Development of a tetraphenylporphyrin cobalt (II) modified glassy carbon electrode to monitor oxygen consumption in biological samples

2016 ◽  
Vol 775 ◽  
pp. 72-76 ◽  
Author(s):  
L.P.H. Saravia ◽  
S. Anandhakumar ◽  
A.L.A. Parussulo ◽  
T.A. Matias ◽  
C.C. Caldeira da Silva ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Biological Samples ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode

Sensitive Detection of Levocetirizine as a new Generation Antihistamine by Stripping Square Wave Voltammetry

2020 ◽  
Vol 16 (4) ◽  
pp. 424-437
Author(s):  
Kubra Ozturk ◽  
Nurgul K. Bakirhan ◽  
Sibel A. Ozkan ◽  
Bengi Uslu
Keyword(s):  
Electrochemical Sensor ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Differential Pulse ◽  
Real Sample ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Square Wave ◽  
Real Sample Analysis ◽  
Tablet Dosage

Background:: new and selective electrochemical sensor was developed for the determination of levocetirizine dihydrochloride, which is an antihistaminic drug. Method:: The investigation was performed by using cyclic, differential pulse and square wave voltammetric methods on the β-cyclodextrin modified glassy carbon electrode. It is thereby planned to obtain information about levocetirizine determination and its mechanism. Result:: The efficiency of experimental parameters including pH, scan rate, and accumulation potential and time on the anodic response of levocetirizine dihydrochloride was studied. By employing the developed method and under optimized conditions, the current showed linear dependence with a concentration in the range between 2 × 10-8 M and 6 × 10-6 M in pH 2.0 Britton Robinson (BR) buffer. Conclusion:: The achieved limits of detection and quantification were found as 3.73 × 10-10 M and 1.24 × 10-9 M, respectively. In addition, the possibility of applying the developed sensor for real sample analysis was investigated, so β-cyclodextrin modified glassy carbon electrode was used to determine levocetirizine dihydrochloride in Xyzal® tablet dosage form. Finally, this sensor was successfully applied to the real sample as a selective, simple, reproducible, repeatable electrochemical sensor.

Sign in / Sign up

Export Citation Format

Share Document