The effect of hepatocyte growth factor (HGF) on gene transcription during intestinal adaptation

2010 ◽  
Vol 211 (3) ◽  
pp. S70
Author(s):  
Michael S. Katz ◽  
Keith A. Thatch ◽  
Marshall Z. Schwartz
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Gene Transcription ◽  
Intestinal Adaptation ◽  
Hepatocyte Growth

Hepatocyte growth factor increases glucagon immunoreactivity in jejunal cells during intestinal adaptation

2006 ◽  
Vol 41 (1) ◽  
pp. 150-154 ◽  
Author(s):  
Shaheen J. Timmapuri ◽  
David M. Otterburn ◽  
Hwyda Arafat ◽  
Marshall Z. Schwartz
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Intestinal Adaptation ◽  
Glucagon Immunoreactivity ◽  
Hepatocyte Growth

scholarly journals Hepatocyte growth factor regulates cyclooxygenase-2 expression via β-catenin, Akt, and p42/p44 MAPK in human bronchial epithelial cells

2008 ◽  
Vol 294 (4) ◽  
pp. L778-L786 ◽  
Author(s):  
Young H. Lee ◽  
Yuichiro J. Suzuki ◽  
Autumn J. Griffin ◽  
Regina M. Day
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Hepatocyte Growth Factor ◽  
Gene Transcription ◽  
Bronchial Epithelial Cells ◽  
Cyclooxygenase 2 ◽  
Human Bronchial Epithelial Cells ◽  
Bronchial Epithelial ◽  
Cox 2 ◽  
Hepatocyte Growth

Hepatocyte growth factor (HGF) is upregulated in response to lung injury and has been implicated in tissue repair through its antiapoptotic and proliferative activities. Cyclooxygenase-2 (COX-2) is an inducible enzyme in the biosynthetic pathway of prostaglandins, and its activation has been shown to play a role in cell growth. Here, we report that HGF induces gene transcription of COX-2 in human bronchial epithelial cells (HBEpC). Treatment of HBEpC with HGF resulted in phosphorylation of the HGF receptor (c-Met), activation of Akt, and upregulation of COX-2 mRNA. Adenovirus-mediated gene transfer of a dominant negative (DN) Akt mutant revealed that HGF increased COX-2 mRNA in an Akt-dependent manner. COX-2 promoter analysis in luciferase reporter constructs showed that HGF regulation required the β-catenin-responsive T cell factor-4 binding element (TBE). The HGF activation of the COX-2 gene transcription was blocked by DN mutant of β-catenin or by inhibitors that blocked activation of Akt. Inhibition of p42/p44 MAPK pathway blocked HGF-mediated activation of β-catenin gene transcription but not Akt activation, suggesting that p42/p44 MAPK acts in a parallel mechanism for β-catenin activation. We also found that inhibition of COX-2 with NS-398 blocked HGF-induced growth in HBEpC. Together, the results show that the HGF increases COX-2 gene expression via an Akt-, MAPK-, and β-catenin-dependent pathway in HBEpC.

Enhancement of intestinal adaptation by hepatocyte growth factor

1998 ◽  
Vol 33 (2) ◽  
pp. 235-239 ◽  
Author(s):  
Yoshifumi Kato ◽  
Dahong Yu ◽  
Marshall Z Schwartz
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Intestinal Adaptation ◽  
Hepatocyte Growth

Role of Bcl-xL in hepatocyte growth factor-elicited epithelial protection in idiopathic pulmonary fibrosis

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
S Skwarna ◽  
I Henneke ◽  
W Seeger ◽  
T Geiser ◽  
A Günther ◽  
...  
Keyword(s):  
Growth Factor ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Hepatocyte Growth Factor ◽  
Hepatocyte Growth
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