P4-023: Cerebral blood flow, white matter lesions and cognitive performance. The Somatotrophics, Memory and Aging Research Trial (SMART)-MR Study

2008 ◽  
Vol 4 ◽  
pp. T674-T674
Author(s):  
Mirjam I. Geerlings ◽  
Auke P.A. Appelman ◽  
Koen L. Vincken ◽  
Willem P. Th M. Mali ◽  
Yolanda van der Graaf
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Cognitive Performance ◽  
White Matter Lesions ◽  
Aging Research ◽  
Mr Study

scholarly journals IC-P1-025: Cerebral blood flow, white matter lesions and cognitive performance: The SMART-MR study

2008 ◽  
Vol 4 ◽  
pp. T18-T19
Author(s):  
Mirjam I. Geerlings ◽  
Auke P.A. Appelman ◽  
Koen L. Vincken ◽  
Willem P. Th M. Mali ◽  
Yolanda van der Graaf
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Cognitive Performance ◽  
White Matter Lesions ◽  
Mr Study

scholarly journals Total Cerebral Blood Flow, White Matter Lesions and Brain Atrophy: The SMART-MR Study

2007 ◽  
Vol 28 (3) ◽  
pp. 633-639 ◽  
Author(s):  
Auke PA Appelman ◽  
Yolanda van der Graaf ◽  
Koen L Vincken ◽  
Audrey M Tiehuis ◽  
Theo D Witkamp ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Magnetic Resonance ◽  
Brain Atrophy ◽  
Brain Volume ◽  
White Matter Lesions ◽  
Arterial Disease ◽  
Subcortical Brain ◽  
Mr Study

We investigated whether total cerebral blood flow (CBF) was associated with brain atrophy, and whether this relation was modified by white matter lesions (WML). Within the Second Manifestations of ARTerial disease-magnetic resonance (SMART-MR) study, a prospective cohort study among patients with arterial disease, cross-sectional analyses were performed in 828 patients (mean age 58±10 years, 81% male) with quantitative flow, atrophy, and WML measurements on magnetic resonance imaging (MRI). Total CBF was measured with MR angiography and was expressed per 100 mL brain volume. Total brain volume and ventricular volume were divided by intracranial volume to obtain brain parenchymal fraction (BPF) and ventricular fraction (VF). Lower BPF indicates more global brain atrophy, whereas higher VF indicates more subcortical brain atrophy. Mean CBF was 52.0±10.2 mL/min per 100 mL, mean BPF was 79.2±2.9%, and mean VF was 2.03±0.96%. Linear regression analyses showed that lower CBF was associated with more subcortical brain atrophy, after adjusting for age, sex, vascular risk factors, intima-media thickness, and lacunar infarcts, but only in patients with moderate to severe WML (upper quartile of WML): Change in VF per s.d. decrease in CBF 0.18%, 95% CI: 0.02 to 0.34%. Our findings suggest that cerebral hypoperfusion in the presence of WML may be associated with subcortical brain atrophy.

P3-155: Cerebral blood flow, white matter lesions and risk of hippocampal atrophy: The SMART-MR study

2009 ◽  
Vol 5 (4S_Part_13) ◽  
pp. P389-P389
Author(s):  
Mirjam I. Geerlings ◽  
Arnoud J.G. Knoops ◽  
Auke P.A. Appelman ◽  
Theo D. Witkamp ◽  
Yolanda Van Der Graaf ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
White Matter Lesions ◽  
Hippocampal Atrophy ◽  
Mr Study

scholarly journals Multiple Factors Involved in the Pathogenesis of White Matter Lesions

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Jing Lin ◽  
Dilong Wang ◽  
Linfang Lan ◽  
Yuhua Fan
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Genetic Factors ◽  
Subsequent Development ◽  
White Matter Lesions ◽  
Blood Brain Barrier Disruption ◽  
Fluid Attenuated Inversion Recovery ◽  
Cerebral Blood Flow Autoregulation ◽  
Brain Barrier Disruption

White matter lesions (WMLs), also known as leukoaraiosis (LA) or white matter hyperintensities (WMHs), are characterized mainly by hyperintensities on T2-weighted or fluid-attenuated inversion recovery (FLAIR) images. With the aging of the population and the development of imaging technology, the morbidity and diagnostic rates of WMLs are increasing annually. WMLs are not a benign process. They clinically manifest as cognitive decline and the subsequent development of dementia. Although WMLs are important, their pathogenesis is still unclear. This review elaborates on the advances in the understanding of the pathogenesis of WMLs, focusing on anatomy, cerebral blood flow autoregulation, venous collagenosis, blood brain barrier disruption, and genetic factors. In particular, the attribution of WMLs to chronic ischemia secondary to venous collagenosis and cerebral blood flow autoregulation disruption seems reasonable. With the development of gene technology, the effect of genetic factors on the pathogenesis of WMLs is gaining gradual attention.

High total cerebral blood flow is associated with a decrease of white matter lesions

2004 ◽  
Vol 251 (12) ◽  
pp. 1481-1485 ◽  
Author(s):  
R. H. C. Bisschops ◽  
Y. Graaf ◽  
W. P. Th. M. Mali ◽  
J. Grond
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
White Matter Lesions

Effects of global atrophy, white matter lesions, and cerebral blood flow on age-related changes in speed, memory, intelligence, vocabulary, and frontal function.

2007 ◽  
Vol 21 (6) ◽  
pp. 684-695 ◽  
Author(s):  
Patrick Rabbitt ◽  
Oemetse Mogapi ◽  
Marietta Scott ◽  
Neil Thacker ◽  
Christine Lowe ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
White Matter Lesions ◽  
Age Related ◽  
Age Related Changes

scholarly journals Venous cerebral blood flow quantification and cognition in patients with sickle cell anemia

2022 ◽  
pp. 0271678X2110723
Author(s):  
Hanne Stotesbury ◽  
Patrick W Hales ◽  
Melanie Koelbel ◽  
Anna M Hood ◽  
Jamie M Kawadler ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Cognitive Performance ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Flow Quantification ◽  
Arterial Oxygen ◽  
High Signal ◽  
Sagittal Sinus

Prior studies have described high venous signal qualitatively using arterial spin labelling (ASL) in patients with sickle cell anemia (SCA), consistent with arteriovenous shunting. We aimed to quantify the effect and explored cross-sectional associations with arterial oxygen content (CaO2), disease-modifying treatments, silent cerebral infarction (SCI), and cognitive performance. 94 patients with SCA and 42 controls underwent cognitive assessment and MRI with single- and multi- inflow time (TI) ASL sequences. Cerebral blood flow (CBF) and bolus arrival time (BAT) were examined across gray and white matter and high-signal regions of the sagittal sinus. Across gray and white matter, increases in CBF and reductions in BAT were observed in association with reduced CaO2 in patients, irrespective of sequence. Across high-signal sagittal sinus regions, CBF was also increased in association with reduced CaO2 using both sequences. However, BAT was increased rather than reduced in patients across these regions, with no association with CaO2. Using the multiTI sequence in patients, increases in CBF across white matter and high-signal sagittal sinus regions were associated with poorer cognitive performance. These novel findings highlight the utility of multiTI ASL in illuminating, and identifying objectively quantifiable and functionally significant markers of, regional hemodynamic stress in patients with SCA.

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