Identification and characterization of dipeptidyl peptidase IV inhibitory peptides from wheat gluten proteins

2021 ◽  
pp. 103396
Author(s):  
Long Ding ◽  
Ruidi Ma ◽  
Haixi You ◽  
Juanrui Li ◽  
Qingyang Ge ◽  
...  
Keyword(s):  
Wheat Gluten ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Gluten Proteins ◽  
Inhibitory Peptides ◽  
Identification And Characterization

scholarly journals Generation of wheat gluten hydrolysates with dipeptidyl peptidase IV (DPP-IV) inhibitory properties

2017 ◽  
Vol 8 (6) ◽  
pp. 2249-2257 ◽  
Author(s):  
A. B. Nongonierma ◽  
M. Hennemann ◽  
S. Paolella ◽  
R. J. FitzGerald
Keyword(s):  
Wheat Gluten ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Inhibitory Peptides ◽  
Dpp Iv

Wheat gluten hydrolysates contain known/potential DPP-IV inhibitory peptides.

scholarly journals Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice

2015 ◽  
Vol 465 (3) ◽  
pp. 433-436 ◽  
Author(s):  
Miyuki Kozuka ◽  
Takuya Yamane ◽  
Yoshihisa Nakano ◽  
Takenori Nakagaki ◽  
Iwao Ohkubo ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Identification And Characterization

Generation and characterization of dipeptidyl peptidase-IV inhibitory peptides from trypsin-hydrolyzed α-lactalbumin-rich whey proteins

2020 ◽  
Vol 318 ◽  
pp. 126333 ◽  
Author(s):  
Cheng-li Jia ◽  
Naveed Hussain ◽  
Obaroakpo Joy Ujiroghene ◽  
Xiao-yang Pang ◽  
Shu-wen Zhang ◽  
...  
Keyword(s):  
Whey Proteins ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Inhibitory Peptides

scholarly journals Characterization of Novel Dipeptidyl Peptidase-IV Inhibitory Peptides from Soft-Shelled Turtle Yolk Hydrolysate Using Orthogonal Bioassay-Guided Fractionations Coupled with In Vitro and In Silico Study

2020 ◽  
Vol 13 (10) ◽  
pp. 308
Author(s):  
Nhung Thi Phuong Nong ◽  
Yu-Kuo Chen ◽  
Wen-Ling Shih ◽  
Jue-Liang Hsu
Keyword(s):  
Dipeptidyl Peptidase ◽  
Reversed Phase ◽  
Dipeptidyl Peptidase Iv ◽  
Inhibitory Peptides ◽  
Dpp Iv ◽  
Ic50 Value ◽  
In Silico Study ◽  
Liquid Chromatography Tandem Mass

Five novel peptides (LPLF, WLQL, LPSW, VPGLAL, and LVGLPL) bearing dipeptidyl peptidase IV (DPP-IV) inhibitory activities were identified from the gastrointestinal enzymatic hydrolysate of soft-shelled turtle yolk (SSTY) proteins. Peptides were isolated separately using reversed-phase (RP) chromatography in parallel with off-line strong cation exchange (SCX) chromatography followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis to determine sequences. Among these peptides, LPSW showed the highest DPP-IV inhibitory activity with an IC50 value of 269.7 ± 15.91 µM. The results of the pre-incubation experiment and the kinetic study of these peptides indicated that WLQL is a true inhibitor and its inhibition toward DPP-IV is of an uncompetitive model, while LPLF, LPSW, and VPGLAL are real-substrates and competitive inhibitors against DPP-IV. The DPP-IV inhibitory peptides derived from SSTY hydrolysate in study are promising in the management of hyperglycemia in Type 2 diabetes.

scholarly journals Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV

2017 ◽  
Vol 175 ◽  
pp. 29-35 ◽  
Author(s):  
Ming-jin Xie ◽  
Ming-rong Zhu ◽  
Chun-Mei Lu ◽  
Yi Jin ◽  
Li-Hui Gao ◽  
...  
Keyword(s):  
Enzyme Inhibitors ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Synthesis And Characterization
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