Combined Thyroidectomy and Renal Denervation Suppress Renin Expression and Secretion in Fetal Sheep

2006 ◽  
Vol 13 (8) ◽  
pp. 604-609
Author(s):  
Kai Chen ◽  
Luke C. Carey ◽  
Nancy K. Valego ◽  
Jingfang Liu ◽  
James C. Rose
Keyword(s):  
Renal Denervation ◽  
Fetal Sheep

Role of renal sympathetic nerves in response of the ovine fetus to volume expansion

1990 ◽  
Vol 259 (5) ◽  
pp. R1050-R1055 ◽  
Author(s):  
F. G. Smith ◽  
T. Sato ◽  
O. J. McWeeny ◽  
J. M. Klinkefus ◽  
J. E. Robillard
Keyword(s):  
Volume Expansion ◽  
Renal Denervation ◽  
Sympathetic Nerves ◽  
Renal Hemodynamics ◽  
Fetal Life ◽  
Renal Nerve ◽  
Fetal Sheep ◽  
Arterial Blood ◽  
Renal Sympathetic

To investigate the role of renal sympathetic nerves in the fetal response to hypervolemia, studies were carried out in conscious, chronically instrumented fetal sheep aged 137-142 days of gestation. Bilateral renal denervation (n = 9) or sham surgery (n = 8) was carried out under halothane anesthesia 3-6 days before experiments. Bilateral renal denervation did not alter basal fetal renal hemodynamics, glomerular filtration rate (GFR), or Na+ excretion. Volume expansion with 6% Dextran 70 (18 ml/kg) was associated with a fall in fetal hematocrit, a sustained increase in mean arterial blood pressure, and a sustained diuresis and natriuresis. There was no significant change in GFR during fetal hypervolemia from control levels of 4.51 +/- 0.74 ml/min (intact) and 4.43 +/- 0.43 ml/min (denervated). Atrial natriuretic factor increased from 144 +/- 34 to 464 +/- 134 pg/ml, and plasma renin activity decreased from 5.15 +/- 1.7 to 3.04 +/- 1.0 ng.ml-1.h-1 in intact animals, within 30 min of completion of the dextran infusion. Similar changes occurred in denervated fetuses. Plasma aldosterone levels remained constant in intact and denervated fetuses during hypervolemia at control levels of 40.8 +/- 5.4 and 59.3 +/- 8.4 pg/ml, respectively. These findings suggest that renal sympathetic nerves do not influence basal renal hemodynamics or function and do not appear to play an important role in the natriuretic response to volume expansion during fetal life. This can be explained by a low tonic renal nerve activity before birth.

Adenosine modulates plasma ACTH concentrations in fetal sheep

1998 ◽  
Vol 5 (1) ◽  
pp. 43A-43A
Author(s):  
A CHAU ◽  
J ROSE ◽  
B KOOS
Keyword(s):  
Plasma Acth ◽  
Fetal Sheep

Effects of betamethasone (βM) on adrenal blood flow in fetal sheep

1998 ◽  
Vol 5 (1) ◽  
pp. 156A-156A
Author(s):  
M SCHWAB ◽  
M ROEDEL ◽  
L BUCHWALDER ◽  
B WALTHER ◽  
P NATHANIELSZ
Keyword(s):  
Blood Flow ◽  
Fetal Sheep

Renal denervation - a clinical update and future directions

VASA ◽  
2013 ◽  
Vol 42 (4) ◽  
pp. 239-251
Author(s):  
Kai Mortensen ◽  
Klaas Franzen ◽  
Michael Reppel ◽  
Joachim Weil
Keyword(s):  
Renal Denervation ◽  
Future Directions ◽  
Scientific Background

The aim of this review is to give a contemporary update on renal denervation therapy focusing particularly on the scientific background and present literature as well as on different technical approaches and potential future directions.

Renal Denervation Therapy in a Resistant Hypertensive Patient-Report of First Case in Bangladesh

2012 ◽  
Vol 5 (1) ◽  
pp. 112-119
Author(s):  
M Ali ◽  
A Momen ◽  
PK Karmakar ◽  
MSR Patwary ◽  
MA Haque ◽  
...  
Keyword(s):  
Hypertensive Patient ◽  
Renal Denervation ◽  
Patient Report ◽  
First Case

Not available DOI: http://dx.doi.org/10.3329/cardio.v5i1.12282 Cardiovasc. j. 2012; 5(1): 112-119  

Sign in / Sign up

Export Citation Format

Share Document