Accelerated blood clearance and hypersensitivity by PEGylated liposomes containing TLR agonists

2021 ◽  
Author(s):  
Camilla Stavnsbjerg ◽  
Esben Christensen ◽  
Rasmus D. Münter ◽  
Jonas R. Henriksen ◽  
Matthias Fach ◽  
...  
Keyword(s):  
Blood Clearance ◽  
Pegylated Liposomes ◽  
Tlr Agonists ◽  
Accelerated Blood Clearance

scholarly journals Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG

2019 ◽  
Vol 311-312 ◽  
pp. 138-146 ◽  
Author(s):  
Morgan D. McSweeney ◽  
Lauren S.L. Price ◽  
Timothy Wessler ◽  
Elizabeth C. Ciociola ◽  
Leah B. Herity ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Blood Clearance ◽  
Pegylated Liposomes ◽  
Accelerated Blood Clearance

scholarly journals Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo

2019 ◽  
Vol 47 (4) ◽  
pp. 364-376 ◽  
Author(s):  
Fengling Wang ◽  
Yifan Wu ◽  
Jiwen Zhang ◽  
Huihui Wang ◽  
Xiaoting Xie ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Blood Clearance ◽  
Pegylated Liposomes ◽  
Accelerated Blood Clearance

Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs

2012 ◽  
Vol 436 (1-2) ◽  
pp. 636-643 ◽  
Author(s):  
Takuya Suzuki ◽  
Masako Ichihara ◽  
Kenji Hyodo ◽  
Eiichi Yamamoto ◽  
Tatsuhiro Ishida ◽  
...  
Keyword(s):  
Repeated Administration ◽  
Blood Clearance ◽  
Pegylated Liposomes ◽  
Accelerated Blood Clearance

scholarly journals Accelerated Blood Clearance (ABC) Phenomenon Favors the Accumulation of Tartar Emetic in Pegylated Liposomes in BALB/c Mice Liver

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Tamara C. M. Lopes ◽  
Débora F. Silva ◽  
Walyson C. Costa ◽  
Frédéric Frézard ◽  
José M. Barichello ◽  
...  
Keyword(s):  
Repeated Administration ◽  
Spleen Weight ◽  
Blood Clearance ◽  
Site Specific ◽  
Pegylated Liposomes ◽  
Specific Targeting ◽  
Mice Liver ◽  
Accelerated Blood Clearance ◽  
Abc Phenomenon ◽  
Tartar Emetic

Tartar emetic (TE) was the first drug used to treat leishmaniasis. However, its use was discontinued due to high toxicity. Association of TE with liposomes is a strategy to reduce its side effects. Pegylated liposomes (Lpeg) present lower rates of uptake by macrophages and prolonged circulation compared to their nonpegylated counterparts. However, repeated administration of Lpeg can cause an Accelerated Blood Clearance (ABC) phenomenon, whereby recognition of liposomes by antibodies results in faster phagocytosis. This work evaluated the effect of TE administration on histopathological aspects and the effect of the ABC phenomenon on targeting and toxicity in mice. Our results show that treatment with free or liposomal TE had no effect on the erythrocyte count, on liver and spleen weight, and on hepatic, splenic, and cardiac histology in mice. Severe lesions were observed on the kidneys of animals treated with a single dose of free TE. Treatment with TE in Lpeg after induction of ABC phenomenon caused a significant increase in Sb level in the liver without toxicity. Furthermore, mice treated with TE in liposomes showed normal renal histopathology. These results suggest site-specific targeting of Sb to the liver after induction of ABC phenomenon with no toxicity to other organs.

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