Bone Complications of Corticosteroids

1996 ◽  
Vol 1 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Robert S. Lester
Keyword(s):  
Corticosteroid Therapy ◽  
Low Dose ◽  
Treatment Options ◽  
Osteoporotic Fractures ◽  
High Dose ◽  
Systemic Complications ◽  
High Dose Corticosteroid ◽  
Systemic Corticosteroids ◽  
Dose Corticosteroid ◽  
Bone Complications

Background: Systemic corticosteroids, a mainstay of treatment for severe dermatosis, are associated with systemic complications. Adverse effects of corticosteroids to bone represent a significant adverse effect that, is poorly understood and poorly managed. Objectives: The purpose of this article is to educate dermatologists to the current understanding of the pathogenesis, diagnosis, and treatment options available for bone complications of corticosteroids. Results: Virtually all patients chronically exposed to high-dose corticosteroid therapy lose bone mass and are at risk for osteoporotic fractures. In addition, osteonecrosis is an unpredictable complication of corticosteroid therapy that may occur with even low-dose corticosteroids. Conclusion: Optimal risk management of corticosteroid therapy includes understanding the risk factors associated with bone complications and improving communication with patients.

Efficacy of Low-Dose Corticosteroid Therapy Versus High-Dose Corticosteroid Therapy in Bell’s Palsy in Children

2016 ◽  
Vol 32 (1) ◽  
pp. 72-75 ◽  
Author(s):  
Pinar Arican ◽  
Nihal Olgac Dundar ◽  
Pinar Gencpinar ◽  
Dilek Cavusoglu
Keyword(s):  
Corticosteroid Therapy ◽  
Low Dose ◽  
Oral Prednisolone ◽  
Bell’S Palsy ◽  
High Dose ◽  
Facial Nerve Paralysis ◽  
Bell's Palsy ◽  
Nerve Paralysis ◽  
High Dose Corticosteroid ◽  
Dose Corticosteroid

Bell’s palsy is the most common cause of acute peripheral facial nerve paralysis, but the optimal dose of corticosteroids in pediatric patients is still unclear. This retrospective study aimed to evaluate the efficacy of low-dose corticosteroid therapy compared with high-dose corticosteroid therapy in children with Bell’s palsy. Patients were divided into 2 groups based on the dose of oral prednisolone regimen initiated. The severity of idiopathic facial nerve paralysis was graded according to the House-Brackmann Grading Scale. The patients were re-assessed in terms of recovery rate at the first, third, and sixth months of treatment. There was no significant difference in complete recovery between the 2 groups after 1, 3, and 6 months of treatment. In our study, we concluded that even at a dose of 1 mg/kg/d, oral prednisolone was highly effective in the treatment of Bell’s palsy in children.

Sustained hemostatic abnormality in patients with steroid-induced osteonecrosis in the early period after high-dose corticosteroid therapy

2000 ◽  
Vol 5 (4) ◽  
pp. 374-379 ◽  
Author(s):  
Kazuhiro Oinuma ◽  
Yoshitada Harada ◽  
Yasushi Nawata ◽  
Katsuhiko Takabayashi ◽  
Isao Abe ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Early Period ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Dose Corticosteroid

Ethosuximide-induced Stevens-Johnson syndrome: Beneficial effect of early intervention with high-dose corticosteroid therapy

2018 ◽  
Vol 45 (5) ◽  
pp. 592-595 ◽  
Author(s):  
Kota Tachibana ◽  
Toshihisa Hamada ◽  
Hiroki Tsuchiya ◽  
Takashi Shibata ◽  
Kazuyasu Fujii ◽  
...  
Keyword(s):  
Early Intervention ◽  
Beneficial Effect ◽  
Corticosteroid Therapy ◽  
Stevens Johnson Syndrome ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Johnson Syndrome ◽  
Dose Corticosteroid

Myelofibrosis and Systemic Lupus erythematosus: Reversal of Fibrosis with High-Dose Corticosteroid Therapy

1992 ◽  
Vol 88 (1) ◽  
pp. 32-36 ◽  
Author(s):  
Yasushi Inoue ◽  
Atsushi Matsubara ◽  
Shigeru Okuya ◽  
Koichiro Okafuji ◽  
Kohei Kaku ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Corticosteroid Therapy ◽  
Lupus Erythematosus ◽  
High Dose ◽  
Systemic Lupus ◽  
High Dose Corticosteroid ◽  
Dose Corticosteroid
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