scholarly journals Searching for New Chemotherapies for Tropical Diseases: Ruthenium–Clotrimazole Complexes Display High in Vitro Activity against Leishmania major and Trypanosoma cruzi and Low Toxicity toward Normal Mammalian Cells

2012 ◽  
Vol 55 (8) ◽  
pp. 3867-3877 ◽  
Author(s):  
Alberto Martínez ◽  
Teresia Carreon ◽  
Eva Iniguez ◽  
Atilio Anzellotti ◽  
Antonio Sánchez ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Mammalian Cells ◽  
Leishmania Major ◽  
Vitro Activity ◽  
Tropical Diseases ◽  
In Vitro Activity ◽  
Low Toxicity

Searching for new drugs for Chagas diseases: triazole analogs display high in vitro activity against Trypanosoma cruzi and low toxicity toward mammalian cells

2018 ◽  
Vol 50 (2) ◽  
pp. 81-91 ◽  
Author(s):  
Robson Xavier Faria ◽  
Daniel Tadeu Gomes Gonzaga ◽  
Paulo Anastácio Furtado Pacheco ◽  
André Luis Almeida Souza ◽  
Vitor Francisco Ferreira ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Mammalian Cells ◽  
New Drugs ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Low Toxicity

Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives

2020 ◽  
Vol 16 (4) ◽  
pp. 487-494
Author(s):  
Natália N. Santiago ◽  
Giulianna P. de Alcântara ◽  
Juliana S. da Costa ◽  
Samir A. Carvalho ◽  
Juliana M.C. Barbosa ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Mammalian Cells ◽  
In Vitro Activity ◽  
Potential Toxicity ◽  
Standard Drug ◽  
New Family ◽  
The World ◽  
Low Toxicity

Background: Approximately, 5-7 million people are infected with T. cruzi in the world, and approximately 10,000 people per year die of complications linked to this disease. Method: This work describes the construction of a new family of hidrazonoyl substituted derivatives, structurally designed exploring the molecular hybridization between megazol and nitrofurazone. Results and Discussion: The compounds were evaluated for their in vitro activity against bloodstream trypomastigotes of Trypanosoma cruzi, etiological agent of Chagas disease, and for their potential toxicity to mammalian cells. Conclusion: Among these hydrazonoyl derivatives, we identified the derivative (4) that showed trypanocidal activity (IC50/24 h = 15.0 µM) similar to Bz, the standard drug, and low toxicity to mammalian cells, reaching an SI value of 18.7.

scholarly journals EAPB0503: an imiquimod analog with potent in vitro activity against cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica

2020 ◽  
Vol 13 (12) ◽  
pp. 2112
Author(s):  
Rana El Hajj ◽  
Hanady Bou Youness ◽  
Laurence Lachaud ◽  
Patrick Bastien ◽  
Carine Masquefa ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Major ◽  
Vitro Activity ◽  
Leishmania Tropica ◽  
In Vitro Activity

scholarly journals EAPB0503: An Imiquimod analog with potent in vitro activity against cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica

2018 ◽  
Vol 12 (11) ◽  
pp. e0006854 ◽  
Author(s):  
Rana El Hajj ◽  
Hanady Bou Youness ◽  
Laurence Lachaud ◽  
Patrick Bastien ◽  
Carine Masquefa ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Major ◽  
Vitro Activity ◽  
Leishmania Tropica ◽  
In Vitro Activity

scholarly journals In vitro activity of Etanidazole against the protozoan parasite Trypanosoma cruzi

2004 ◽  
Vol 99 (2) ◽  
pp. 233-235 ◽  
Author(s):  
Patricia B Petray ◽  
María J Morilla ◽  
Ricardo S Corral ◽  
Eder L Romero
Keyword(s):  
Trypanosoma Cruzi ◽  
Protozoan Parasite ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruzi

2012 ◽  
Vol 107 (7) ◽  
pp. 946-950 ◽  
Author(s):  
Momodou Jobe ◽  
Charles Anwuzia-Iwegbu ◽  
Ama Banful ◽  
Emma Bosier ◽  
Mubeen Iqbal ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Trypanosoma Rangeli ◽  
Dna Topoisomerase ◽  
Topoisomerase Inhibitor

scholarly journals Antiprotozoal Activity of Turkish Origanum onites Essential Oil and Its Components

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4421 ◽  
Author(s):  
Tasdemir ◽  
Kaiser ◽  
Demirci ◽  
Demirci ◽  
Baser
Keyword(s):  
Gas Chromatography ◽  
Essential Oil ◽  
Mammalian Cells ◽  
Leishmania Donovani ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Flame Ionization ◽  
Main Component ◽  
Origanum Onites

Essential oil of Origanum species is well known for antimicrobial activity, but only a few have been evaluated in narrow spectrum antiprotozoal assays. Herein, we assessed the antiprotozoal potential of Turkish Origanum onites L. oil and its major constituents against a panel of parasitic protozoa. The essential oil was obtained by hydrodistillation from the dried herbal parts of O. onites and analyzed by Gas Chromatography-Flame Ionization Detector (GC-FID) and Gas Chromatography coupled with Mass Spectrometry (GC-MS). The in vitro activity of the oil and its major components were evaluated against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, and Plasmodium falciparum. The main component of the oil was identified as carvacrol (70.6%), followed by linalool (9.7%), p-cymene (7%), γ-terpinene (2.1%), and thymol (1.8%). The oil showed significant in vitro activity against T. b. rhodesiense (IC50 180 ng/mL), and moderate antileishmanial and antiplasmodial effects, without toxicity to mammalian cells. Carvacrol, thymol, and 10 additional abundant oil constituents were tested against the same panel; carvacrol and thymol retained the oil’s in vitro antiparasitic potency. In the T. b. brucei mouse model, thymol, but not carvacrol, extended the mean survival of animals. This study indicates the potential of the essential oil of O. onites and its constituents in the treatment of protozoal infections.

Manganese(II) complexes with N4-methyl-4-nitrobenzaldehyde, N4-methyl-4-nitroacetofenone, and N4-methyl-4-nitrobenzophenone thiosemicarbazone: Investigation of in vitro activity against Trypanosoma cruzi

Polyhedron ◽  
2010 ◽  
Vol 29 (10) ◽  
pp. 2232-2238 ◽  
Author(s):  
Denise da Gama Jaén Batista ◽  
Patrícia Bernardino da Silva ◽  
Daniela R. Lachter ◽  
Renata S. Silva ◽  
Ricardo Q. Aucelio ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
In Vitro Activity

Aromatic guanyl hydrazones: Synthesis, structural studies and in vitro activity against Trypanosoma cruzi

1995 ◽  
Vol 5 (24) ◽  
pp. 3079-3084 ◽  
Author(s):  
J.C. Messeder ◽  
L.W. Tinoco ◽  
J.D. Figueroa-Villar ◽  
E.M. Souza ◽  
R. Santa Rita ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
Structural Studies ◽  
In Vitro Activity
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