Current Evidence Regarding the Treatment of Pediatric Lumbar Spondylolisthesis: A Report From the Scoliosis Research Society Evidence Based Medicine Committee

2017 ◽  
Vol 5 (5) ◽  
pp. 284-302 ◽  
Author(s):  
Charles H. Crawford ◽  
A. Noelle Larson ◽  
Marilyn Gates ◽  
R. Shay Bess ◽  
Tenner J. Guillaume ◽  
...  
Keyword(s):  
Evidence Based Medicine ◽  
Research Society ◽  
Current Evidence ◽  
Evidence Based ◽  
Scoliosis Research Society ◽  
Lumbar Spondylolisthesis ◽  
Based Medicine

Current Evidence Regarding Diagnostic Imaging Methods for Pediatric Lumbar Spondylolysis: A Report From the Scoliosis Research Society Evidence-Based Medicine Committee

2017 ◽  
Vol 5 (2) ◽  
pp. 97-101 ◽  
Author(s):  
Charles G.T. Ledonio ◽  
Douglas C. Burton ◽  
Charles H. Crawford ◽  
Robert Shay Bess ◽  
Jacob M. Buchowski ◽  
...  
Keyword(s):  
Diagnostic Imaging ◽  
Evidence Based Medicine ◽  
Research Society ◽  
Current Evidence ◽  
Evidence Based ◽  
Imaging Methods ◽  
Scoliosis Research Society ◽  
Lumbar Spondylolysis ◽  
Based Medicine

Current Evidence Regarding Diagnostic Methods for Pediatric Lumbar Spondylolysis: A Report from the Scoliosis Research Society Evidence Based Medicine Committee

2014 ◽  
Vol 14 (11) ◽  
pp. S141
Author(s):  
Charles Gerald T. Ledonio ◽  
Charles H. Crawford ◽  
Shay Bess ◽  
Jacob M. Buchowski ◽  
Douglas C. Burton ◽  
...  
Keyword(s):  
Evidence Based Medicine ◽  
Research Society ◽  
Diagnostic Methods ◽  
Current Evidence ◽  
Evidence Based ◽  
Scoliosis Research Society ◽  
Lumbar Spondylolysis ◽  
Based Medicine

Evidence-based medicine in anaesthesia

2017 ◽  
Author(s):  
Ann Merete Møller
Keyword(s):  
Evidence Based Medicine ◽  
Meta Analysis ◽  
Consort Statement ◽  
Current Evidence ◽  
Evidence Based ◽  
Clinical Question ◽  
Clinical Expertise ◽  
Clinical Databases ◽  
Patient Values ◽  
Based Medicine

Evidence-based medicine (EBM) is defined as ‘The judicious use of the best current evidence in making decisions about the care of individual patients’. Evidence-based medicine (EBM) is meant to integrate clinical expertise with the best available research evidence and patient values. The purpose of EBM is to assist clinicians in making the best decisions. Practising EBM includes asking an answerable, well-defined clinical question, searching for information, critically appraising information retrieved, extracting data, synthesizing data, and making conclusions about the overall effect. The clinical question includes information of the following elements: the population, the intervention, and the clinically relevant outcomes in focus. The clinical question is a tool to make the focus of the question clearer, and an aid to build the following search strategy. A comprehensive and reproducible literature search is essential for conducting a high-quality and up-to-date search. The search should include all relevant clinical databases. Papers retrieved after the search must be critically appraised and evaluated for the risk of bias. Evidence-based methods are used in the production of systematic reviews, and the development of clinical guidelines. Whether a meta-analysis should be performed depends on the quality and nature of the extracted data. Practising EBM may be challenged by a lack of well-performed trials, various types of bias (including publication bias), and heterogeneity between existing trials. Several tools have been constructed to help the process; examples are the CONSORT statement, the PRISMA statement, and the AGREE instrument.

scholarly journals Current Status of Cell-Based Therapy in Patients with Critical Limb Ischemia

2020 ◽  
Vol 21 (23) ◽  
pp. 8999
Author(s):  
Frantisek Jaluvka ◽  
Peter Ihnat ◽  
Juraj Madaric ◽  
Adela Vrtkova ◽  
Jaroslav Janosek ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Critical Limb Ischemia ◽  
Evidence Based Medicine ◽  
Odds Ratio ◽  
Limb Ischemia ◽  
Current Evidence ◽  
Evidence Based ◽  
Cell Based Therapy ◽  
Meta Analyses ◽  
Based Medicine

(1) Background: The treatment of peripheral arterial disease (PAD) is focused on improving perfusion and oxygenation in the affected limb. Standard revascularization methods include bypass surgery, endovascular interventional procedures, or hybrid revascularization. Cell-based therapy can be an alternative strategy for patients with no-option critical limb ischemia who are not eligible for endovascular or surgical procedures. (2) Aims: The aim of this narrative review was to provide an up-to-date critical overview of the knowledge and evidence-based medicine data on the position of cell therapy in the treatment of PAD. The current evidence on the cell-based therapy is summarized and future perspectives outlined, emphasizing the potential of exosomal cell-free approaches in patients with critical limb ischemia. (3) Methods: Cochrane and PubMed databases were searched for keywords “critical limb ischemia and cell therapy”. In total, 589 papers were identified, 11 of which were reviews and 11 were meta-analyses. These were used as the primary source of information, using cross-referencing for identification of additional papers. (4) Results: Meta-analyses focusing on cell therapy in PAD treatment confirm significantly greater odds of limb salvage in the first year after the cell therapy administration. Reported odds ratio estimates of preventing amputation being mostly in the region 1.6–3, although with a prolonged observation period, it seems that the odds ratio can grow even further. The odds of wound healing were at least two times higher when compared with the standard conservative therapy. Secondary endpoints of the available meta-analyses are also included in this review. Improvement of perfusion and oxygenation parameters in the affected limb, pain regression, and claudication interval prolongation are discussed. (5) Conclusions: The available evidence-based medicine data show that this technique is safe, associated with minimum complications or adverse events, and effective.

scholarly journals Antibody mediated rejection. Evidence based medicine. What is the current evidence?

2020 ◽  
Vol 35 (3) ◽  
Author(s):  
Maria Menezes ◽  
◽  
Inês Aires ◽  
Fernando Nolasco ◽  
◽  
...  
Keyword(s):  
Evidence Based Medicine ◽  
Current Evidence ◽  
Evidence Based ◽  
Antibody Mediated Rejection ◽  
Based Medicine
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