House-dust endotoxin exposure and recurrent wheezing in infants: a cohort study

2005 ◽  
Vol 115 (4) ◽  
pp. 894 ◽  
Author(s):  
V.E.V. Rullo ◽  
D. Solé ◽  
V. Valente ◽  
C. Nakamura ◽  
F.J. Nobrega ◽  
...  
2009 ◽  
Vol 123 (2) ◽  
pp. S210-S210
Author(s):  
V.E.V. Rullo ◽  
L.K. Arruda ◽  
V. Valente ◽  
A.S. Zampolo ◽  
M.R. Cardoso ◽  
...  

2006 ◽  
Vol 48 (5) ◽  
pp. 462-469 ◽  
Author(s):  
Monika Nitschke ◽  
Louis S. Pilotto ◽  
Robyn G. Attewell ◽  
Brian J. Smith ◽  
Dino Pisaniello ◽  
...  

2018 ◽  
Vol 48 (8) ◽  
pp. 1063-1067 ◽  
Author(s):  
K. Hasegawa ◽  
P. A. Piedra ◽  
C. S. Bauer ◽  
J. C. Celedón ◽  
J. M. Mansbach ◽  
...  

2006 ◽  
Vol 117 (2) ◽  
pp. S178-S179
Author(s):  
V.E. Rullo ◽  
D. Solé ◽  
L. Arruda ◽  
V. Valente ◽  
C. Nakamura ◽  
...  

Author(s):  
Jing Guo ◽  
Wenjing Zhu ◽  
Huimin Wang ◽  
Patrick G. Holt ◽  
Guicheng Zhang ◽  
...  

Author(s):  
Valentina Agnese Ferraro ◽  
Eugenio Baraldi ◽  
Matteo Stocchero ◽  
Sara Bozzetto ◽  
Michela Maretti ◽  
...  

2017 ◽  
Vol 75 (2) ◽  
pp. 139-147 ◽  
Author(s):  
Grethe Elholm ◽  
Vivi Schlünssen ◽  
Gert Doekes ◽  
Ioannis Basinas ◽  
Anneli Clea Skjelmose Bolund ◽  
...  

ObjectivesLittle is known about risk factors for new onset and loss of atopic sensitisation in adulthood. The aim is to examine the longitudinal effect of quantitatively assessed endotoxin exposures on changes in specific allergen sensitisation in young adults.MethodsThe cohort consisted of 1113 young Danish farmers and rural controls, with a mean age of 19 years at baseline. Sensitisation to birch pollen, grass pollen, cat dander and house dust mite was measured by specific IgE levels in serum samples from baseline and at 15 years’ follow-up. Changes in sensitisation were analysed in relation to cumulative endotoxin exposure during follow-up, considering early life farm exposure.ResultsEndotoxin exposure during follow-up was significantly associated with less new onset of specifically grass and birch pollen sensitisation. For the highest versus lowest quartile of cumulative endotoxin exposure, the OR for new-onset IgE sensitisation was 0.35 (0.13–0.91) for birch and 0.14 (0.05–0.50) for grass. On the other hand, loss of pollen sensitisation showed a positive, although mostly non-significant, association with increased levels of endotoxin exposure. Endotoxin exposure was not associated with significant changes in cat dander and house dust mite sensitisation.ConclusionsHigh exposure to endotoxin during young adulthood appears to protect against new onset of pollen sensitisation, independent of childhood farm exposure.


2017 ◽  
Author(s):  
Hanchen Chen ◽  
George Astrakianakis ◽  
Paul Demers ◽  
Hugh Davies

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