Biologically Effective Dose–Response Relationship for Breast Cancer Treated by Conservative Surgery and Postoperative Radiotherapy

2009 ◽  
Vol 75 (2) ◽  
pp. 512-517 ◽  
Author(s):  
George A. Plataniotis ◽  
Roger G. Dale
Keyword(s):  
Breast Cancer ◽  
Effective Dose ◽  
Dose Response ◽  
Postoperative Radiotherapy ◽  
Conservative Surgery ◽  
Biologically Effective Dose ◽  
Response Relationship ◽  
Dose Response Relationship

Treatment of advanced breast cancer with tamoxifen: Evaluation of the dose-response relationship at two dose levels

1982 ◽  
Vol 2 (4) ◽  
pp. 395-400 ◽  
Author(s):  
Carsten Rose ◽  
Karen Theilade ◽  
Else Boesen ◽  
Marianne Salimtschik ◽  
Per Dombernowsky ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Dose Response ◽  
Advanced Breast ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Dose Levels

The Effects of Changes in the Rate of Infusion of Vasopressin in Anesthetized Dogs

1971 ◽  
Vol 49 (11) ◽  
pp. 933-940 ◽  
Author(s):  
J. M. Mason ◽  
J. R. Ledsome
Keyword(s):  
Effective Dose ◽  
Dose Rate ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Water Diuresis ◽  
Experimental Procedure ◽  
Anesthetic Agents ◽  
Anesthetized Dogs ◽  
Urine Formation

The dose rate of infusion of vasopressin which can be expected to provide maximal effects upon urine formation is difficult to predict in anesthetized dogs. The anesthetic agents, the state of hydration, and the osmolal excretion may all influence the effectiveness of vasopressin. The experiments demonstrate that in moderately hydrated anesthetized dogs when the rate of vasopressin infusion is changed from 0.4 to 0.04 mU/kg min−1 there is a transient dilution of the urine. The lower dose of vasopressin is four times that which completely inhibits water diuresis in conscious dogs and is larger than the dose of 0.025 mU/kg min−1 used in many experiments on anesthetized dogs to eliminate the effects of antidiuretic hormone on the kidney. It appears necessary in experiments in which an attempt is made to eliminate or to assess the effects of vasopressin upon a mechanism producing diuresis either to establish a maximum effective dose for the particular experimental cirmustances, or to examine the dose–response relationship between vasopressin and the diuresis in the particular experimental procedure.

Sign in / Sign up

Export Citation Format

Share Document