Role of Radiation Therapy in Platinum-Resistant Recurrent Ovarian Cancer Diagnosed by FDG-PET/Contrast-Enhanced CT

Author(s):  
H. Asano ◽  
R. Kinoshita ◽  
T. Kitahara ◽  
S. Nishi ◽  
H. Watari ◽  
...  
2016 ◽  
Author(s):  
S. Dash ◽  
A. Goel ◽  
S. Sogani

Purpose: To evaluate the role of 18F-FDG PET with contrast enhanced CT (PET-CECT) in early detection of recurrence in follow up patients of carcinoma cervix. Methods: Patients with histopathologically proven carcinoma cervix who underwent chemotherapy, radiotherapy and/or surgery and on follow up were recruited in the study. Fifty-two patients underwent 18F-FDG PET-CECT for detection of recurrence. The median age was 51.5 (average = 53.4) years. PET-CECT studies were evaluated and analyzed separately by an experienced nuclear medicine physician and a radiologist independently. The physicians were blinded for the patient history. PET-CECT results were validated with histopathological correlation, conventional radiologic imaging/follow up PET-CECT study and clinical follow up. Results: Out of 52 patients, 34 patients were reported as positive for recurrence, 17 of these were having active local recurrence and 31 patients had regional lymph nodal metastases, 14 patients had distant metastases (out of them 6 patients had distant lymph node metastases, 6 had pulmonary metastases, 4 had skeletal metastases and two had liver metastases). Remaining 18 patients were reported as negative for recurrence. The lung was the most common site for distant metastasis. Patient were then further evaluated based on histopathological correlation, conventional radiologic imaging and follow up PET-CECT scan and five were found to be false positive and one patient was identified as false negative. The sensitivity, specificity, positive and negative predictive value were derived to be 96.7%, 77.3%, 85.3% and 94.4%, respectively. Accuracy was calculated to be 88.5%. Conclusions: 18F-FDG PET-CECT is a very useful non-invasive modality for the early detection of recurrence and metastatic workup in patients with carcinoma cervix with a very high sensitivity and negative predictive value. It is also useful in targeting biopsy sites in suspected cases of recurrence.


2013 ◽  
Vol 131 (2) ◽  
pp. 389-394 ◽  
Author(s):  
Johanna Hynninen ◽  
Jukka Kemppainen ◽  
Maija Lavonius ◽  
Johanna Virtanen ◽  
Jaakko Matomäki ◽  
...  

Author(s):  
Raluca-Ioana Dascălu ◽  
Dan Nicolae Păduraru ◽  
Alexandra Bolocan ◽  
Daniel Ion ◽  
Octavian Andronic

Background: Gastric cancer is one of the most common and leading causes of cancer death worldwide, with an increasing risk and prevalence. Although the usage of 18-FDG PET-CT in gastric cancer evaluation remains a matter of debate and is not consistently recommended by international guidelines, our descriptive review aims to highlight its actual role in the diagnostic accuracy, staging, therapeutic management, and relapse monitoring of this malignancy. Methods: The current research was conducted using scholarly databases including PubMed, Scopus, and Google Scholar by searching useful science journals, references, and abstracts on the topic. The keywords used were “gastric cancer” AND “PET-CT”. Results: 18-FDG PET-CT remains a promising method with increasing clinical utility not only across a wide variety of malignancies, but also among gastric cancer patients. Conclusions: We are certain that with further improvements, this technique could improve the diagnosis and evaluation of gastric cancer, and make it more approachable and accurate. Keywords gastric cancer (GC), PET-CT, 18-FDG PET-CT, 18F-FDG uptake, ceCT (contrast-enhanced CT)


2008 ◽  
Vol 35 (10) ◽  
pp. 1912-1920 ◽  
Author(s):  
Kazuhiro Kitajima ◽  
Koji Murakami ◽  
Erena Yamasaki ◽  
Yasushi Kaji ◽  
Ichio Fukasawa ◽  
...  

Radiology ◽  
2010 ◽  
Vol 257 (1) ◽  
pp. 125-134 ◽  
Author(s):  
Evis Sala ◽  
Masako Kataoka ◽  
Neeta Pandit-Taskar ◽  
Nicole Ishill ◽  
Svetlana Mironov ◽  
...  

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