Clinical course of concurrent lymphocytic interstitial pneumonia and common variable immunodeficiency*1

2004 ◽  
Vol 113 (2) ◽  
pp. S122
Author(s):  
E SCANNELL
Keyword(s):  
Interstitial Pneumonia ◽  
Common Variable Immunodeficiency ◽  
Clinical Course ◽  
Lymphocytic Interstitial Pneumonia ◽  
Common Variable

Lymphocytic infiltrations of the lung

2010 ◽  
pp. 3431-3434
Author(s):  
D.J. Hendrick
Keyword(s):  
Interstitial Pneumonia ◽  
Common Variable Immunodeficiency ◽  
Case History ◽  
Lymphocytic Infiltration ◽  
Focus Of Attention ◽  
Productive Cough ◽  
Lymphocytic Interstitial Pneumonia ◽  
History Of ◽  
Common Variable

Case History—A 37 yr old woman with common variable immunodeficiency, now presenting with a 6-week history of breathlessness and productive cough. Many disorders are associated with lymphocytic infiltration of the lung, but there is a spectrum of conditions in which such infiltration is the chief focus of attention, ranging from benign (e.g. lymphocytic interstitial pneumonia) to malignant (e.g. lymphoma)....

scholarly journals Clinical immunology Thrombocytopenia in common variable immunodeficiency patients – clinical course, management, and effect of immunoglobulins

2015 ◽  
Vol 1 ◽  
pp. 83-90 ◽  
Author(s):  
Anna Pituch-Noworolska ◽  
Maciej Siedlar ◽  
Danuta Kowalczyk ◽  
Anna Szaflarska ◽  
Anita Błaut-Szlósarczyk ◽  
...  
Keyword(s):  
Common Variable Immunodeficiency ◽  
Clinical Immunology ◽  
Clinical Course ◽  
Course Management ◽  
Common Variable

Acute Cerebellitis and Myeloradiculitis Associated With SARS-CoV-2 Infection in Common Variable Immunodeficiency—A Case Report

2021 ◽  
pp. 194187442110502
Author(s):  
Hernan Nicolas Lemus ◽  
Miryam Alkayyali ◽  
Eonjung Kim ◽  
Charlotte Cunnigham-Rundles ◽  
Dewitt Pyburn ◽  
...  
Keyword(s):  
Immune System ◽  
Common Variable Immunodeficiency ◽  
Clinical Course ◽  
Adaptive Immune System ◽  
Complex Interaction ◽  
Cns Injury ◽  
Adaptive Immune ◽  
The Brain ◽  
Common Variable

The role of the adaptive immune system in mediating COVID-19 is largely unknown. Therefore, it is difficult to predict the clinical course in patients with common variable immunodeficiency (CVID), a disease characterized by dysfunctional lymphocytes and impaired antibody production. We report a case of SARS-CoV-2 infection presenting as isolated neurological symptoms in a patient with CVID. The patient subsequently improved following steroids, intravenous immunoglobulin, and convalescent plasma (CP). The latter has been shown to be safe and efficacious in treating COVID-19 in patients with primary immunodeficiency. Recent data suggest that the mechanism of CNS injury in COVID-19 may be due to immunological dysregulation rather than direct viral-mediated injury. This case exemplifies the complex interaction between the brain, the immune system, and the SARS-CoV-2 virus.

scholarly journals Common Variable Immunodeficiency (CVID) with Granulomatous Interstitial Lung Disease (GLILD) and SARS COVID-19 Infection: Case Report and Review of Literature

2021 ◽  
Author(s):  
Debendra Pattanaik ◽  
Shaunah Ritter ◽  
Joseph Fahhoum
Keyword(s):  
Case Report ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Common Variable Immunodeficiency ◽  
Clinical Course ◽  
Pneumococcal Vaccination ◽  
Severe Infection ◽  
Ivig Therapy ◽  
Ivig Treatment ◽  
Common Variable

Abstract Background We present a case of CVID complicated by granulomatous interstitial lung disease (GLILD). This patient clinical course was further complicated by COVID-19 infection. This is only the 2nd known case report of COVID 19 in CVID with GLILD. The clinical course and outcome of COVID 19 infection with common variable immunodeficiency (CVID) and GLILD is not well known. Case presentation: Our patient met the clinical features of CVID secondary to low IgG/IgA, recurrent infections, and failure to respond to pneumococcal vaccination. He was treated with monthly maintenance IVIG therapy. Our patient also was diagnosed with co-existing GLILD that despite IVIG treatment was progressing. The patient needed to be started on Rituxan and Mycophenolate Mofetil to achieve control but unfortunately became infected with COVID19 delaying his treatment for GLILD. Our patient only suffered from mild COVID 19 infection and was able to make antibodies to this. We believe severe infection was avoided as his CVID was well controlled with IVIG therapy despite progression of his granulomatous interstitial lung disease. Conclusion In conclusion, our patient with CVID with co-existing biopsy proven granulomatous interstitial lung disease despite being very high risk for severe COVID 19 infection only had mild infection. This was believed to be due to well controlled CVID with IVIG therapy.

scholarly journals Common variable immunodeficiency (CVID) with granulomatous interstitial lung disease (GLILD) and SARS COVID-19 infection: case report and review of literature

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Debendra Pattanaik ◽  
Shaunah Ritter ◽  
Joseph Fahhoum
Keyword(s):  
Case Report ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Common Variable Immunodeficiency ◽  
Clinical Course ◽  
Pneumococcal Vaccination ◽  
Severe Infection ◽  
Ivig Therapy ◽  
Ivig Treatment ◽  
Common Variable

Abstract Background We present a case of CVID complicated by granulomatous interstitial lung disease (GLILD). This patient clinical course was further complicated by COVID-19 infection. This is only the 2nd known case report of COVID 19 in CVID with GLILD. The clinical course and outcome of COVID 19 infection with common variable immunodeficiency (CVID) and GLILD is not well known. Case presentation Our patient met the clinical features of CVID secondary to low IgG/IgA, recurrent infections, and failure to respond to pneumococcal vaccination. He was treated with monthly maintenance IVIG therapy. Our patient also was diagnosed with co-existing GLILD that despite IVIG treatment was progressing. The patient needed to be started on Rituxan and Mycophenolate mofetil to achieve control but unfortunately became infected with COVID19 delaying his treatment for GLILD. Our patient only suffered from mild COVID 19 infection and was able to make antibodies to this. We believe severe infection was avoided as his CVID was well controlled with IVIG therapy despite progression of his granulomatous interstitial lung disease. Conclusion In conclusion, our patient with CVID with co-existing biopsy proven granulomatous interstitial lung disease despite being very high risk for severe COVID 19 infections only had mild infection. This was believed to be due to well controlled CVID with IVIG therapy.

Common Variable Immunodeficiency (CVID) – variables humorales Immundefektsyndrom

Praxis ◽  
2007 ◽  
Vol 96 (1) ◽  
pp. 3-11
Author(s):  
Suter-Meyer ◽  
Nigg ◽  
Kolyvanos Naumann ◽  
Käser ◽  
Vetter
Keyword(s):  
Common Variable Immunodeficiency ◽  
Common Variable
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