scholarly journals First-in-human validation of CT-based proton range prediction using prompt gamma imaging in prostate-cancer treatments

2021 ◽  
Author(s):  
Jonathan Berthold ◽  
Chirasak Khamfongkhruea ◽  
Johannes Petzoldt ◽  
Julia Thiele ◽  
Tobias Hölscher ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prompt Gamma ◽  
Cancer Treatments ◽  
Gamma Imaging ◽  
Human Validation ◽  
Prompt Gamma Imaging ◽  
Prostate Cancer Treatments

scholarly journals Causal inference in continuous time: an example on prostate cancer therapy

Biostatistics ◽  
2018 ◽  
Vol 21 (1) ◽  
pp. 172-185 ◽  
Author(s):  
Pål Christie Ryalen ◽  
Mats Julius Stensrud ◽  
Sophie Fosså ◽  
Kjetil Røysland
Keyword(s):  
Prostate Cancer ◽  
Continuous Time ◽  
Causal Effect ◽  
Structural Models ◽  
Marginal Structural Models ◽  
Cancer Treatments ◽  
Discrete Parameter ◽  
Inverse Probability Weights ◽  
Using Data ◽  
Prostate Cancer Treatments

Abstract In marginal structural models (MSMs), time is traditionally treated as a discrete parameter. In survival analysis on the other hand, we study processes that develop in continuous time. Therefore, Røysland (2011. A martingale approach to continuous-time marginal structural models. Bernoulli 17, 895–915) developed the continuous-time MSMs, along with continuous-time weights. The continuous-time weights are conceptually similar to the inverse probability weights that are used in discrete time MSMs. Here, we demonstrate that continuous-time MSMs may be used in practice. First, we briefly describe the causal model assumptions using counting process notation, and we suggest how causal effect estimates can be derived by calculating continuous-time weights. Then, we describe how additive hazard models can be used to find such effect estimates. Finally, we apply this strategy to compare medium to long-term differences between the two prostate cancer treatments radical prostatectomy and radiation therapy, using data from the Norwegian Cancer Registry. In contrast to the results of a naive analysis, we find that the marginal cumulative incidence of treatment failure is similar between the strategies, accounting for the competing risk of other death.

scholarly journals OC-0557: Implementation and validation of an analytical model for prompt gamma imaging in scanned beam proton therapy

2015 ◽  
Vol 115 ◽  
pp. S271-S272
Author(s):  
E. Sterpin ◽  
G. Janssens ◽  
J. Smeets ◽  
F. Vander Stappen ◽  
D. Prieels ◽  
...  
Keyword(s):  
Analytical Model ◽  
Proton Therapy ◽  
Prompt Gamma ◽  
Gamma Imaging ◽  
Beam Proton ◽  
Prompt Gamma Imaging

scholarly journals [P163] Dosimetric effects from high density markers for prostate cancer treatments

2018 ◽  
Vol 52 ◽  
pp. 145-146
Author(s):  
Marcus Krantz ◽  
Angela Lund ◽  
Roumiana Chakarova
Keyword(s):  
Prostate Cancer ◽  
High Density ◽  
Cancer Treatments ◽  
Prostate Cancer Treatments
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