GW29-e1746 Nicorandil attenuates carotid intimal hyperplasia after balloon catheter injury in diabetic rats

The effects of the somatostatin analogue, angiopeptin (BIM-23014), on neoendothelial function, as evidenced by formation of prostaglandin (PG) I2 and by acetylcholine-induced relaxation (formation of endothelial-derived relaxing factor), were investigated in the rabbit aorta. A balloon catheter injury of the thoracic and abdominal aorta was induced in New Zealand White rabbits. Animals treated with angiopeptin for 2 or 4 wk were compared with untreated rabbits at 2 or 4 wk after the induction of injury, as well as to sham-operated controls. When the rabbits were killed, vascular rings were assessed for arachidonic acid-stimulated PGI2 formation, acetylcholine-induced relaxation, and the degree of intimal hyperplasia. Vascular rings from animals treated with angiopeptin exhibited enhanced acetylcholine-induced relaxation; however, angiopeptin treatment had no effect on arachidonic acid-stimulated PGI2 formation. Intimal hyperplasia in treated animals was reduced by 36%. Treatment with another somatostatin analogue, BIM-23030, did not enhance relaxation or inhibit intimal hyperplasia. These data suggest that treatment with angiopeptin may inhibit intimal hyperplasia in part by its beneficial effect on neoendothelial function.

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Effect of Endothelin-1 Infusion on the Development of Intimal Hyperplasia After Balloon Catheter Injury

Journal of Cardiovascular Pharmacology ◽

10.1097/00005344-199322008-00093 ◽

1993 ◽

Vol 22 (Supplement 8) ◽

pp. S355-S359 ◽

Cited By ~ 40

Author(s):

Jeffrey D. Trachtenberg ◽

Shaping Sun ◽

Eric T. Choi ◽

Allan D. Callow ◽

Una S. Ryan

Keyword(s):

Intimal Hyperplasia ◽

Balloon Catheter ◽

Endothelin 1 ◽

Balloon Catheter Injury

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Effects of low-dose candesartan on the rate of re-endothelialisation following vascular wound healing

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/14703203010020011401 ◽

2001 ◽

Vol 2 (1_suppl) ◽

pp. S81-S83

Author(s):

Prakash Koshy ◽

Amanda Self ◽

Philip J Kadowitz ◽

Vivian A Fonseca ◽

Dennis B McNamara

Keyword(s):

Wound Healing ◽

Intimal Hyperplasia ◽

Low Dose ◽

Aortic Wall ◽

Balloon Catheter ◽

Vascular Wall ◽

Aortic Injury ◽

Wound Healing Response ◽

New Zealand White Rabbits ◽

Balloon Catheter Injury

The wound healing response of the vascular wall to injury involves re-endothelialisation of the denuded luminal surface and thickening of the intimal area (intimal hyperplasia), as expressed by the intimal-to-medial area ratio (I/M). Candesartan, at doses of 1 mg/kg/day or higher, has been reported to attenuate the intimal hyperplastic response. We tested the hypothesis that candesartan, at doses lower than those associated with attenuation of intimal hyperplasia, may affect re-endothelialisation. New Zealand White rabbits were subjected to balloon catheter injury to the thoracic aorta. Candesartan, at doses of 50, 100, and 500 µg/kg/day, was delivered via an Alzet pump placed in the abdomen one week prior to aortic injury. There was no attenuation of the hyperplastic response of the aortic wall. However, at 50 µg/kg/day the rate of reendothelialisation was significantly increased. These data suggest that candesartan may exhibit pleiotropic effects on vascular wound healing, in addition to the well-known effect of attenuating the development of intimal hyperplasia.

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