Abstract
Objective To examine XB130 and AKT expression levels in the pathological tissues of non-small cell lung cancer (NSCLC) followed by analysis of their relationship with other common prognostic indicators.Methods A retrospective analysis of the clinical and pathological characteristics of 120 NSCLC subjects from August 1, 2014 to August 1, 2015 was conducted. The expression of XB130 and AKT was detected by immunohistochemistry. Correlation analysis of XB130 with various other factors was analyzed by the Chi-squared test. Relationship between XB130, AKT and patient overall survival (OS), as well as progression-free survival (PFS) was examined using Cox analysis.Results The XB130 expression was significantly correlated to tumor differentiation (P = 0.004), T staging (P = 0.045), lymphatic metastasis (P = 0.028), and AKT expression (P = 0.043). Univariate analysis of the Cox proportional hazard model revealed that high XB130 expression, lymphatic metastasis, T staging, and high AKT expression were adverse prognostic factors for NSCLC (P < 0.05). Besides, the multivariate analysis demonstrated that high XB130 expression, lymph node metastasis, and high AKT expression were the independent prognostic factors (P < 0.05).Conclusion XB130, AKT, and lymph node metastasis are independent risk factors for NSCLC prognosis. XB130 might affect patient prognosis through AKT. XB130 may be a prognostic marker for the survival and a candidate for the treatment of NSCLC, with potential therapeutic prospects.
P3.16-002 Postoperative Prognostic Factors in Non-Small Cell Lung Cancer Patients with Lymph Node Metastasis
