Forced degradation of fingolimod: Effect of co-solvent and characterization of degradation products by UHPLC-Q-TOF–MS/MS and 1H NMR

2015 ◽  
Vol 115 ◽  
pp. 388-394 ◽  
Author(s):  
Prinesh N. Patel ◽  
Pradipbhai D. Kalariya ◽  
S. Gananadhamu ◽  
R. Srinivas
Keyword(s):  
1H Nmr ◽  
Degradation Products ◽  
Forced Degradation ◽  
Tof Ms

Characterization of the stress degradation products of tolvaptan by UPLC-Q-TOF-MS/MS

RSC Advances ◽  
2015 ◽  
Vol 5 (27) ◽  
pp. 21142-21152 ◽  
Author(s):  
Prinesh N. Patel ◽  
D. Rajesh Kumar ◽  
S. Gananadhamu ◽  
R. Srinivas
Keyword(s):  
Degradation Products ◽  
Forced Degradation ◽  
Dry Heat ◽  
Stress Degradation ◽  
Tof Ms

TVT was subjected to forced degradation under hydrolysis, oxidation, dry heat and photolysis conditions and the degradation products (DPs) formed have been characterized through UPLC-PDA and UPLC-Q-TOF-MS/MS studies.

Characterization of Forced Degradation Products & Related Substances of Bilastine by Online LC-Q-TOF-MS and In-silico Study of Characterized Compounds

2021 ◽  
Vol 11 (4) ◽  
pp. 563-579
Author(s):  
Amrej Singh Yadav ◽  
Aishwarya Prabha ◽  
Divya Dornala ◽  
Debasish Swain ◽  
Dilep Kumar Sigalapalli ◽  
...  
Keyword(s):  
In Silico ◽  
Degradation Products ◽  
Forced Degradation ◽  
Related Substances ◽  
In Silico Study ◽  
Tof Ms

Characterization of forced degradation products of ketorolac tromethamine using LC/ESI/Q/TOF/MS/MS andin silicotoxicity prediction

2014 ◽  
Vol 49 (5) ◽  
pp. 380-391 ◽  
Author(s):  
Pradipbhai D. Kalariya ◽  
B. Raju ◽  
Roshan M. Borkar ◽  
Deepak Namdev ◽  
S. Gananadhamu ◽  
...  
Keyword(s):  
Degradation Products ◽  
Forced Degradation ◽  
Ketorolac Tromethamine ◽  
Tof Ms

Characterization of forced degradation products of pazopanib hydrochloride by UHPLC-Q-TOF/MS andin silicotoxicity prediction

2015 ◽  
Vol 50 (7) ◽  
pp. 918-928 ◽  
Author(s):  
Prinesh N. Patel ◽  
Pradipbhai D. Kalariya ◽  
Mahesh Sharma ◽  
Prabha Garg ◽  
M. V. N Kumar Talluri ◽  
...  
Keyword(s):  
Degradation Products ◽  
Forced Degradation ◽  
Tof Ms

Synthesis and Characterization of Potential and Degraded Impurities of Regadenoson

2020 ◽  
Vol 16 (8) ◽  
pp. 1130-1139
Author(s):  
Singaram Sathiyanarayanan ◽  
Chidambaram Subramanian Venkatesan ◽  
Senthamaraikannan Kabilan
Keyword(s):  
Mass Spectra ◽  
Degradation Products ◽  
Hplc Method ◽  
Forced Degradation ◽  
Spectroscopic Techniques ◽  
A2a Adenosine Receptor ◽  
Degradation Study ◽  
Related Substances ◽  
Adenosine Receptor Agonist

Background: Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator and commonly used as a pharmacologic cardiac stressing agents. Methods: HPLC method was used for the analysis of related substances. The degraded impurities during the process were isolated and characterized by IR, Mass and NMR spectral analysis. Results: Forced degradation study of regadenoson under conditions of hydrolysis (neutral, acidic and alkaline) and oxidations suggested in the ICH Q1A(R2) was accomplished. The drug showed significant degradation under all the above conditions. On the whole, five novel degradation products were found under diverse conditions along with process related impurities which were not reported earlier. Conclusion: All the degradation products were well characterized by using advanced spectroscopic techniques like IR, 1H NMR, 13C NMR and Mass spectra. The identification of these impurities will be productive for the quality control during the production and stability behavior of the regadenoson drug substance.

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