scholarly journals EAPB0503: an imiquimod analog with potent in vitro activity against cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica

2020 ◽  
Vol 13 (12) ◽  
pp. 2112
Author(s):  
Rana El Hajj ◽  
Hanady Bou Youness ◽  
Laurence Lachaud ◽  
Patrick Bastien ◽  
Carine Masquefa ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Major ◽  
Vitro Activity ◽  
Leishmania Tropica ◽  
In Vitro Activity

scholarly journals EAPB0503: An Imiquimod analog with potent in vitro activity against cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica

2018 ◽  
Vol 12 (11) ◽  
pp. e0006854 ◽  
Author(s):  
Rana El Hajj ◽  
Hanady Bou Youness ◽  
Laurence Lachaud ◽  
Patrick Bastien ◽  
Carine Masquefa ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Major ◽  
Vitro Activity ◽  
Leishmania Tropica ◽  
In Vitro Activity

Inhibition by Dications of In Vitro Growth of Leishmania major and Leishmania tropica: Causative Agents of Old World Cutaneous Leishmaniasis

2008 ◽  
Vol 94 (3) ◽  
pp. 743-749 ◽  
Author(s):  
Alexa C. Rosypal ◽  
Karl A. Werbovetz ◽  
Manar Salem ◽  
Chad E. Stephens ◽  
Arvind Kumar ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Major ◽  
Leishmania Tropica ◽  
In Vitro Growth ◽  
Old World ◽  
Causative Agents

Inhibition by Dications of In Vitro Growth of Leishmania major and Leishmania tropica: Causative Agents of Old World Cutaneous Leishmaniasis

2008 ◽  
Vol 94 (3) ◽  
pp. 743 ◽  
Author(s):  
Alexa C. Rosypal ◽  
Karl A. Werbovetz ◽  
Manar Salem ◽  
Chad E. Stephens ◽  
Arvind Kumar ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Major ◽  
Leishmania Tropica ◽  
In Vitro Growth ◽  
Old World ◽  
Causative Agents

In vitro activity and in vivo efficacy of fexinidazole against New World Leishmania species

2019 ◽  
Vol 74 (8) ◽  
pp. 2318-2325 ◽  
Author(s):  
Eliane de Morais-Teixeira ◽  
Ana Rabello ◽  
Marta Marques Gontijo Aguiar
Keyword(s):  
Cutaneous Leishmaniasis ◽  
New World ◽  
Leishmania Species ◽  
Vitro Activity ◽  
In Vitro Assays ◽  
In Vitro Activity ◽  
In Vivo Evaluation ◽  
In Vivo Efficacy

Abstract Objectives To evaluate the in vitro activity and in vivo efficacy of fexinidazole against the main species that cause visceral and cutaneous New World leishmaniasis. Methods The inhibitory concentrations of fexinidazole against Leishmania (Leishmania) infantum chagasi, Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis in amastigotes were determined by in vitro activity assays. For the in vivo evaluation, animals were infected with L. (L.) infantum chagasi, L. (L.) amazonensis, L. (V.) braziliensis or Leishmania (Viannia) guyanensis and divided into groups: (i) control; and (ii) treated with oral fexinidazole, from 50 to 300 mg/kg/day. For cutaneous leishmaniasis, the size of the lesion was determined weekly after the beginning of the treatment. Upon completion, parasites were recovered from the spleen and liver, or skin lesion and spleen, and evaluated by a limiting dilution assay. Results All Leishmania isolates were susceptible to fexinidazole in the in vitro assays. The viable parasites in the liver and spleen were reduced with 100 and 300 mg/kg/day, respectively, for L. (L.) infantum chagasi. For the species causing cutaneous leishmaniasis, the viable parasites in lesions and the size of the lesions were reduced, starting from 200 mg/kg/day. The viable parasites in the spleen were also reduced with 200 and 300 mg/kg/day for L. (V.) braziliensis and L. (L.) amazonensis. Conclusions Considering the defined parameters, fexinidazole showed in vitro and in vivo activity against all tested species. This drug may represent an alternative treatment for the New World species.

scholarly journals In Vitro Activity of Cordia myxa Mucilage Extract Against Leishmania major and L. infantum Promastigotes

2015 ◽  
Vol 8 (3) ◽  
Author(s):  
Jasem Saki ◽  
Shahram Khademvatan ◽  
Nader Pazyar ◽  
Alborz Eskandari ◽  
Ali Tamoradi ◽  
...  
Keyword(s):  
Leishmania Major ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Cordia Myxa

In vitro activity of green tea extract against Leishmania major promastigotes

2012 ◽  
Vol 50 (03) ◽  
pp. 233-236 ◽  
Author(s):  
Amir Feily ◽  
Jasem Saki ◽  
Sharif Maraghi ◽  
Zahra Moosavi ◽  
Sharam Khademvatan ◽  
...  
Keyword(s):  
Green Tea ◽  
Leishmania Major ◽  
Green Tea Extract ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Tea Extract

In vitro activity of Hyssopus officinalis, Tussilage farfara, Carum copticum extracts against Leishmania major in Iran

2014 ◽  
Vol 6 ◽  
pp. 193-201 ◽  
Author(s):  
Fatemeh Tabatabaie ◽  
Mohsen Golestani ◽  
Lame Akhlaghi ◽  
Amir Hooman Asadi ◽  
Mehri Noori ◽  
...  
Keyword(s):  
Leishmania Major ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Carum Copticum ◽  
Hyssopus Officinalis
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