A study on pathogenicity and mosquito transmission success in the rodent malaria parasite Plasmodium chabaudi adami

2009 ◽  
Vol 39 (3) ◽  
pp. 347-354 ◽  
Author(s):  
Naomi Gadsby ◽  
Richard Lawrence ◽  
Richard Carter
Keyword(s):  
Malaria Parasite ◽  
Plasmodium Chabaudi ◽  
Rodent Malaria Parasite ◽  
Rodent Malaria ◽  
Transmission Success ◽  
Parasite Plasmodium

scholarly journals Plasmodium-specific atypical memory B cells are short-lived activated B cells

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Damián Pérez-Mazliah ◽  
Peter J Gardner ◽  
Edina Schweighoffer ◽  
Sarah McLaughlin ◽  
Caroline Hosking ◽  
...  
Keyword(s):  
B Cells ◽  
Heavy Chain ◽  
Chronic Infection ◽  
Malaria Parasite ◽  
Memory B Cells ◽  
Plasmodium Chabaudi ◽  
Rodent Malaria Parasite ◽  
Chronic Infections ◽  
Rodent Malaria ◽  
Parasite Plasmodium

A subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been suggested these cells are exhausted long-lived memory B cells, and their accumulation may contribute to poor acquisition of long-lasting immunity to certain chronic infections, such as malaria and HIV. Here, we generated an immunoglobulin heavy chain knock-in mouse with a BCR that recognizes MSP1 of the rodent malaria parasite, Plasmodium chabaudi. In combination with a mosquito-initiated P. chabaudi infection, we show that Plasmodium-specific atypical memory B cells are short-lived and disappear upon natural resolution of chronic infection. These cells show features of activation, proliferation, DNA replication, and plasmablasts. Our data demonstrate that Plasmodium-specific atypical memory B cells are not a subset of long-lived memory B cells, but rather short-lived activated cells, and part of a physiologic ongoing B-cell response.

scholarly journals Transformation of the rodent malaria parasite Plasmodium chabaudi

2011 ◽  
Vol 6 (4) ◽  
pp. 553-561 ◽  
Author(s):  
Philip J Spence ◽  
Deirdre Cunningham ◽  
William Jarra ◽  
Jennifer Lawton ◽  
Jean Langhorne ◽  
...  
Keyword(s):  
Malaria Parasite ◽  
Plasmodium Chabaudi ◽  
Rodent Malaria Parasite ◽  
Rodent Malaria ◽  
Parasite Plasmodium

scholarly journals Lys48 ubiquitination during the intraerythrocytic cycle of the rodent malaria parasite, Plasmodium chabaudi

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0176533 ◽  
Author(s):  
Lorena González-López ◽  
Rebeca Carballar-Lejarazú ◽  
Gerardo Arrevillaga Boni ◽  
Leticia Cortés-Martínez ◽  
Febe Elena Cázares-Raga ◽  
...  
Keyword(s):  
Malaria Parasite ◽  
Plasmodium Chabaudi ◽  
Rodent Malaria Parasite ◽  
Rodent Malaria ◽  
Parasite Plasmodium

scholarly journals Mosquito transmission of the rodent malaria parasite Plasmodium chabaudi

2012 ◽  
Vol 11 (1) ◽  
Author(s):  
Philip J Spence ◽  
William Jarra ◽  
Prisca Lévy ◽  
Wiebke Nahrendorf ◽  
Jean Langhorne
Keyword(s):  
Malaria Parasite ◽  
Plasmodium Chabaudi ◽  
Rodent Malaria Parasite ◽  
Rodent Malaria ◽  
Parasite Plasmodium
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