Challenges in replicating secondary analysis of electronic health records data with multiple computable phenotypes: a case study on methicillin-resistant Staphylococcus aureus bacteremia infections

Author(s):  
Inyoung Jun ◽  
Shannan N. Rich ◽  
Zhaoyi Chen ◽  
Jiang Bian ◽  
Mattia Prosperi
Author(s):  
Gabrielle M. Gussin ◽  
Lauren Heim ◽  
Thomas Tjoa ◽  
James A. McKinnell ◽  
Loren G. Miller ◽  
...  

Abstract The CLEAR Trial recently found that decolonization reduced infections and hospitalizations in MRSA carriers in the year following hospital discharge. In this secondary analysis, we explored whether decolonization had a similar benefit in the subgroup of trial participants who harbored USA300, using two different definitions for the USA300 strain-type.


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