scholarly journals For pity’s sake! Treatment-refractory type I pityriasis rubra pilaris

2019 ◽  
Vol 5 (3) ◽  
pp. 194
Author(s):  
Kimberly Huerth ◽  
Wen Chen ◽  
Pooja Khera ◽  
Mary Maiberger
Author(s):  
G. Licata ◽  
A. Gambardella ◽  
G. Calabrese ◽  
F. Pagliuca ◽  
R. Alfano ◽  
...  

2010 ◽  
Vol 14 (4) ◽  
pp. 185-188 ◽  
Author(s):  
Yao-Hua Zhang ◽  
Youwen Zhou ◽  
Nigel Ball ◽  
Ming-Wan Su ◽  
Jin-Hua Xu ◽  
...  

Background: Pityriasis rubra pilaris (PRP) has unknown etiology and is often refractory to conventional therapies. Objective: To document a PRP patient's response to adalimumab therapy and to highlight the potential role of tumor necrosis factor (TNF) in the development of PRP skin lesions. Methods: A patient received adalimumab therapy at standard dosing intervals. In addition, the messenger ribonucleic acid (mRNA) of TNF in the lesional and perilesional normal skin was quantified in two patients with PRP. Results: The patient responded to adalimumab therapy and achieved clinical remission by 4 months. There was a significant elevation of TNF mRNA in the lesional skin of PRP. Conclusion: TNF upregulation is detected in PRP lesional skin, consistent with the observed clinical efficacy of TNF blockade for the treatment of PRP.


2006 ◽  
Vol 47 (2) ◽  
pp. 124-129 ◽  
Author(s):  
Shobhan Manoharan ◽  
Stephen White ◽  
Krishna Gumparthy

2019 ◽  
Vol 131 (4) ◽  
pp. 1000-1003 ◽  
Author(s):  
Georgios A. Maragkos ◽  
Rouzbeh Motiei-Langroudi ◽  
Aristotelis S. Filippidis ◽  
Efstathios Papavassiliou

Levonorgestrel-releasing intrauterine devices (LIUDs) are thought to release this progestin locally in the uterus to limit side effects. Authors here present a case of treatment-refractory hydrocephalus and pseudomeningocele (PMC), both of which fully resolved after LIUD removal.A 35-year-old woman with an implanted LIUD developed symptomatic PMC and hydrocephalus after suboccipital craniectomy for Chiari malformation type I. Over the next 8 months, she underwent ventriculoperitoneal shunt placement and two attempts at needle decompression of the fluid collection, which did not relieve her symptoms or the PMC, except for a few days at a time. Subsequently, she had her LIUD removed. Three weeks after removal of the LIUD, her symptoms as well as the fluid collection resolved completely without any further intervention. Thus, the increased intracranial pressure and associated persistence of the PMC may be partially attributed to the LIUD.This case indicates that a persistent problem (PMC and intracranial hypertension) that may be associated with the LIUD rapidly resolves after its removal. Implication of LIUDs as the cause of intracranial hypertension is still a matter of controversy. Further studies are needed to evaluate any potential causal relationship between LIUDs and intracranial hypertension, and physicians are advised to consider this scenario in their differential diagnosis.


2014 ◽  
Vol 105 (10) ◽  
pp. 955-957
Author(s):  
C. Martín Callizo ◽  
J. Molinero Caturla ◽  
J. Sánchez Sánchez ◽  
R.M. Penín Mosquera

2019 ◽  
Vol 29 (5) ◽  
pp. 524-537
Author(s):  
Carina Engelmann ◽  
Peter Elsner ◽  
Diana Miguel

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