Sugar-binding Sites of the HA1 Subcomponent of Clostridium botulinum Type C Progenitor Toxin

2008 ◽  
Vol 376 (3) ◽  
pp. 854-867 ◽  
Author(s):  
Toshio Nakamura ◽  
Takashi Tonozuka ◽  
Azusa Ide ◽  
Takayuki Yuzawa ◽  
Keiji Oguma ◽  
...  
Keyword(s):  
Binding Sites ◽  
Clostridium Botulinum ◽  
Sugar Binding ◽  
Botulinum Type ◽  
Type C ◽  
Progenitor Toxin

Molecular diversity of the two sugar-binding sites of the β-trefoil lectin HA33/C (HA1) from Clostridium botulinum type C neurotoxin

2011 ◽  
Vol 512 (1) ◽  
pp. 69-77 ◽  
Author(s):  
Toshio Nakamura ◽  
Takashi Tonozuka ◽  
Sakae Ito ◽  
Yoichi Takeda ◽  
Ryutaro Sato ◽  
...  
Keyword(s):  
Binding Sites ◽  
Clostridium Botulinum ◽  
Molecular Diversity ◽  
Sugar Binding ◽  
Botulinum Type ◽  
Type C

The receptor and transporter for internalization of Clostridium botulinum type C progenitor toxin into HT-29 cells

2004 ◽  
Vol 319 (2) ◽  
pp. 327-333 ◽  
Author(s):  
Atsushi Nishikawa ◽  
Nobuo Uotsu ◽  
Hideyuki Arimitsu ◽  
Jae-Chul Lee ◽  
Yutaka Miura ◽  
...  
Keyword(s):  
Clostridium Botulinum ◽  
Botulinum Type ◽  
Type C ◽  
Ht 29 ◽  
Progenitor Toxin

Binding properties of Clostridium botulinum type C progenitor toxin to mucins

2007 ◽  
Vol 1770 (4) ◽  
pp. 551-555 ◽  
Author(s):  
Toshio Nakamura ◽  
Noriko Takada ◽  
Takashi Tonozuka ◽  
Yoshiyuki Sakano ◽  
Keiji Oguma ◽  
...  
Keyword(s):  
Clostridium Botulinum ◽  
Binding Properties ◽  
Botulinum Type ◽  
Type C ◽  
Progenitor Toxin

Crystal Structure of the HA3 Subcomponent of Clostridium botulinum Type C Progenitor Toxin

2009 ◽  
Vol 385 (4) ◽  
pp. 1193-1206 ◽  
Author(s):  
Toshio Nakamura ◽  
Mao Kotani ◽  
Takashi Tonozuka ◽  
Azusa Ide ◽  
Keiji Oguma ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Clostridium Botulinum ◽  
Botulinum Type ◽  
Type C ◽  
Progenitor Toxin

Characterization and reconstitution of functional hemagglutinin of the Clostridium botulinum type C progenitor toxin

2001 ◽  
Vol 268 (14) ◽  
pp. 4019-4026 ◽  
Author(s):  
Hirokazu Kouguchi ◽  
Toshihiro Watanabe ◽  
Yoshimasa Sagane ◽  
Tohru Ohyama
Keyword(s):  
Clostridium Botulinum ◽  
Botulinum Type ◽  
Type C ◽  
Progenitor Toxin

scholarly journals Oral toxicities of Clostridium botulinum type C and D toxins of different molecular sizes

1980 ◽  
Vol 28 (2) ◽  
pp. 303-309
Author(s):  
I Ohishi ◽  
G Sakaguchi
Keyword(s):  
Density Gradient ◽  
Clostridium Botulinum ◽  
Sucrose Density Gradient ◽  
Density Gradient Ultracentrifugation ◽  
Botulinum Toxins ◽  
Molecular Dissociation ◽  
Botulinum Type ◽  
Molecular Sizes ◽  
Type C ◽  
Progenitor Toxin

Clostridium botulinum type C progenitor toxins of different molecule sizes, C-L (16S) and C-M (12S), were purified from cultures of strains 573, Stockholm, and CB-19. C-L toxin showed some hemaggglutinin activity, whereas C-M toxin did not. Neither C-L nor C-M toxin was activated upon trypsinization. Molecular dissociation of purified type C-L and C-M toxins into toxic and nontoxic components was demonstrated by sucrose density gradient ultracentrifugation and diethylaminoethyl-Sephadex chromatography at pH 8.0. The molecular construction of type C progenitor toxin appears to be analogous to that reported for botulinum toxins of other types. C-L and D-L toxins showed higher oral toxicities to mice than did C-M or D-M toxin. Such higher oral toxicities were ascribed to the higher stabilities of these toxins in gastric and intestinal juices.

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