Long chain 1-acyl-3-arylthioureas as jack bean urease inhibitors, synthesis, kinetic mechanism and molecular docking studies

2017 ◽  
Vol 77 ◽  
pp. 54-63 ◽  
Author(s):  
Aamer Saeed ◽  
Sajid-ur Rehman ◽  
Pervaiz Ali Channar ◽  
Fayaz Ali Larik ◽  
Qamar Abbas ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Kinetic Mechanism ◽  
Docking Studies ◽  
Urease Inhibitors ◽  
Jack Bean Urease ◽  
Jack Bean ◽  
Molecular Docking Studies ◽  
Long Chain

scholarly journals Synthesis, Urease Inhibition, Antioxidant, Antibacterial, and Molecular Docking Studies of 1,3,4-Oxadiazole Derivatives

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Muhammad Hanif ◽  
Khurram Shoaib ◽  
Muhammad Saleem ◽  
Nasim Hasan Rama ◽  
Sumera Zaib ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Potassium Hydroxide ◽  
Antioxidant Activities ◽  
Docking Studies ◽  
Potassium Salts ◽  
Jack Bean ◽  
Molecular Docking Studies ◽  
Oxadiazole Derivatives ◽  
Urease Inhibitory

A series of eighteen 1,3,4-oxadiazole derivatives have been synthesized by treating aromatic acid hydrazides with carbon disulfide in ethanolic potassium hydroxide yielding potassium salts of 1,3,4-oxadiazoles. Upon neutralization with 1 N hydrochloric acid yielded crude crystals of 1,3,4-oxadiazoles, which were purified by recrystallization in boiling methanol. The synthesized 1,3,4-oxadiazoles derivatives were evaluated in vitro for their urease inhibitory activities, most of the investigated compounds were potent inhibitors of Jack bean urease. The molecular docking studies were performed by docking them into the crystal structure of Jack bean urease to observe the mode of interaction of synthesized compounds. The synthesized compounds were also tested for antibacterial and antioxidant activities and some derivatives exhibited very promising results.

Semicarbazone derivatives as urease inhibitors: Synthesis, biological evaluation, molecular docking studies and in-silico ADME evaluation

2018 ◽  
Vol 79 ◽  
pp. 19-26 ◽  
Author(s):  
Syeda Uroos Qazi ◽  
Shafiq Ur Rahman ◽  
Asia Naz Awan ◽  
Mariya al-Rashida ◽  
Rima D. Alharthy ◽  
...  
Keyword(s):  
Molecular Docking ◽  
In Silico ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Urease Inhibitors ◽  
Molecular Docking Studies

Synthesis, molecular docking studies, and in vitro screening of sulfanilamide-thiourea hybrids as antimicrobial and urease inhibitors

2012 ◽  
Vol 22 (8) ◽  
pp. 3653-3662 ◽  
Author(s):  
Aamer Saeed ◽  
Sumera Zaib ◽  
Arshid Pervez ◽  
Amara Mumtaz ◽  
Mohammad Shahid ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Urease Inhibitors ◽  
In Vitro Screening ◽  
Molecular Docking Studies
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