scholarly journals Peanut oral immunotherapy transiently expands circulating Ara h 2–specific B cells with a homologous repertoire in unrelated subjects

2015 ◽  
Vol 136 (1) ◽  
pp. 125-134.e12 ◽  
Author(s):  
Sarita U. Patil ◽  
Adebola O. Ogunniyi ◽  
Agustin Calatroni ◽  
Vasisht R. Tadigotla ◽  
Bert Ruiter ◽  
...  
Keyword(s):  
B Cells ◽  
Oral Immunotherapy ◽  
Ara H 2

scholarly journals Increase in IgG4 following Peanut Oral Immunotherapy is primarily limited to a single specific epitope against Ara h 2

2020 ◽  
Vol 145 (2) ◽  
pp. AB339
Author(s):  
Paul Turner ◽  
Nandinee Patel ◽  
Dianne Campbell ◽  
Robert Getts ◽  
Paul Kearney ◽  
...  
Keyword(s):  
Oral Immunotherapy ◽  
Ara H 2 ◽  
Specific Epitope

scholarly journals Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens

2017 ◽  
Vol 139 (4) ◽  
pp. 1393-1396.e6 ◽  
Author(s):  
Riikka Uotila ◽  
Anna Kaarina Kukkonen ◽  
Dario Greco ◽  
Anna Susanna Pelkonen ◽  
Mika Juhani Mäkelä
Keyword(s):  
Oral Immunotherapy ◽  
Ara H 2 ◽  
Ara H 6

Induction of Antigen-Specific B Cells During Peanut Oral Immunotherapy Using Novel Tetramer-Based Approach

2013 ◽  
Vol 131 (2) ◽  
pp. AB86
Author(s):  
Sarita U. Patil ◽  
Stephanie Kubala ◽  
Alisa K. Brennan ◽  
Alex Ma ◽  
James Moon ◽  
...  
Keyword(s):  
B Cells ◽  
Oral Immunotherapy

scholarly journals Mechanisms of allergen-specific B cell tolerance in children with cow’s milk-oral immunotherapy and natural outgrowth of milk allergy

2021 ◽  
Author(s):  
Pattraporn Satitsuksanoa ◽  
Willem van de Veen ◽  
Ge Tan ◽  
Oliver Wirz ◽  
Kirstin Jansen ◽  
...  
Keyword(s):  
B Cells ◽  
Immune Tolerance ◽  
Oral Immunotherapy ◽  
Essential Elements ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Allergen Specific Immunotherapy ◽  
Cow's Milk ◽  
Clinical Healing ◽  
Natural Tolerance

Abstract Antigen-specific memory B cells play a key role in the induction of immune tolerance to food allergens and clinical healing. Here, we characterized the role of allergen-specific B cells in immune tolerance induced by oral allergen-specific immunotherapy (OIT) and natural tolerance that developed in children who spontaneously outgrew cow’s milk allergy. Increased frequency of circulating milk allergen αS1-casein -specific B cells was observed after OIT and natural tolerance (NT). Milk desensitized subjects showed partial acquisition of tolerance phenotypic features induced tolerance, suggesting that desensitization is an earlier stage of tolerance. Immunoregulatory genes such as IL10RA and IGHG4 are significantly upregulated after OIT (desensitized and tolerance) versus NT. Secreted proteins from allergen-specific B cells revealed higher amounts of regulatory cytokines, IL-10 and TGF-β after OIT and NT. Taken together, allergen-specific B cells are essential elements in regulating food allergen tolerance in both OIT-received and naturally-resolved individuals.

scholarly journals Ara h 2 Specific IgA B Cell Repertoire Matures During Peanut Oral Immunotherapy

2020 ◽  
Vol 145 (2) ◽  
pp. AB181
Author(s):  
Nicole LaHood ◽  
Sarita Patil ◽  
Wayne Shreffler ◽  
Yamini Virkud ◽  
Bert Ruiter ◽  
...  
Keyword(s):  
B Cell ◽  
Oral Immunotherapy ◽  
Cell Repertoire ◽  
Ara H 2 ◽  
B Cell Repertoire

scholarly journals Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy

2020 ◽  
Vol 5 (45) ◽  
pp. eaay4209 ◽  
Author(s):  
Ramona A. Hoh ◽  
Shilpa A. Joshi ◽  
Ji-Yeun Lee ◽  
Brock A. Martin ◽  
Sushama Varma ◽  
...  
Keyword(s):  
Food Allergy ◽  
B Cells ◽  
Peanut Allergy ◽  
Plasma Cells ◽  
Cell Phenotype ◽  
Ara H 2 ◽  
Dietary Antigens ◽  
High Throughput Dna Sequencing ◽  
B Lineage ◽  
Genetic Rearrangements

B cells in human food allergy have been studied predominantly in the blood. Little is known about IgE+ B cells or plasma cells in tissues exposed to dietary antigens. We characterized IgE+ clones in blood, stomach, duodenum, and esophagus of 19 peanut-allergic patients, using high-throughput DNA sequencing. IgE+ cells in allergic patients are enriched in stomach and duodenum, and have a plasma cell phenotype. Clonally related IgE+ and non-IgE–expressing cell frequencies in tissues suggest local isotype switching, including transitions between IgA and IgE isotypes. Highly similar antibody sequences specific for peanut allergen Ara h 2 are shared between patients, indicating that common immunoglobulin genetic rearrangements may contribute to pathogenesis. These data define the gastrointestinal tract as a reservoir of IgE+ B lineage cells in food allergy.

scholarly journals Exploiting CD22 on antigen-specific B cells to prevent allergy to the major peanut allergen Ara h 2

2017 ◽  
Vol 139 (1) ◽  
pp. 366-369.e2 ◽  
Author(s):  
Kelly A. Orgel ◽  
Shiteng Duan ◽  
Benjamin L. Wright ◽  
Soheila J. Maleki ◽  
John C. Wolf ◽  
...  
Keyword(s):  
B Cells ◽  
Peanut Allergen ◽  
Ara H 2

Peanut Component Analysis Predicts Response to Ara h 2-Dominant Oral Immunotherapy

2015 ◽  
Vol 135 (2) ◽  
pp. AB24
Author(s):  
Alice E.W. Hoyt ◽  
Alexander J. Schuyler ◽  
Julia A. Cronin ◽  
Eva-Maria King ◽  
Martin D. Chapman ◽  
...  
Keyword(s):  
Component Analysis ◽  
Oral Immunotherapy ◽  
Ara H 2

scholarly journals Decrease in early basophil sensitivity to Ara h 2 correlates with sustained unresponsiveness in peanut oral immunotherapy

2018 ◽  
Vol 141 (2) ◽  
pp. AB287
Author(s):  
Colby P. Rondeau ◽  
Agustin Calatroni ◽  
Neal Smith ◽  
Huong Tang ◽  
Yamini V. Virkud ◽  
...  
Keyword(s):  
Oral Immunotherapy ◽  
Ara H 2 ◽  
Sustained Unresponsiveness
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