Development and validation of a cystic fibrosis genetic knowledge questionnaire within the general population of the United States

Abstract Background Although the 6-item Kessler psychological scale (K6) is a useful depression screening scale in clinical settings and epidemiological surveys, little is known about the distribution model of the K6 score in the general population. Using four major national survey datasets from the United States and Japan, we explored the mathematical pattern of the K6 distributions in the general population. Methods We analyzed four datasets from the National Health Interview Survey, the National Survey on Drug Use and Health, and the Behavioral Risk Factor Surveillance System in the United States, and the Comprehensive Survey of Living Conditions in Japan. We compared the goodness of fit between three models: exponential, power law, and quadratic function models. Graphical and regression analyses were employed to investigate the mathematical patterns of the K6 distributions. Results The exponential function had the best fit among the three models. The K6 distributions exhibited an exponential pattern, except for the lower end of the distribution across the four surveys. The rate parameter of the K6 distributions was similar across all surveys. Conclusions Our results suggest that, regardless of different sample populations and methodologies, the K6 scores exhibit a common mathematical distribution in the general population. Our findings will contribute to the development of the distribution model for such a depression screening scale.

Download Full-text

Measurement of Perceived Interpersonal and Societal Anti-Muslim Discrimination in the United States

Assessment ◽

10.1177/1073191120973388 ◽

2020 ◽

pp. 107319112097338

Author(s):

Naheed Ahmed

Keyword(s):

United States ◽

Online Survey ◽

Qualitative Data ◽

High Reliability ◽

The United States ◽

Discrimination Index ◽

Muslim Americans ◽

Study Results ◽

Development And Validation ◽

Component Models

Background: Hate crimes against Muslim Americans have increased exponentially in the past 20 years, but there is currently no scale for measuring perceived anti-Muslim discrimination in the United States. To fill this gap, this study used a mixed-method approach to develop scales for measuring perceived anti-Muslim discrimination. Method: Qualitative data informed the development and validation of the 19-item Societal Anti-Muslim Discrimination Index and the 9-item Interpersonal Anti-Muslim Discrimination Index. Quantitative data ( N = 347) were collected from Muslim Americans using an online survey and used to assess the anti-Muslim indexes. Results: Qualitative data contributed to the refinement scale items. Quantitative results indicated one-component models and modest to high reliability of the Interpersonal Anti-Muslim Discrimination Index (.77) and Societal Anti-Muslim Discrimination Index (.88) scales. Discussion: Study results established the validity of these novel scales for measuring the distinct facets of anti-Muslim discrimination not captured by the Everyday Discrimination Index. These scales will facilitate research on anti-Muslim discrimination and the health implications of this form of religious-based discrimination.

Download Full-text

Development and validation of the Acculturative Stress Scale for Chinese College Students in the United States (ASSCS).

Psychological Assessment ◽

10.1037/pas0000198 ◽

2016 ◽

Vol 28 (4) ◽

pp. 443-447 ◽

Cited By ~ 7

Author(s):

Jieru Bai

Keyword(s):

United States ◽

College Students ◽

Acculturative Stress ◽

The United States ◽

Chinese College Students ◽

Stress Scale ◽

Development And Validation

Download Full-text

Hepatitis C Virus Genotypes and Viral Concentrations in Participants of a General Population Survey in the United States

Gastroenterology ◽

10.1053/j.gastro.2006.06.007 ◽

2006 ◽

Vol 131 (2) ◽

pp. 478-484 ◽

Cited By ~ 112

Author(s):

Omana V. Nainan ◽

Miriam J. Alter ◽

Deanna Kruszon-Moran ◽

Feng-Xiang Gao ◽

Guoliang Xia ◽

...

Keyword(s):

United States ◽

Hepatitis C Virus ◽

Hepatitis C ◽

General Population ◽

Population Survey ◽

The United States ◽

General Population Survey ◽

Virus Genotypes ◽

Hepatitis C Virus Genotypes

Download Full-text

Surveillance of Colorectal Cancer (CRC) in Cystic Fibrosis (CF) Patients

Gastrointestinal Disorders ◽

10.3390/gidisord3020009 ◽

2021 ◽

Vol 3 (2) ◽

pp. 84-95

Author(s):

Fabio Ingravalle ◽

Giovanni Casella ◽

Adriana Ingravalle ◽

Claudio Monti ◽

Federica De Salvatore ◽

...

Keyword(s):

Colorectal Cancer ◽

Cystic Fibrosis ◽

General Population ◽

Genetic Disorder ◽

The United States ◽

Screening Colonoscopy ◽

Transmembrane Conductance Regulator ◽

Transmembrane Conductance ◽

Increased Risk ◽

Speciality Training

Cystic Fibrosis (CF) is the commonest inherited genetic disorder in Caucasians due to a mutation in the gene CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), and it should be considered as an Inherited Colorectal Cancer (CRC) Syndrome. In the United States, physicians of CF Foundation established the “Developing Innovative Gastroenterology Speciality Training Program” to increase the research on CF in gastrointestinal and hepatobiliary diseases. The risk to develop a CRC is 5–10 times higher in CF patients than in the general population and even greater in CF patients receiving immunosuppressive therapy due to organ transplantation (30-fold increased risk relative to the general population). Colonoscopy should be considered the best screening for CRC in CF patients. The screening colonoscopy should be started at the age of 40 in CF patients and, if negative, a new colonoscopy should be performed every 5 years and every 3 years if adenomas are detected. For transplanted CF patients, the screening colonoscopy could be started at the age of 35, in transplanted patients at the age of 30 and, if before, at the age of 30. CF transplanted patients, between the age of 35 and 55, must repeat colonoscopy every 3 years. Our review draws attention towards the clinically relevant development of CRC in CF patients, and it may pave the way for further screenings and studies.

Download Full-text