scholarly journals Association between serum anti-glycopeptidolipid-core IgA antibody titers and clinical characteristics of Mycobacterium avium complex pulmonary disease

2021 ◽  
Author(s):  
Norio Kodaka ◽  
Chihiro Nakano ◽  
Takeshi Oshio ◽  
Kayo Watanabe ◽  
Kumiko Niitsuma ◽  
...  
Keyword(s):  
Pulmonary Disease ◽  
Mycobacterium Avium ◽  
Clinical Characteristics ◽  
Mycobacterium Avium Complex ◽  
Antibody Titers ◽  
Iga Antibody

scholarly journals Association between Serum Anti-glycopeptidolipid-core IgA Antibody Titers and Clinical Characteristics of Mycobacterium Avium Complex Pulmonary Disease

2021 ◽  
Author(s):  
Norio Kodaka ◽  
Chihiro Nakano ◽  
Takeshi Oshio ◽  
Kayo Watanabe ◽  
Kumiko Niitsuma ◽  
...  
Keyword(s):  
Pulmonary Disease ◽  
Mycobacterium Avium ◽  
Clinical Characteristics ◽  
Positive Group ◽  
Treatment And Prevention ◽  
Positive Antibody ◽  
Mycobacterial Diseases ◽  
Iga Antibodies ◽  
Antibody Titers ◽  
Iga Antibody

Abstract Mycobacterium avium complex pulmonary disease (MAC-PD) can be serologically diagnosed according to the presence of anti-glycopeptidolipid (GPL)-core IgA antibodies. However, few studies have examined the association between serum anti-GPL-core IgA antibody titers and the clinical characteristics of patients with MAC-PD. From April 2014 to June 2019, we determined the level of anti-GPL-core IgA antibodies in 489 MAC-PD patients at our institute. Of them, 89 patients fulfilled the criteria of the American Thoracic Society and the Infectious Diseases Society of America statement on the diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. These patients were divided into antibody-positive (n = 59) or -negative (n = 30) groups according to their serum anti-GPL-core IgA antibody results. Additionally, the positive antibody group was further divided into a strong positive group (n = 27) and a weak positive group (n = 32), and their clinical characteristics were retrospectively compared. Disease progression requiring treatment during the 12 months following diagnosis and extensive radiological findings were significantly abundant in the strong positive group compared with the weak positive group. Our findings revealed that serum anti-GPL-core IgA antibody titers are useful not only for diagnosing MAC-PD but also for predicting the risk of exacerbation.

Clinical Characteristics of the Patients with Mycobacterium avium Complex Pulmonary Disease

2003 ◽  
Vol 54 (1) ◽  
pp. 33 ◽  
Author(s):  
Won Jung Koh ◽  
O Jung Kwon ◽  
Eun Hae Kang ◽  
Ik Soo Jeon ◽  
Yu Jang Pyun ◽  
...  
Keyword(s):  
Pulmonary Disease ◽  
Mycobacterium Avium ◽  
Clinical Characteristics ◽  
Mycobacterium Avium Complex

The Expanding Spectrum of Mycobacterium avium Complex-Associated Pulmonary Disease

CHEST Journal ◽  
2006 ◽  
Vol 130 (4) ◽  
pp. 1234-1241 ◽  
Author(s):  
E. Andrew Waller ◽  
Archana Roy ◽  
Lisa Brumble ◽  
Andras Khoor ◽  
Margaret M. Johnson ◽  
...  
Keyword(s):  
Pulmonary Disease ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex

hsa-miR-346 is a potential serum biomarker of Mycobacterium avium complex pulmonary disease activity

2017 ◽  
Vol 23 (10) ◽  
pp. 703-708 ◽  
Author(s):  
Tomoyasu Nishimura ◽  
Eiko Tamizu ◽  
Shunsuke Uno ◽  
Yoshifumi Uwamino ◽  
Hiroshi Fujiwara ◽  
...  
Keyword(s):  
Disease Activity ◽  
Pulmonary Disease ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Serum Biomarker

Treatment of Mycobacterium avium Complex (MAC) Pulmonary Disease

2004 ◽  
Vol 57 (3) ◽  
pp. 234 ◽  
Author(s):  
Won Jung Koh ◽  
O Jung Kwon ◽  
Eun Hae Kang ◽  
Gee Young Suh ◽  
Man Pyo Chung ◽  
...  
Keyword(s):  
Pulmonary Disease ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex
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