scholarly journals Incremental Role of 18F-FDG PET with contrast enhanced CT (PET-CECT) in detection of recurrence of carcinoma cervix

2016 ◽  
Author(s):  
S. Dash ◽  
A. Goel ◽  
S. Sogani

Purpose: To evaluate the role of 18F-FDG PET with contrast enhanced CT (PET-CECT) in early detection of recurrence in follow up patients of carcinoma cervix. Methods: Patients with histopathologically proven carcinoma cervix who underwent chemotherapy, radiotherapy and/or surgery and on follow up were recruited in the study. Fifty-two patients underwent 18F-FDG PET-CECT for detection of recurrence. The median age was 51.5 (average = 53.4) years. PET-CECT studies were evaluated and analyzed separately by an experienced nuclear medicine physician and a radiologist independently. The physicians were blinded for the patient history. PET-CECT results were validated with histopathological correlation, conventional radiologic imaging/follow up PET-CECT study and clinical follow up. Results: Out of 52 patients, 34 patients were reported as positive for recurrence, 17 of these were having active local recurrence and 31 patients had regional lymph nodal metastases, 14 patients had distant metastases (out of them 6 patients had distant lymph node metastases, 6 had pulmonary metastases, 4 had skeletal metastases and two had liver metastases). Remaining 18 patients were reported as negative for recurrence. The lung was the most common site for distant metastasis. Patient were then further evaluated based on histopathological correlation, conventional radiologic imaging and follow up PET-CECT scan and five were found to be false positive and one patient was identified as false negative. The sensitivity, specificity, positive and negative predictive value were derived to be 96.7%, 77.3%, 85.3% and 94.4%, respectively. Accuracy was calculated to be 88.5%. Conclusions: 18F-FDG PET-CECT is a very useful non-invasive modality for the early detection of recurrence and metastatic workup in patients with carcinoma cervix with a very high sensitivity and negative predictive value. It is also useful in targeting biopsy sites in suspected cases of recurrence.

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1198
Author(s):  
Jean-Baptiste Le Goubey ◽  
Charline Lasnon ◽  
Ines Nakouri ◽  
Laure Césaire ◽  
Michel de Pontville ◽  
...  

Aim: To perform a comprehensive analysis of discordances between contrast-enhanced CT (ceCT) and 18F-FDG PET/CT in the evaluation of the extra-cerebral treatment monitoring in patients with stage IV melanoma. Materials and methods: We conducted a retrospective monocentric observational study over a 3-year period in patients referred for 18F-FDG PET/CT and ceCT in the framework of therapy monitoring of immune checkpoint (ICIs) as of January 2017. Imaging reports were analyzed by two physicians in consensus. The anatomical site responsible for discordances, as well as induced changes in treatment were noted. Results: Eighty patients were included and 195 pairs of scans analyzed. Overall, discordances occurred in 65 cases (33%). Eighty percent of the discordances (52/65) were due to 18F-FDG PET/CT scans upstaging the patient. Amongst these discordances, 17/52 (33%) led to change in patient’s management, the most frequent being radiotherapy of a progressing site. ceCT represented 13/65 (20%) of discordances and induced changes in patients’ management in 2/13 cases (15%). The most frequent anatomical site involved was subcutaneous for 18F-FDG PET/CT findings and lung or liver for ceCT. Conclusions: Treatment monitoring with 18F-FDG PET/CT is more efficient than ceCT and has a greater impact in patient’s management.


2014 ◽  
Vol 35 (5) ◽  
pp. 472-477 ◽  
Author(s):  
Edwin E.G.W. ter Voert ◽  
Hanneke W.M. van Laarhoven ◽  
Peter J.M. Kok ◽  
Wim J.G. Oyen ◽  
Eric P. Visser ◽  
...  

2017 ◽  
Vol 157 (3) ◽  
pp. 439-447 ◽  
Author(s):  
Joshua K. Cho ◽  
Thomas J. Ow ◽  
Andrew Y. Lee ◽  
Richard V. Smith ◽  
Nicolas F. Schlecht ◽  
...  

Author(s):  
Guang-Yu Li ◽  
Ju-Lu Hong ◽  
Si-Yun Wang ◽  
Zhi Xie ◽  
En-Tao Liu ◽  
...  

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 3710-3710
Author(s):  
C. Carnaghi ◽  
A. Chiti ◽  
K. Marzo ◽  
M. Rodari ◽  
L. Rimassa ◽  
...  

2017 ◽  
Vol 42 (3) ◽  
pp. e149-e156 ◽  
Author(s):  
Marn Joon Park ◽  
Jungsu S. Oh ◽  
Jong-Lyel Roh ◽  
Jae Seung Kim ◽  
Jeong Hyun Lee ◽  
...  

2012 ◽  
Vol 37 (5) ◽  
pp. 453-459 ◽  
Author(s):  
Renaud Guignard ◽  
Marija Simukoniene ◽  
Valentina Garibotto ◽  
Osman Ratib

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