NKX3.1 is a Sensitive Marker for Detecting Metastatic Prostatic Carcinoma Except for Small Cell Variant on Fine-Needle Aspiration Smears

2018 ◽  
Vol 7 (5) ◽  
pp. S39-S40
Author(s):  
Qiong Gan ◽  
Cicily Joseph ◽  
Ming Guo ◽  
Xiaoping Sun ◽  
Yun Gong
2011 ◽  
Vol 40 (7) ◽  
pp. 619-623 ◽  
Author(s):  
Darya Buehler ◽  
Michelle Waknitz ◽  
William Rehrauer ◽  
Erik Ranheim ◽  
Suzanne Selvaggi

2000 ◽  
Vol 23 (2) ◽  
pp. 118-123 ◽  
Author(s):  
Jan F. Silverman ◽  
Rodney J. Landreneau ◽  
Charles D. Sturgis ◽  
Stephen S. Raab ◽  
Karl R. Fox ◽  
...  

2019 ◽  
Vol 152 (4) ◽  
pp. 495-501 ◽  
Author(s):  
Qiong Gan ◽  
Cicily T Joseph ◽  
Ming Guo ◽  
Miao Zhang ◽  
Xiaoping Sun ◽  
...  

Abstract Objectives NK3 homeobox 1 (NKX3.1) has been increasingly used to diagnose metastatic prostatic carcinoma in histologic samples. However, its utility and reliability in cytologic direct smears have not been studied. Methods A total of 59 fine-needle aspiration (FNA) cases with a definitive diagnosis of metastatic carcinoma from the prostate were included. The cases were grouped based on different Gleason score in their corresponding primary tumors and morphologic variants. For each case, tumor cells were immunostained with NKX3.1, prostate-specific antigen (PSA), and prostatic acid phosphatase (PAP) on cell-transferred smears. Results NKX3.1 was strongly and diffusely positive in all 40 metastatic prostatic adenocarcinomas, including those with ductal features, but negative for the 19 small cell carcinoma (SmCC) cases. NKX3.1 had a better detection rate than PSA (13/50, 26%) and PAP (0/47, 0%). Conclusions NKX3.1 immunostaining on FNA smears is highly reliable for detecting metastatic prostatic carcinomas of conventional and ductal types but not for SmCC.


2004 ◽  
Vol 48 (2) ◽  
pp. 254-258 ◽  
Author(s):  
Sung-Eun Kim ◽  
Se Hoon Kim ◽  
Beom Jin Lim ◽  
Soon-Won Hong ◽  
Woo-Ick Yang

2011 ◽  
Vol 6 (9) ◽  
pp. 1510-1515 ◽  
Author(s):  
Martin B. von Bartheld ◽  
Michel I.M. Versteegh ◽  
Jerry Braun ◽  
Luuk N.A. Willems ◽  
Klaus F. Rabe ◽  
...  

2014 ◽  
Vol 21 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Cynthia L. Harris ◽  
Eric M. Toloza ◽  
Jason B. Klapman ◽  
Shivakumar Vignesh ◽  
Kathryn Rodriguez ◽  
...  

Urology ◽  
1988 ◽  
Vol 31 (3) ◽  
pp. 255-259 ◽  
Author(s):  
Stephen W. Dejter ◽  
Nicholas L. Constantinople ◽  
John F. Bresette ◽  
Ian J. Spence ◽  
Cheryl M. Reichert

Sign in / Sign up

Export Citation Format

Share Document