Mucormycoses: serious complication of high-dose corticosteroid therapy for traumatic optic neuropathy

2008 ◽  
Vol 37 (4) ◽  
pp. 391-394 ◽  
Author(s):  
I. Dojcinovic ◽  
M. Richter
Keyword(s):  
Corticosteroid Therapy ◽  
Optic Neuropathy ◽  
High Dose ◽  
Traumatic Optic Neuropathy ◽  
High Dose Corticosteroid ◽  
Dose Corticosteroid

The Effects of High-Dose Corticosteroid Therapy on Optic Nerve Head Blood Flow in Experimental Traumatic Optic Neuropathy

1999 ◽  
Vol 31 (6) ◽  
pp. 463-470 ◽  
Author(s):  
Helen Lew ◽  
Sang Yeul Lee ◽  
Jae Woo Jang ◽  
Hye Young Kim ◽  
Shin Jeong Kang ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Corticosteroid Therapy ◽  
Optic Neuropathy ◽  
Optic Nerve Head ◽  
High Dose ◽  
Traumatic Optic Neuropathy ◽  
High Dose Corticosteroid ◽  
Dose Corticosteroid

scholarly journals A Systematic Literature Review on Traumatic Optic Neuropathy

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Saeed Karimi ◽  
Amir Arabi ◽  
Iman Ansari ◽  
Toktam Shahraki ◽  
Sare Safi
Keyword(s):  
Optic Nerve ◽  
Head Trauma ◽  
Optic Neuropathy ◽  
High Dose ◽  
Traumatic Optic Neuropathy ◽  
Efficient Treatment ◽  
High Dose Corticosteroid ◽  
Pupillary Constriction ◽  
Dose Corticosteroid ◽  
Mechanical Shearing

Traumatic optic neuropathy (TON) is an uncommon vision-threatening disorder that can be caused by ocular or head trauma and is categorized into direct and indirect TON. The overall incidence of TON is 0.7–2.5%, and indirect TON has a higher prevalence than direct TON. Detection of an afferent pupillary defect in the presence of an intact globe in a patient with ocular or head trauma with decreased visual acuity strongly suggests TON. However, afferent pupillary defects may be difficult to detect in patients who have received narcotics that cause pupillary constriction and in those with bilateral TON. Mechanical shearing of the optic nerve axons and contusion necrosis due to immediate ischemia from damage to the optic nerve microcirculation and apoptosis of neurons is a probable mechanism. The proper management of TON is controversial. High-dose corticosteroid therapy and decompression of the optic nerve provide no additional benefit over observation alone. Intravenous erythropoietin may be a safe and efficient treatment for patients with TON.

Sustained hemostatic abnormality in patients with steroid-induced osteonecrosis in the early period after high-dose corticosteroid therapy

2000 ◽  
Vol 5 (4) ◽  
pp. 374-379 ◽  
Author(s):  
Kazuhiro Oinuma ◽  
Yoshitada Harada ◽  
Yasushi Nawata ◽  
Katsuhiko Takabayashi ◽  
Isao Abe ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Early Period ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Dose Corticosteroid

Ethosuximide-induced Stevens-Johnson syndrome: Beneficial effect of early intervention with high-dose corticosteroid therapy

2018 ◽  
Vol 45 (5) ◽  
pp. 592-595 ◽  
Author(s):  
Kota Tachibana ◽  
Toshihisa Hamada ◽  
Hiroki Tsuchiya ◽  
Takashi Shibata ◽  
Kazuyasu Fujii ◽  
...  
Keyword(s):  
Early Intervention ◽  
Beneficial Effect ◽  
Corticosteroid Therapy ◽  
Stevens Johnson Syndrome ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Johnson Syndrome ◽  
Dose Corticosteroid

Bone Complications of Corticosteroids

1996 ◽  
Vol 1 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Robert S. Lester
Keyword(s):  
Corticosteroid Therapy ◽  
Low Dose ◽  
Treatment Options ◽  
Osteoporotic Fractures ◽  
High Dose ◽  
Systemic Complications ◽  
High Dose Corticosteroid ◽  
Systemic Corticosteroids ◽  
Dose Corticosteroid ◽  
Bone Complications

Background: Systemic corticosteroids, a mainstay of treatment for severe dermatosis, are associated with systemic complications. Adverse effects of corticosteroids to bone represent a significant adverse effect that, is poorly understood and poorly managed. Objectives: The purpose of this article is to educate dermatologists to the current understanding of the pathogenesis, diagnosis, and treatment options available for bone complications of corticosteroids. Results: Virtually all patients chronically exposed to high-dose corticosteroid therapy lose bone mass and are at risk for osteoporotic fractures. In addition, osteonecrosis is an unpredictable complication of corticosteroid therapy that may occur with even low-dose corticosteroids. Conclusion: Optimal risk management of corticosteroid therapy includes understanding the risk factors associated with bone complications and improving communication with patients.

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