Study of chromatographic behavior of antibiotic drugs and their metabolites based on quantitative structure-retention relationships with the use of HPLC-DAD

2020 ◽  
Vol 184 ◽  
pp. 113187
Author(s):  
Justyna Walczak-Skierska ◽  
Małgorzata Szultka-Młyńska ◽  
Katarzyna Pauter ◽  
Bogusław Buszewski
Keyword(s):  
Chromatographic Behavior ◽  
Quantitative Structure ◽  
Antibiotic Drugs ◽  
Structure Retention ◽  
Quantitative Structure Retention Relationships

scholarly journals Estimation of lipophilicity and design of new 17β-carboxamide glucocorticoids using RP-HPLC and quantitative structure-retention relationships analysis

2021 ◽  
Author(s):  
Vladimir Dobričić ◽  
Jelena Bošković ◽  
Dragana Vukadinović ◽  
Sote Vladimirov ◽  
Olivera Čudina
Keyword(s):  
Inflammatory Activity ◽  
Chromatographic Behavior ◽  
Quantitative Structure ◽  
Retention Behavior ◽  
Rp Hplc ◽  
Mobile Phases ◽  
Structure Retention ◽  
Lipophilicity Prediction ◽  
Cyano Column ◽  
Quantitative Structure Retention Relationships

AbstractEight 17β-carboxamide glucocorticoids with local anti-inflammatory activity were selected and their retention behavior tested in six RP-HPLC systems (I–VI). logkw, a, and φ0 parameters were calculated and correlation with previously determined logPo/w values was examined. RP-HPLC system IV, which consisted of cyano column and methanol–water mobile phases (50:50, 60:40, 70:30, and 80:20, v/v), was selected as the most reliable for lipophilicity prediction and used for the analysis of chromatographic behavior of remaining fourteen 17β-carboxamide glucocorticoids. Quantitative structure-retention relationships analysis was performed and PLS(logkw) model was selected as the most statistically significant. On the basis of selected model and interpretation of corresponding descriptors, new derivatives with higher logkw values and higher expected lipophilicity were designed.

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