglobin: mild anemia (110 to 119 g/L in women and 110 to 129 g/L in men), moderate anemia (80 to 109 g/L in both men and women) and severe anemia (lower than 80 g/L in both men and women). Results: The study cohort consisted of 51,073 inpatients (24,666 men and 26,407 women). The median hemoglobin at the time of admission was significantly higher (p &lt; 0.001) in men (median 135 g/L, IQR 31) compared to women (median 127 g/L, IQR 25). The prevalence of moderate and severe anemia was significantly higher (p &lt; 0.001) in female inpatients (56%) compared to males (44%). The proportion of patients who received RBC transfusions during their admission was not significantly different (p = 0.36) between men (49%) and women (51%). There was no significant sex difference (p = 0.28) observed in the median hemoglobin prior to RBC transfusions between men (median 68 g/L, IQR 10.5) and women (median 68 g/L, IQR 11). The number of patients with pre-transfusion hemoglobin less than 70 g/L, the commonly used threshold for transfusion in the in-patient setting, was not significantly different (p = 0.91) between men and women. However, among the patients with hemoglobin &lt; 70 g/L, a significantly lower proportion (p &lt; 0.001) of women (82%) received RBC transfusions compared to men (91%). Conclusions: In a large cohort of GIM inpatients, we observed significantly higher prevalence of moderate and severe anemia in women compared to men. While there was no sex difference in overall RBC transfusion frequencies in this inpatient population, there was a lower proportion of women receiving RBC transfusions compared to men in the subgroup of patients with hemoglobin less than 70 g/L. Disclosures No relevant conflicts of interest to declare.