Degradation of Selected Antidepressants Sertraline and Citalopram in Ultrapure Water and Surface Water Using Gamma Radiation

Gamma radiation was applied to degradation selected antidepressants in ultrapure water and surface water. Additionally, the influence of typical radical scavengers like carbonate, nitrate and humic acid was determined. The cytotoxicity towards liver cells HepG2 and colon cells Caco2 were measured during the radiation process. It was found that radiation technology, specifically ionizing radiation, can achieve satisfactory degradation efficiency with both SER and CIT. It was shown that the process of decomposition of the tested antidepressants with the highest efficiency occurs in the reaction with the hydroxyl radical.

Theoretical Studies on Anti-Oxidant Activity of the Phytochemical, Coumestrol and Its Derivatives

Free radical-induced changes in cellular and organ levels have been studied as a possible underlying cause of various adverse health conditions. Important research efforts have, therefore, been made to discover more powerful and potent antioxidants/free radical scavengers for the treatment of these adverse conditions. The phytoestrogen coumestrol intensively attracted scientific interest due to their efficient pharmacological activities. In this scenario, DFT studies were carried out to test the antiradical activities of coumestrol and its derivatives. The results obtained from FEDAM plots demonstrated that the coumestrol derivatives pointed out were good radical scavengers relative to the parent molecule in the gas phase. The derivatives whose 16thposition substituted with electron-donating groups like -NH2, -OCH3 and -CH3 showed good antioxidant capacity. Three antioxidant mechanisms, including hydrogen atom transfer (HAT), electron transfer followed by proton transfer (SET-PT), and sequential proton loss electron transfer (SPLET), were investigated by measuring thermodynamic parameters.

Thiophene and its Analogs as Prospective Antioxidant Agents: A Retrospect

: The field of Free Radical Chemistry has gained considerable interest in the current scenario. The formation of free radicals is attributable to different physiochemical factors, radiation exposure, pathological conditions, environmental contaminants, and as by-products of metabolized drugs. The concentration of free radicals is regulated strongly under normal conditions by physiological antioxidants. Free radicals may cause oxidative damage to proteins, lipids, sugars, and DNA when abundantly produced or when antioxidants are depleted. This imbalance of reduction-oxidation, referred to as oxidative stress, can change the body's physiological conditions and ultimately lead to tissue injury, further contributing to various disease pathologies. A proper balance between free radicals and antioxidants is required for an effective physiological process. The oxidation mechanism is chemically hindered by antioxidants; these are often called free radical scavengers. The application of an external antioxidant source is crucial in addressing the issue of oxidative stress. Plenty of naturally occurring, semi-synthetic, and synthetic antioxidants are used, and the search for an efficient, non-toxic, and safe antioxidant is stepped up over time. As an influential scaffold, thiophene and its derivatives have become a significant source of interest for researchers due to its substantial variety of biological activities. The versatility of thiophene moiety has been identified by an affluent unveiling of its derivatives with anti-inflammatory, antioxidant, anti-cancer, and antimicrobial behaviors. Thiophene activity has been influenced greatly by the nature and orientation of the substitutions. The current study aims at addressing various synthetic compounds with thiophene or condensed thiophene as a fundamental moiety or substituent as radical scavengers.

Aerobic Oxidative Desulfurization of Liquid Fuel Catalyzed by P–Mo–V Heteropoly Acids in the Presence of Aldehyde

Aerobic oxidative desulfurization (ODS) of model liquid fuel (dodecane spiked with dibenzothiophene (DBT)) was carried out in the presence of bulk and supported Keggin-type heteropoly acids H3+nPMo12-nVnO40 (HPA-n, n = 0–3) as heterogeneous catalysts and benzaldehyde as a sacrificial reductant. In the presence of bulk H4PMo11VO40 (HPA-1), 100% of DBT was removed from fuel (converted to DBT sulfone) at 60 °C and ambient air pressure. Multiple catalyst reuse without loss of activity was demonstrated. The ODS reaction was strongly inhibited by radical scavengers. An unbranched radical chain mechanism was proposed.

Amidinoquinoxaline-Based Nitrones as Lipophilic Antioxidants

The potential of nitrones (N-oxides) as therapeutic antioxidants is due to their ability to counteract oxidative stress, mainly attributed to their action as radical scavengers toward C- and O-centered radicals. Among them, nitrones from the amidinoquinoxaline series resulted in interesting derivatives, due to the ease with which it is possible to introduce proper substituents within their structure in order to modulate their lipophilicity. The goal is to obtain lipophilic antioxidants that are able to interact with cell membranes and, at the same time, enough hydrophilic to neutralize those radicals present in a water compartment. In this work, the antioxidant efficacy of a series of amidinoquinoxaline nitrones has been evaluated regarding the oxidation of 2-deoxyribose and lipid peroxidation. The results have been rationalized on the basis of the different possible mechanisms involved, depending on some of their properties, such as lipophilicity, the ability to scavenge free radicals, and to undergo single electron transfer (SET) reactions.

Dimethylated sulfur compounds in the Peruvian upwelling system

Our understanding of the biogeochemical cycling of the climate-relevant trace gas dimethylsulfide (DMS) in the Peruvian upwelling system is still limited. Here we present, oceanic and atmospheric DMS measurements which were made during two shipborne cruises in December 2012 (M91) and October 2015 (SO243) in the Peruvian upwelling region. Dimethylsulfoniopropionate (DMSP) and dimethylsulfoxide (DMSO) were also measured during M91. Relatively low DMS concentrations were measured in surface waters in October 2015 (1.9 ± 0.9 nmol L−1) and December 2012 (2.5 ± 1.9 nmol L−1). Nutrient availability appeared to be the main driver of the observed variability in the surface DMS distributions in the coastal areas. DMS, DMSP and DMSO showed maxima in the surface layer and no elevated concentrations associated with the oxygen minimum zone off Peru were measured. The possible role of DMS, DMSP and DMSO as radical scavengers (stimulated by nitrogen limitation) is supported by their negative correlations with N : P (sum of nitrate and nitrite: dissolved phosphate) ratios. Large variations in atmospheric DMS mole fractions were measured during M91 (144.6 ± 95.0 ppt) and SO243 (91.4 ± 55.8 ppt); however, the atmospheric mole fractions were generally low, and the sea-to-air flux density was primarily driven by seawater DMS. The Peruvian upwelling region was identified as a source of atmospheric DMS in December 2012 and October 2015, however, in comparison to the global monthly Lana climatology (mean: 6.2–9.8 μmol m−2 d−1 in October/December) (Lana et al., 2011), the Peru upwelling was not a hotspot of DMS emissions at either time (M91: 5.9 ± 5.3 μmol m−2 d−1; SO243: 3.8 ± 2.7 μmol m−2 d−1).

Varietal Evaluation, Calyces Yield and Jam Preparation from Roselle (Hibiscus subdariffa L.)

Roselle (Hibiscus subdariffa L.) has been used in number of dishes, beverages and conventional remedy of diseases for centuries. It is popular for its edible fleshy calyces and leaves that are used for making salads, tea, juices, jams, jellies, icecreams and many other products. In many countries of the world fresh calyces of roselle are harvested to produce pro health drink due to its high vitamin C and anthocyanins contents. But in bangaladesh roselle leaves and calyces are used as vegetables and its fibre is used as jute substitute. Roselle is also famous for its high nutritional and medicinal values. Nutritional analysis of calyces of roselle showed that they are high in calcium, iron, niacin, and riboflavin. It is also a source of antioxidants, anthocyanins which acts as free radical scavengers and inhibit lipid per-oxidation. Roselle is a multipurpose crop and has great potential to increase the income of farmers, producers, processors by fetching high market price both from export and local market.

Plant Antioxidants for Food Safety and Quality: Exploring New Trends of Research

Antioxidants are an heterogeneous group of compounds able to counteract cell oxidation by acting as reducing agents, as free radical scavengers, and quenchers of radical species and other pro-oxidants, such as metals [...]