Palliative Radiation Therapy for Painful Bone Metastases From Solid Tumors Delivered With Static Ports of Tomotherapy

2014 ◽  
Vol 90 (1) ◽  
pp. S694
Author(s):  
P. Franco ◽  
F. Migliaccio ◽  
P. Torielli ◽  
C. Arrichiello ◽  
A. Peruzzo Cornetto ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Bone Metastases ◽  
Solid Tumors ◽  
Palliative Radiation ◽  
Palliative Radiation Therapy ◽  
Painful Bone Metastases

scholarly journals EP-1400: Quality of Life in Responders after Palliative Radiation Therapy for Painful Bone Metastases

2017 ◽  
Vol 123 ◽  
pp. S748
Author(s):  
L.C. Mendez ◽  
J.L. Padilha ◽  
K.M. Lima ◽  
E. Chow ◽  
F.Y. Moraes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Bone Metastases ◽  
Palliative Radiation ◽  
Palliative Radiation Therapy ◽  
Painful Bone Metastases

scholarly journals Efficacy of 8 Gy Single Fraction Palliative Radiation Therapy in Painful Bone Metastases: A Single Institution Experience

Cureus ◽  
2018 ◽  
Author(s):  
Muhammad Shuja ◽  
Ayman A Elghazaly ◽  
Asif Iqbal ◽  
Reham Mohamed ◽  
Amal Marie ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Bone Metastases ◽  
Single Institution ◽  
Single Fraction ◽  
Palliative Radiation ◽  
Palliative Radiation Therapy ◽  
Painful Bone Metastases

PD-0886 30-Day Mortality after Palliative Radiation Therapy for Painful Bone Metastases

2021 ◽  
Vol 161 ◽  
pp. S724-S725
Author(s):  
M. Vázquez Varela ◽  
A.A. Geng ◽  
J. Garre ◽  
E. Recalde ◽  
M. Altabas ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Bone Metastases ◽  
Palliative Radiation ◽  
Palliative Radiation Therapy ◽  
Painful Bone Metastases

Quality of life in responders after palliative radiation therapy for painful bone metastases using EORTC QLQ-C30 and EORTC QLQ-BM22: results of a Brazilian cohort

2017 ◽  
Vol 6 (S1) ◽  
pp. S65-S70 ◽  
Author(s):  
Lucas C. Mendez ◽  
Srinivas Raman ◽  
Bo Angela Wan ◽  
José Luiz Padilha da Silva ◽  
Fábio Y. Moraes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Bone Metastases ◽  
Palliative Radiation ◽  
Palliative Radiation Therapy ◽  
Eortc Qlq C30 ◽  
Eortc Qlq ◽  
Painful Bone Metastases ◽  
Brazilian Cohort

scholarly journals Safety and clinical activity of intratumoral MEDI9197 alone and in combination with durvalumab and/or palliative radiation therapy in patients with advanced solid tumors

2020 ◽  
Vol 8 (2) ◽  
pp. e001095 ◽  
Author(s):  
Lillian Siu ◽  
Joshua Brody ◽  
Shilpa Gupta ◽  
Aurélien Marabelle ◽  
Antonio Jimeno ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Solid Tumors ◽  
Phase 1 ◽  
Objective Response ◽  
Clinical Activity ◽  
Advanced Solid Tumors ◽  
Palliative Radiation ◽  
Cell Counts ◽  
Palliative Radiation Therapy ◽  
Grade 3

BackgroundMEDI9197 is an intratumorally administered toll-like receptor 7 and 8 agonist. In mice, MEDI9197 modulated antitumor immune responses, inhibited tumor growth and increased survival. This first-time-in-human, phase 1 study evaluated MEDI9197 with or without the programmed cell death ligand-1 (PD-L1) inhibitor durvalumab and/or palliative radiation therapy (RT) for advanced solid tumors.Patients and methodsEligible patients had at least one cutaneous, subcutaneous, or deep-seated lesion suitable for intratumoral (IT) injection. Dose escalation used a standard 3+3 design. Patients received IT MEDI9197 0.005–0.055 mg with or without RT (part 1), or IT MEDI9197 0.005 or 0.012 mg plus durvalumab 1500 mg intravenous with or without RT (part 3), in 4-week cycles. Primary endpoints were safety and tolerability. Secondary endpoints included pharmacokinetics, pharmacodynamics, and objective response based on Response Evaluation Criteria for Solid Tumors version 1.1. Exploratory endpoints included tumor and peripheral biomarkers that correlate with biological activity or predict response.ResultsFrom November 2015 to March 2018, part 1 enrolled 35 patients and part 3 enrolled 17 patients; five in part 1 and 2 in part 3 received RT. The maximum tolerated dose of MEDI9197 monotherapy was 0.037 mg, with dose-limiting toxicity (DLT) of cytokine release syndrome in two patients (one grade 3, one grade 4) and 0.012 mg in combination with durvalumab 1500 mg with DLT of MEDI9197-related hemorrhagic shock in one patient (grade 5) following liver metastasis rupture after two cycles of MEDI9197. Across parts 1 and 3, the most frequent MEDI9197-related adverse events (AEs) of any grade were fever (56%), fatigue (31%), and nausea (21%). The most frequent MEDI9197-related grade ≥3 events were decreased lymphocytes (15%), neutrophils (10%), and white cell counts (10%). MEDI9197 increased tumoral CD8+ and PD-L1+ cells, inducing type 1 and 2 interferons and Th1 response. There were no objective clinical responses; 10 patients in part 1 and 3 patients in part 3 had stable disease ≥8 weeks.ConclusionIT MEDI9197 was feasible for subcutaneous/cutaneous lesions but AEs precluded its use in deep-seated lesions. Although no patients responded, MEDI9197 induced systemic and intratumoral immune activation, indicating potential value in combination regimens in other patient populations.Trial registration numberNCT02556463.

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