Miscoding Properties of 2′-Deoxyinosine, a Nitric Oxide-Derived DNA Adduct, during Translesion Synthesis Catalyzed by Human DNA Polymerases

2008 ◽  
Vol 377 (4) ◽  
pp. 1015-1023 ◽  
Author(s):  
Manabu Yasui ◽  
Emi Suenaga ◽  
Naoki Koyama ◽  
Chikahide Masutani ◽  
Fumio Hanaoka ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Dna Adduct ◽  
Human Dna

Translesion Synthesis past 2′-Deoxyxanthosine, a Nitric Oxide-derived DNA Adduct, by Mammalian DNA Polymerases

2004 ◽  
Vol 344 (3) ◽  
pp. 665-674 ◽  
Author(s):  
Manabu Yasui ◽  
Naomi Suzuki ◽  
Holly Miller ◽  
Tomonari Matsuda ◽  
Saburo Matsui ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Dna Adduct

scholarly journals Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine

2017 ◽  
Vol 292 (45) ◽  
pp. 18682-18688 ◽  
Author(s):  
Jung-Hoon Yoon ◽  
Jayati Roy Choudhury ◽  
Jeseong Park ◽  
Satya Prakash ◽  
Louise Prakash
Keyword(s):  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Minor Groove ◽  
Dna Adduct

Translesion Synthesis past Equine Estrogen-Derived 2‘-Deoxycytidine DNA Adducts by Human DNA Polymerases η and κ†

Biochemistry ◽  
2004 ◽  
Vol 43 (35) ◽  
pp. 11312-11320 ◽  
Author(s):  
Naomi Suzuki ◽  
Manabu Yasui ◽  
Y. R. Santosh Laxmi ◽  
Haruo Ohmori ◽  
Fumio Hanaoka ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Human Dna

scholarly journals Translesion Synthesis Across 1,N2-Ethenoguanine by Human DNA Polymerases

2006 ◽  
Vol 19 (6) ◽  
pp. 879-886 ◽  
Author(s):  
Jeong-Yun Choi ◽  
Hong Zang ◽  
Karen C. Angel ◽  
Ivan D. Kozekov ◽  
Angela K. Goodenough ◽  
...  
Keyword(s):  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Human Dna

Translesion Synthesis Past Estrogen-Derived DNA Adducts by Human DNA Polymerases η and κ†

Biochemistry ◽  
2004 ◽  
Vol 43 (20) ◽  
pp. 6304-6311 ◽  
Author(s):  
Naomi Suzuki ◽  
Shinji Itoh ◽  
Kinning Poon ◽  
Chikahide Masutani ◽  
Fumio Hanaoka ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Human Dna

Miscoding Properties of 6α- and 6β-Diastereoisomers of theN2-(Estradiol-6-yl)-2′-deoxyguanosine DNA Adduct by Y-Family Human DNA Polymerases†

Biochemistry ◽  
2008 ◽  
Vol 47 (25) ◽  
pp. 6695-6701 ◽  
Author(s):  
Kinning Poon ◽  
Shinji Itoh ◽  
Naomi Suzuki ◽  
Y. R. Santosh Laxmi ◽  
Itsuo Yoshizawa ◽  
...  
Keyword(s):  
Dna Polymerases ◽  
Dna Adduct ◽  
Human Dna ◽  
Y Family

scholarly journals Translesion Synthesis past Acrolein-derived DNA Adduct, γ-Hydroxypropanodeoxyguanosine, by Yeast and Human DNA Polymerase η

2002 ◽  
Vol 278 (2) ◽  
pp. 784-790 ◽  
Author(s):  
Irina G. Minko ◽  
M. Todd Washington ◽  
Manorama Kanuri ◽  
Louise Prakash ◽  
Satya Prakash ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Translesion Synthesis ◽  
Dna Adduct ◽  
Human Dna

scholarly journals Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy

2021 ◽  
Author(s):  
Jung-Hoon Yoon ◽  
Robert E. Johnson ◽  
Louise Prakash ◽  
Satya Prakash
Keyword(s):  
Adverse Effects ◽  
Cancer Cells ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Dna Adduct ◽  
Secondary Malignancies ◽  
Normal Cells ◽  
Cross Links ◽  
Y Family

Chemotherapy with cisplatin becomes limiting due to toxicity and secondary malignancies. In principle, therapeutics could be improved by targeting translesion synthesis (TLS) polymerases (Pols) that promote replication through intrastrand cross-links, the major cisplatin-induced DNA adduct. However, to specifically target malignancies with minimal adverse effects on normal cells, a good understanding of TLS mechanisms in normal versus cancer cells is paramount. We show that in normal cells, TLS through cisplatin intrastrand cross-links is promoted by Polη- or Polι-dependent pathways, both of which require Rev1 as a scaffolding component. In contrast, cancer cells require Rev1-Polζ. Our findings that a recently identified Rev1 inhibitor, JH-RE-06, purported to specifically disrupt Rev1 interaction with Polζ to block TLS through cisplatin adducts in cancer cells, abrogates Rev1's ability to function with Y family Pols as well, implying that by inactivating Rev1-dependent TLS in normal cells, this inhibitor will exacerbate the toxicity and tumorigenicity of chemotherapeutics with cisplatin.

scholarly journals Mechanism of Translesion Synthesis Past an Equine Estrogen-DNA Adduct by Y-Family DNA Polymerases

2007 ◽  
Vol 371 (5) ◽  
pp. 1151-1162 ◽  
Author(s):  
Manabu Yasui ◽  
Naomi Suzuki ◽  
Xiaoping Liu ◽  
Yoshinori Okamoto ◽  
Sung Yeon Kim ◽  
...  
Keyword(s):  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Dna Adduct ◽  
Y Family

scholarly journals Translesion Synthesis Past Tamoxifen-Derived DNA Adducts by Human DNA Polymerases η and κ†

Biochemistry ◽  
2006 ◽  
Vol 45 (39) ◽  
pp. 12167-12174 ◽  
Author(s):  
Manabu Yasui ◽  
Naomi Suzuki ◽  
Y. R. Santosh Laxmi ◽  
Shinya Shibutani
Keyword(s):  
Dna Adducts ◽  
Dna Polymerases ◽  
Translesion Synthesis ◽  
Human Dna
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