Characterization of the stress degradation products of tolvaptan by UPLC-Q-TOF-MS/MS

RSC Advances ◽  
2015 ◽  
Vol 5 (27) ◽  
pp. 21142-21152 ◽  
Author(s):  
Prinesh N. Patel ◽  
D. Rajesh Kumar ◽  
S. Gananadhamu ◽  
R. Srinivas
Keyword(s):  
Degradation Products ◽  
Forced Degradation ◽  
Dry Heat ◽  
Stress Degradation ◽  
Tof Ms

TVT was subjected to forced degradation under hydrolysis, oxidation, dry heat and photolysis conditions and the degradation products (DPs) formed have been characterized through UPLC-PDA and UPLC-Q-TOF-MS/MS studies.

Identification and structural characterization of the stress degradation products of omeprazole using Q-TOF-LC-ESI-MS/MS and NMR experiments: evaluation of the toxicity of the degradation products

2019 ◽  
Vol 43 (19) ◽  
pp. 7294-7306 ◽  
Author(s):  
G. Shankar ◽  
Roshan M. Borkar ◽  
Suresh Udutha ◽  
M. Kanakaraju ◽  
G. Sai Charan ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Proton Pump Inhibitor ◽  
Gastroesophageal Reflux ◽  
Degradation Products ◽  
Forced Degradation ◽  
Peptic Ulcers ◽  
Ich Guidelines ◽  
Stress Degradation ◽  
Forced Degradation Studies

Omeprazole (OMP), a prototype proton pump inhibitor used for the treatment of peptic ulcers and gastroesophageal reflux disease (GERD), was subjected to forced degradation studies as per ICH guidelines Q1A (R2).

Characterization of stress degradation products of blonanserin by UPLC-QTOF-tandem mass spectrometry

RSC Advances ◽  
2015 ◽  
Vol 5 (85) ◽  
pp. 69273-69288 ◽  
Author(s):  
Pradipbhai D. Kalariya ◽  
Prinesh N. Patel ◽  
Mahesh Sharma ◽  
Prabha Garg ◽  
R. Srinivas ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Tandem Mass Spectrometry ◽  
Degradation Products ◽  
Structural Elucidation ◽  
Forced Degradation ◽  
Tandem Mass ◽  
Degradation Study ◽  
Stress Degradation

Forced degradation study of blonanserin and structural elucidation of its degradation products was performed using high resolution tandem mass spectrometry.

Characterization of Forced Degradation Products & Related Substances of Bilastine by Online LC-Q-TOF-MS and In-silico Study of Characterized Compounds

2021 ◽  
Vol 11 (4) ◽  
pp. 563-579
Author(s):  
Amrej Singh Yadav ◽  
Aishwarya Prabha ◽  
Divya Dornala ◽  
Debasish Swain ◽  
Dilep Kumar Sigalapalli ◽  
...  
Keyword(s):  
In Silico ◽  
Degradation Products ◽  
Forced Degradation ◽  
Related Substances ◽  
In Silico Study ◽  
Tof Ms

Characterization of forced degradation products of ketorolac tromethamine using LC/ESI/Q/TOF/MS/MS andin silicotoxicity prediction

2014 ◽  
Vol 49 (5) ◽  
pp. 380-391 ◽  
Author(s):  
Pradipbhai D. Kalariya ◽  
B. Raju ◽  
Roshan M. Borkar ◽  
Deepak Namdev ◽  
S. Gananadhamu ◽  
...  
Keyword(s):  
Degradation Products ◽  
Forced Degradation ◽  
Ketorolac Tromethamine ◽  
Tof Ms
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