scholarly journals Kinetic Separation of Oxidative and Non-oxidative Metabolism in Single Phagosomes from Alveolar Macrophages: Impact on Bacterial Killing

iScience ◽  
2020 ◽  
Vol 23 (11) ◽  
pp. 101759
Author(s):  
Vladimir Riazanski ◽  
Zihao Sui ◽  
Deborah J. Nelson
Keyword(s):  
Alveolar Macrophages ◽  
Oxidative Metabolism ◽  
Bacterial Killing ◽  
Kinetic Separation

Lyso(bis)phosphatidic acid: A novel source of arachidonic acid for oxidative metabolism by rabbit alveolar macrophages

1985 ◽  
Vol 130 (2) ◽  
pp. 800-806 ◽  
Author(s):  
Felicia R. Cochran ◽  
Janice R. Connor ◽  
Vicki L. Roddick ◽  
B.Moseley Waite
Keyword(s):  
Arachidonic Acid ◽  
Phosphatidic Acid ◽  
Alveolar Macrophages ◽  
Oxidative Metabolism

β-agonists can depress oxidative metabolism of alveolar macrophages

1986 ◽  
Vol 19 (5-6) ◽  
pp. 353-354 ◽  
Author(s):  
P. A. J. Henricks ◽  
B. Esch ◽  
F. P. Nijkamp
Keyword(s):  
Alveolar Macrophages ◽  
Oxidative Metabolism

scholarly journals Alveolar macrophages in pulmonary host defence- the unrecognised role of apoptosis as a mechanism of intracellular bacterial killing

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Jody Aberdein ◽  
Joby Cole ◽  
Martin Bewley ◽  
David H. Dockrell
Keyword(s):  
Alveolar Macrophages ◽  
Host Defence ◽  
Bacterial Killing

Aggregates of ultrafine particles modulate lipid peroxidation and bacterial killing by alveolar macrophages

2007 ◽  
Vol 104 (2) ◽  
pp. 250-257 ◽  
Author(s):  
Margot Lundborg ◽  
Rabea Bouhafs ◽  
Per Gerde ◽  
Pär Ewing ◽  
Per Camner ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Alveolar Macrophages ◽  
Ultrafine Particles ◽  
Bacterial Killing

Oxidative Metabolism of Alveolar Macrophages from Young Asymptomatic Cigarette Smokers

CHEST Journal ◽  
1980 ◽  
Vol 77 (2) ◽  
pp. 270-271 ◽  
Author(s):  
J.R. Hoidal ◽  
R.B. Fox ◽  
P.A. LeMarbre ◽  
H.E. Takif ◽  
J.E. Repine
Keyword(s):  
Alveolar Macrophages ◽  
Oxidative Metabolism ◽  
Cigarette Smokers

Effects of air pollutants on the oxidative metabolism and phagocytic capacity of pulmonary alveolar macrophages

1983 ◽  
Vol 12 (2-3) ◽  
pp. 417-427 ◽  
Author(s):  
Lennart Romert ◽  
Vibeke Bernson ◽  
Bertil Pettersson
Keyword(s):  
Alveolar Macrophages ◽  
Oxidative Metabolism ◽  
Air Pollutants ◽  
Phagocytic Capacity ◽  
Pulmonary Alveolar Macrophages

scholarly journals TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice

2012 ◽  
Vol 209 (11) ◽  
pp. 1937-1952 ◽  
Author(s):  
Kathrin Steinwede ◽  
Stefanie Henken ◽  
Jennifer Bohling ◽  
Regina Maus ◽  
Bianca Ueberberg ◽  
...  
Keyword(s):  
Alveolar Macrophages ◽  
Pneumococcal Pneumonia ◽  
Caspase 3 ◽  
Bacterial Challenge ◽  
Macrophage Cell ◽  
Therapeutic Application ◽  
Bacterial Killing ◽  
Apoptotic Death ◽  
Tnf Superfamily

Apoptotic death of alveolar macrophages observed during lung infection with Streptococcus pneumoniae is thought to limit overwhelming lung inflammation in response to bacterial challenge. However, the underlying apoptotic death mechanism has not been defined. Here, we examined the role of the TNF superfamily member TNF-related apoptosis-inducing ligand (TRAIL) in S. pneumoniae–induced macrophage apoptosis, and investigated the potential benefit of TRAIL-based therapy during pneumococcal pneumonia in mice. Compared with WT mice, Trail−/− mice demonstrated significantly decreased lung bacterial clearance and survival in response to S. pneumoniae, which was accompanied by significantly reduced apoptosis and caspase 3 cleavage but rather increased necrosis in alveolar macrophages. In WT mice, neutrophils were identified as a major source of intraalveolar released TRAIL, and their depletion led to a shift from apoptosis toward necrosis as the dominant mechanism of alveolar macrophage cell death in pneumococcal pneumonia. Therapeutic application of TRAIL or agonistic anti-DR5 mAb (MD5-1) dramatically improved survival of S. pneumoniae–infected WT mice. Most importantly, neutropenic mice lacking neutrophil-derived TRAIL were protected from lethal pneumonia by MD5-1 therapy. We have identified a previously unrecognized mechanism by which neutrophil-derived TRAIL induces apoptosis of DR5-expressing macrophages, thus promoting early bacterial killing in pneumococcal pneumonia. TRAIL-based therapy in neutropenic hosts may represent a novel antibacterial treatment option.

Oxidative Metabolism of Alveolar Macrophages from Young Asymptomatic Cigarette Smokers

CHEST Journal ◽  
1980 ◽  
Vol 77 (2) ◽  
pp. 270-271 ◽  
Author(s):  
J.R. Hoidal ◽  
R.B. Fox ◽  
P.A. LeMarbre ◽  
H.E. Takiff ◽  
J.E. Repine
Keyword(s):  
Alveolar Macrophages ◽  
Oxidative Metabolism ◽  
Cigarette Smokers

The phagocytosis and bacterial killing in AIDS alveolar macrophages is not related to reduction of the lymphocyte subpopulations in the lung

1994 ◽  
Vol 75 ◽  
pp. 99
Author(s):  
G. Velluti ◽  
G.C. Garuti ◽  
F. Gilioli ◽  
F. Luppi ◽  
G. De Donno ◽  
...  
Keyword(s):  
Alveolar Macrophages ◽  
Lymphocyte Subpopulations ◽  
Bacterial Killing
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