Impact of Additional Lipid-Lowering Therapy on New Ischemic Lesions of Diffusion-Weighted Imaging in Carotid Artery Stenting

2018 ◽  
Vol 27 (3) ◽  
pp. 764-770 ◽  
Author(s):  
Takashi Mizobe ◽  
Mitsugu Nakamura ◽  
Yasuhiko Motooka ◽  
Noriaki Ashida ◽  
Masahiro Sugihara
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Stenting ◽  
Diffusion Weighted Imaging ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
Lowering Therapy ◽  
Diffusion Weighted

Relationship between carotid plaque characteristics and new ischemic lesions after stenting detected by computed tomography angiography

2019 ◽  
Vol 61 (1) ◽  
pp. 47-55
Author(s):  
Hongying Qu ◽  
Xiaokun Zhang ◽  
Miao Zhang ◽  
Yongan Gao ◽  
Jie Lu
Keyword(s):  
Risk Factors ◽  
Computed Tomography ◽  
Carotid Artery ◽  
Carotid Artery Stenting ◽  
Carotid Plaque ◽  
Diffusion Weighted Imaging ◽  
Irregular Surface ◽  
Irregular Surfaces ◽  
Diffusion Weighted ◽  
Peripheral Position

Background Although carotid artery stenting achieves definite benefits, it carries a higher rate of embolization compared with carotid endarterectomy. The incidence of embolization may be related to plaque stability. Purpose To assess for any relationship between plaque characteristics and cerebral emboli following carotid artery stenting. Material and Methods Sixty-three patients with severe carotid stenosis underwent carotid artery stenting. They were divided into two groups according to whether new ischemic lesions were detected on diffusion-weighted imaging after carotid artery stenting. We evaluated the types and locations of calcification in plaques and extent of calcification. We then assessed for a correlation between each of these factors and occurrence of new lesions on diffusion-weighted imaging after carotid artery stenting. Results The locations of calcification, percentage of plaque enhancement, and the number of plaques with irregular surface or ulceration were significantly different between the two groups. A peripheral position of calcification (close to the adventitia), enhancing plaques, and plaques with irregular surfaces or ulceration were statistically significant predictors of intracerebral embolization after carotid artery stenting. No significant differences in type of plaque or degree of calcification were found between two groups. Conclusion Peripheral calcification, enhancing plaques, and plaques with irregular surfaces were risk factors for intracerebral embolization after carotid artery stenting. These plaque characteristics should be considered when choosing the optimal treatment for patients.

scholarly journals Carotid Anatomy Does Not Predict the Risk of New Ischaemic Brain Lesions on Diffusion-Weighted Imaging after Carotid Artery Stenting in the ICSS-MRI Substudy

2016 ◽  
Vol 51 (1) ◽  
pp. 14-20 ◽  
Author(s):  
D. Doig ◽  
B.M. Hobson ◽  
M. Müller ◽  
H.R. Jäger ◽  
R.L. Featherstone ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Stenting ◽  
Diffusion Weighted Imaging ◽  
Brain Lesions ◽  
Diffusion Weighted ◽  
Ischaemic Brain

scholarly journals Reduction in Arterial Wall Strain With Aggressive Lipid-Lowering Therapy in Patients With Carotid Artery Disease

2011 ◽  
Vol 75 (6) ◽  
pp. 1486-1492 ◽  
Author(s):  
Zhi-Yong Li ◽  
Tjun Y Tang ◽  
Fan Jiang ◽  
Yun Zhang ◽  
Jonathan H Gillard
Keyword(s):  
Carotid Artery ◽  
Arterial Wall ◽  
Carotid Artery Disease ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
Lowering Therapy ◽  
Artery Disease

scholarly journals Evaluation of ischemic lesions after carotid artery stenting with diffusion-weighted imaging

2020 ◽  
Vol 8 (10) ◽  
pp. 1859-1870 ◽  
Author(s):  
Murat Beyhan ◽  
Berat Acu ◽  
Erkan Gökçe ◽  
Mehmet Murat Fırat
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Stenting ◽  
Diffusion Weighted Imaging ◽  
Diffusion Weighted

Postinterventional microembolism signals detected by transcranial Doppler ultrasound after carotid artery stenting

VASA ◽  
2015 ◽  
Vol 44 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Michael Piorkowski ◽  
Christina Kläffling ◽  
Spiridon Botsios ◽  
Christoph Zerweck ◽  
Susanne Scheinert ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Carotid Artery ◽  
Antiplatelet Therapy ◽  
Doppler Ultrasound ◽  
Transcranial Doppler ◽  
Carotid Artery Stenting ◽  
Dual Antiplatelet Therapy ◽  
Transcranial Doppler Ultrasound ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy

Background: The occurrence of early post-procedural complications after carotid artery stenting (CAS) can be attributed to embolization of thrombus or plaque particles released from the stented segment. Vascular emboli can be non-invasively detected by transcranial Doppler ultrasound as microembolic signals (MES). We performed this study to discover factors predicting MES detected by transcranial Doppler (TCD)-monitoring within the early post-interventional phase. Patients and methods: In 134 consecutive patients undergoing CAS, transcranial Doppler monitoring of the ipsilateral middle cerebral artery was performed for MES detection during the first post-interventional hour. To identify clinical, morphologic, and procedure-related parameters likely to predict the occurrence of post-interventional MES a logistic regression analysis was performed. Results: In 134 patients (111 male, mean age 69.7 years) relevant MES were detected in 51 patients (38 %) with a median of 4 MES/h and a maximum of 62 MES/h. Three factors were observed to be associated with increased post-interventional MES-counts. These included symptomatic lesion (p < 0.05), elevated total cholesterol (p < 0.05), and aspirin monotherapy (p < 0.0005). In a binary logistic regression model, dual antiplatelet therapy (OR 5.6, p < 0.0005) and asymptomatic lesions (OR 2.6, p < 0.05) were revealed as independent predictors for the absence of post-interventional MES. Conclusions: Post-interventional MES were most likely in symptomatic lesions and patients with elevated cholesterol. The absence of an effective dual antiplatelet therapy and symptomatic lesions were revealed as independent predictors for post-interventional MES. An effective pre-interventional dual antiplatelet and lipid lowering therapy might improve the safety of CAS.

Effects of lipid lowering therapy on progression of coronary and carotid artery disease

1997 ◽  
Vol 8 (6) ◽  
pp. 354-361 ◽  
Author(s):  
Christie M. Ballantyne ◽  
J Alan Herd ◽  
J Kay Dunn ◽  
Peter H. Jones ◽  
John A. Farmer ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Disease ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
Lowering Therapy ◽  
Artery Disease

Age and the risk of new ischemic lesions on diffusion weighted imaging after carotid artery stenting: A systematic review and meta-analysis

2020 ◽  
Vol 195 ◽  
pp. 105881
Author(s):  
Xin Zhang ◽  
Yonggui Ge ◽  
Caihong Liang ◽  
Xin Chen ◽  
Yujie Wang
Keyword(s):  
Systematic Review ◽  
Carotid Artery ◽  
Carotid Artery Stenting ◽  
Diffusion Weighted Imaging ◽  
Meta Analysis ◽  
Diffusion Weighted
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