birch pollen
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Allergy ◽  
2022 ◽  
Author(s):  
Aurora Cabrera ◽  
Alexander C.Y. Foo ◽  
Michael C. Fitzgerald ◽  
Geoffrey A. Mueller
Keyword(s):  

Aerobiologia ◽  
2021 ◽  
Author(s):  
Katarzyna Dąbrowska-Zapart ◽  
Tadeusz Niedźwiedź

AbstractThe study's main objective was to specify the extent to which weather conditions were related to the course of birch pollen seasons in the years 1997–2020. The impact of atmospheric conditions on the daily concentrations of birch pollen grains, the Annual pollen integral (APIn), and the length of pollen seasons were studied. The dependency between each meteorological condition and various features of the birch pollen season was determined using Spearman’s rho correlation, the Kruskal–Wallis test, and cluster analysis with the k-means method. It has been shown that the duration of sunshine and average air temperature occurring within 14 days preceding the season has the most significant influence on the beginning of a birch pollen season. The value of daily birch pollen concentrations in Sosnowiec showed a statistically significant positive correlation with the duration of sunlight and the average and maximum wind speed. The daily concentration also depended on the synoptic situation: the mass airflow direction, the type of air mass inflow, and the type of weather front. The near-ground temperature influenced the APIn of birch pollen grains during the period of 14 days before the beginning of the season and the meteorological conditions occurring in the summer of the preceding year such as the maximum temperature, duration of sunlight, the maximum and average wind speed, and the relative air humidity. It was concluded that the length of birch pollen seasons decreased year by year.


Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7573
Author(s):  
Tuya Narangerel ◽  
Radosław Bonikowski ◽  
Konrad Jastrząbek ◽  
Alina Kunicka-Styczyńska ◽  
Aleksandra Plucińska ◽  
...  

Oxytropis pseudoglandulosa is used in Mongolian traditional medicine due to its numerous reported health-promoting effects. To date, there are very few scientific reports that describe this species. In this article, its volatile oil composition, lipid extract composition, total phenolic and flavonoid content, antibacterial and allergenic properties are elucidated for the first time. Hexadecanoic acid, fokienol and tricosane were determined as the most notable components of the volatile oil, at 13.13, 11.46 and 5.55%, respectively. Methyl benzoate was shown to be the most abundant component of lipid extract at 40.69, followed by (E)-prop-2-enoic acid, 3-phenyl- and benzenepropanoic acid, at 18.55 and 9.97%. With a TPC of 6.620 mg GAE g−1 and TFC of 10.316 mg QE g−1, the plant extract of O. pseudoglandulosa indicated good antioxidant activity measured by IC50 at 18.761 µg mL−1. Of the 12 tested microorganisms, B. subtilis and S. cerevisiae were the shown to be most susceptible to the plant extract, with MIC at 2.081 and 0.260% (v/v), respectively. Bet v 1—a major birch pollen allergen found in plant-based foods—was determined to be at 192.02 ng g−1 with ELISA. Such a wide spectrum of biological activity indicated by O. pseudoglandulosa lends credence for its application in food industry. Its exerted antioxidant and antimicrobial effects could improve preservation of low-processed food dedicated for consumers afflicted with allergies. Hexadecanoic acid supplemented in foods with dietary plant extracts could add to the potential anti-inflammatory impact. The analysis of lipid makeup suggests O. pseudoglandulosa extract could also be considered as natural pesticide in organic farming.


Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3415
Author(s):  
Yen-Ju Lin ◽  
Adam Flaczyk ◽  
Sonja Wolfheimer ◽  
Alexandra Goretzki ◽  
Annette Jamin ◽  
...  

Developing new adjuvants/vaccines and better understanding their mode-of-action is an important task. To specifically improve birch pollen allergy treatment, we designed a fusion protein consisting of major birch pollen allergen Betv1 conjugated to the TLR5-ligand flagellin (rFlaA:Betv1). This study investigates the immune-modulatory effects of rFlaA:Betv1 on airway epithelial cells. LA-4 mouse lung epithelial cells were stimulated with rFlaA:Betv1 in the presence/absence of various inhibitors with cytokine- and chemokine secretion quantified by ELISA and activation of intracellular signaling cascades demonstrated by Western blot (WB). Either LA-4 cells or LA-4-derived supernatants were co-cultured with BALB/c bone marrow-derived myeloid dendritic cells (mDCs). Compared to equimolar amounts of flagellin and Betv1 provided as a mixture, rFlaA:Betv1 induced higher secretion of IL-6 and the chemokines CCL2 and CCL20 from LA-4 cells and a pronounced MAPK- and NFκB-activation. Mechanistically, rFlaA:Betv1 was taken up more strongly and the induced cytokine production was inhibited by NFκB-inhibitors, while ERK- and p38-MAPK-inhibitors only suppressed IL-6 and CCL2 secretion. In co-cultures of LA-4 cells with mDCs, rFlaA:Betv1-stimulated LA-4 cells p38-MAPK- and COX2-dependently secreted PGE2, which modulated DC responses by suppressing pro-inflammatory IL-12 and TNF-α secretion. Taken together, these results contribute to our understanding of the mechanisms underlying the strong immune-modulatory effects of flagellin-containing fusion proteins.


2021 ◽  
Vol 48 ◽  
pp. 102005
Author(s):  
Tabea Pöhler ◽  
Ute Körner ◽  
Peter Wilhelm Gündling

2021 ◽  
pp. 105944
Author(s):  
Marie Choël ◽  
Anastasia Ivanovsky ◽  
Antoine Roose ◽  
Mona Hamzé ◽  
Anne-Marie Blanchenet ◽  
...  

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3361
Author(s):  
Waka Ishida ◽  
Tatsuma Kishimoto ◽  
Fumio Takaiwa ◽  
Ken Fukuda

We investigated the prophylactic and therapeutic effects of the oral administration of transgenic rice seeds expressing a hypoallergenic Bet v 1 derivative of allergic birch pollen conjunctivitis in mice. Transgenic rice seed depositing a chimeric molecule called TPC7 (tree pollen chimera 7) created by DNA shuffling of Bet v 1 family sequences from birch, alder and hazel in protein bodies of endosperm was generated. BALB/c mice were sensitized to birch pollen in alum and challenged with pollen in eyedrops. They were fed TPC7 transgenic or non-transgenic (control) rice seeds for 14 d before sensitization (prophylactic protocol) or 17 d after sensitization (therapeutic protocol). The clinical score and number of conjunctival eosinophils were significantly lower in TPC7-fed mice than in the control mice based on both the prophylactic and therapeutic protocols. Serum concentration of allergen-specific IgE did not differ between TPC7-fed and control groups in either protocol. Prophylactic administration of TPC7 downregulated the production of IL-4 and IFN-γ, whereas therapeutic administration of TPC7 upregulated the production of IFN-γ by allergen-stimulated splenocytes. Prophylactic or therapeutic oral administration of transgenic rice expressing TPC7 suppressed birch pollen-induced allergic conjunctivitis in mice. Feeding transgenic rice is a potentially effective approach as an allergen-specific immunotherapy for allergic conjunctivitis.


2021 ◽  
Vol 27 (4) ◽  
pp. 4128-4132
Author(s):  
Georgi Nikolov ◽  
◽  
Rusana Tsvetanova ◽  
Mariela Hristova-Savova ◽  
◽  
...  

Purpose: Platanus pollen is a serious cause of asthma, allergic rhinitis and conjunctivitis in many European countries. The aim of the present pilot study is to investigate the sensitization to 3 different plane tree species in a group of patients with pollinosis. Materials and methods: 21 patients were surveyed - 11 men and 10 women. A skin prick test was performed with a set of allergens: Grass pollen mix; Betulaceae pollen mix; Platanusorientalis; Platanusacerifolia; Platanusoccidentalis. Results: 95% of patients are sensitized to grass pollen, with moderate positive skin reactions predominating. 86% have a co-sensitization to tree pollens also, particularly to the birch tree family. Only 3 (14%) of the studied patients showed slight positive skin tests to the studied plane tree allergens, with no significant difference in sensitization to studied Platanus species (p>0,05). Conclusion: At present, the sensitization to different Platanus species is not comparable to that of grass or birch pollen. However, it will be necessary to conduct new long-term, large-scale studies to prove whether Platanus pose a real threat to people in urban areas. The results of this interdisciplinary study are important both for clinical allergologists and for landscape architects and ecologists involved in the planning and management of urban green infrastructure.


Author(s):  
Timo Hugg ◽  
Qianlai Luo ◽  
Taina Lajunen ◽  
Maritta Jaakkola ◽  
Jouni Jaakkola
Keyword(s):  

This is a Letter and does not include an abstract.


2021 ◽  
Vol 12 ◽  
Author(s):  
Oluwatoyin Akinfenwa ◽  
Huey-Jy Huang ◽  
Birgit Linhart ◽  
Margarete Focke-Tejkl ◽  
Susanne Vrtala ◽  
...  

IgE-mediated allergy to birch pollen affects more than 100 million patients world-wide. Bet v 1, a 17 kDa protein is the major allergen in birch pollen responsible for allergic rhinoconjunctivitis and asthma in birch pollen allergic patients. Allergen-specific immunotherapy (AIT) based on therapeutic administration of Bet v 1-containing vaccines is an effective treatment for birch pollen allergy but no allergen-specific forms of prevention are available. We developed a mouse model for IgE sensitization to Bet v 1 based on subcutaneous injection of aluminum-hydroxide adsorbed recombinant Bet v 1 and performed a detailed characterization of the specificities of the IgE, IgG and CD4+ T cell responses in sensitized mice using seven synthetic peptides of 31-42 amino acids length which comprised the Bet v 1 sequence and the epitopes recognized by human CD4+ T cells. We then d.emonstrate that preventive systemic administration of a mix of synthetic non-allergenic Bet v 1 peptides to 3-4 week old mice significantly reduced allergic immune responses, including IgE, IgG, IgE-mediated basophil activation, CD4+ T cell and IL-4 responses to the complete Bet v 1 allergen but not to the unrelated major grass pollen allergen Phl p 5, without inducing Bet v 1-specific allergic sensitization or adaptive immunity. Our results thus demonstrate that early preventive administration of non-allergenic synthetic T cell epitope-containing allergen peptides could be a safe strategy for the prevention of allergen-specific IgE sensitization.


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