Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis

2012 ◽  
Vol 56 (3) ◽  
pp. 632-639 ◽  
Author(s):  
Julia Monsénégo ◽  
Abdelhak Mansouri ◽  
Marie Akkaoui ◽  
Véronique Lenoir ◽  
Catherine Esnous ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Insulin Sensitivity ◽  
Hepatic Steatosis ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Obese Mice ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Oxidation Capacity ◽  
Mitochondrial Fatty Acid

scholarly journals Peroxisomal oxidation of erucic acid suppresses mitochondrial fatty acid oxidation by stimulating malonyl-CoA formation in the rat liver

2020 ◽  
Vol 295 (30) ◽  
pp. 10168-10179 ◽  
Author(s):  
Xiaocui Chen ◽  
Lin Shang ◽  
Senwen Deng ◽  
Ping Li ◽  
Kai Chen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Erucic Acid ◽  
Hepatic Steatosis ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Acetyl Coa ◽  
Mitochondrial Fatty Acid Oxidation ◽  
High Erucic Acid ◽  
Malonyl Coa ◽  
Mitochondrial Fatty Acid

Feeding of rapeseed (canola) oil with a high erucic acid concentration is known to cause hepatic steatosis in animals. Mitochondrial fatty acid oxidation plays a central role in liver lipid homeostasis, so it is possible that hepatic metabolism of erucic acid might decrease mitochondrial fatty acid oxidation. However, the precise mechanistic relationship between erucic acid levels and mitochondrial fatty acid oxidation is unclear. Using male Sprague–Dawley rats, along with biochemical and molecular biology approaches, we report here that peroxisomal β-oxidation of erucic acid stimulates malonyl-CoA formation in the liver and thereby suppresses mitochondrial fatty acid oxidation. Excessive hepatic uptake and peroxisomal β-oxidation of erucic acid resulted in appreciable peroxisomal release of free acetate, which was then used in the synthesis of cytosolic acetyl-CoA. Peroxisomal metabolism of erucic acid also remarkably increased the cytosolic NADH/NAD+ ratio, suppressed sirtuin 1 (SIRT1) activity, and thereby activated acetyl-CoA carboxylase, which stimulated malonyl-CoA biosynthesis from acetyl-CoA. Chronic feeding of a diet including high-erucic-acid rapeseed oil diminished mitochondrial fatty acid oxidation and caused hepatic steatosis and insulin resistance in the rats. Of note, administration of a specific peroxisomal β-oxidation inhibitor attenuated these effects. Our findings establish a cross-talk between peroxisomal and mitochondrial fatty acid oxidation. They suggest that peroxisomal oxidation of long-chain fatty acids suppresses mitochondrial fatty acid oxidation by stimulating malonyl-CoA formation, which might play a role in fatty acid–induced hepatic steatosis and related metabolic disorders.

Sa1706 A Mitochondrial Fatty Acid Oxidation Defect Causes Hepatic Steatosis and Susceptibility for Hepatocellular Carcinoma: A Proteomics Approach

2015 ◽  
Vol 148 (4) ◽  
pp. S-1016
Author(s):  
Tripti Khare ◽  
Brian Mooney ◽  
Suzanne E. Ridenhour ◽  
Roy Lowery ◽  
Sharad Khare ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Hepatic Steatosis ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Fatty Acid Oxidation Defect ◽  
Mitochondrial Fatty Acid ◽  
Proteomics Approach

Glucocorticoids promote mitochondrial fatty acid oxidation in the fetal heart

2019 ◽  
Author(s):  
Helena Urquijo ◽  
Emma N Panting ◽  
Roderick N Carter ◽  
Emma J Agnew ◽  
Caitlin S Wyrwoll ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Fetal Heart ◽  
Acid Oxidation ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Mitochondrial Fatty Acid

scholarly journals Quantitation of acyl-CoA and acylcarnitine esters accumulated during abnormal mitochondrial fatty acid oxidation.

1991 ◽  
Vol 266 (34) ◽  
pp. 22932-22938
Author(s):  
R.S. Kler ◽  
S. Jackson ◽  
K. Bartlett ◽  
L.A. Bindoff ◽  
S. Eaton ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Mitochondrial Fatty Acid

scholarly journals Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats

2021 ◽  
Vol 1866 (4) ◽  
pp. 158887
Author(s):  
Mona Synnøve Bjune ◽  
Carine Lindquist ◽  
Marit Hallvardsdotter Stafsnes ◽  
Bodil Bjørndal ◽  
Per Bruheim ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Wistar Rats ◽  
Methylmalonic Acid ◽  
Acid Oxidation ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Mitochondrial Fatty Acid ◽  
Male Wistar Rats

scholarly journals Molecular basis of mitochondrial fatty acid oxidation defects.

1992 ◽  
Vol 33 (8) ◽  
pp. 1099-1110 ◽  
Author(s):  
PM Coates ◽  
K Tanaka
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Molecular Basis ◽  
Acid Oxidation ◽  
Mitochondrial Fatty Acid Oxidation ◽  
Mitochondrial Fatty Acid
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