Use of nonsteroidal anti-inflammatory drugs in early axial spondyloarthritis in daily practice: Data from the DESIR cohort

2017 ◽  
Vol 84 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Anna Molto ◽  
Benjamin Granger ◽  
Daniel Wendling ◽  
Maxime Dougados ◽  
Laure Gossec
Keyword(s):  
Axial Spondyloarthritis ◽  
Daily Practice ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Non-steroidal anti-inflammatory drug effects on renal and cardiovascular function: from physiology to clinical practice

2019 ◽  
Vol 27 (8) ◽  
pp. 850-867 ◽  
Author(s):  
Aderville Cabassi ◽  
Stefano Tedeschi ◽  
Stefano Perlini ◽  
Ignazio Verzicco ◽  
Riccardo Volpi ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Drug Effects ◽  
Daily Practice ◽  
The Elderly ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Inappropriate Use ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Cyclooxygenase 2 Inhibitors

Excessive or inappropriate use of non-steroidal anti-inflammatory drugs can affect cardiovascular and renal function. Non-steroidal anti-inflammatory drugs, both non-selective and selective cyclooxygenase 2 inhibitors, are among the most widely used drugs, especially in the elderly, with multiple comorbidities. Exposition to a polypharmacy burden represents a favourable substrate for the onset of non-steroidal anti-inflammatory drug-induced deleterious effects. Cardiovascular and renal issues concerning the occurrence of myocardial infarction, atrial fibrillation, heart failure and arterial hypertension, as well as acute or chronic kidney damage, become critical for clinicians in their daily practice. We discuss current available knowledge regarding prostanoid physiology in vascular, cardiac and renal systems, pointing out potential negative non-steroidal anti-inflammatory drug-related issues in clinical practice.

scholarly journals Brazilian recommendations for the use of nonsteroidal anti-inflammatory drugs in patients with axial spondyloarthritis

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
Ricardo da Cruz Lage ◽  
Claudia Diniz Lopes Marques ◽  
Thauana Luiza Oliveira ◽  
Gustavo Gomes Resende ◽  
Charles Lubianca Kohem ◽  
...  
Keyword(s):  
Randomized Clinical Trials ◽  
Axial Spondyloarthritis ◽  
Meta Analysis ◽  
Evaluation Methodology ◽  
Assessment Development ◽  
Brazilian Society ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

AbstractSpondyloarthritis (SpA) is a group of chronic inflammatory systemic diseases characterized by axial and/or peripheral joints inflammation, as well as extra-articular manifestations. Over some decades, nonsteroidal anti-inflammatory drugs (NSAIDs) have been the basis for the pharmacological treatment of patients with axial spondyloarthritis (axSpA). However, the emergence of the immunobiologic agents brought up the discussion about the role of NSAIDs in the management of these patients. The objective of this guideline is to provide recommendations for the use of NSAIDs for the treatment of axSpA. A panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis of randomized clinical trials for 15 predefined questions. The Grading of Recommendations, Assessment, Development and Evaluation methodology to assess the quality of evidence and formulate recommendations were used, and at least 70% agreement of the voting panel was needed. Fourteen recommendations for the use of NSAIDs in the treatment of patients with axSpA were elaborated. The purpose of these recommendations is to support clinicians’ decision making, without taking out his/her autonomy when prescribing for an individual patient.

scholarly journals Effect of non-steroidal anti-inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: results from the German Spondyloarthritis Inception Cohort

2012 ◽  
Vol 71 (10) ◽  
pp. 1616-1622 ◽  
Author(s):  
Denis Poddubnyy ◽  
Martin Rudwaleit ◽  
Hildrun Haibel ◽  
Joachim Listing ◽  
Elisabeth Märker-Hermann ◽  
...  
Keyword(s):  
Axial Spondyloarthritis ◽  
Inception Cohort ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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