Health-Related Quality of Life after Major Lower Extremity Amputation Due to Musculoskeletal Tumors

Background: Diabetic foot ulcers, foot infection, Charcot foot arthropathy, and lower extremity amputation have a severe negative effect on the health-related quality of life in individuals with diabetes. The purpose of this study was to determine if there is a relationship between these negative effects and cognitive impairment or clinical depression. Methods: Sixty adults with diabetes completed the Short Form 36 (SF-36) Health Survey questionnaire, two screening examinations for cognitive function (Mini Mental Exam and Clock-Drawing Test), and a screening examination for depression (Zung Self-Rating Depression Scale). The two focus groups were composed of 20 subjects each who were undergoing treatment for (1) diabetic foot ulcers or active Charcot foot arthropathy or (2) lower extremity amputation. Twenty diabetic individuals without foot-related morbidity but with evidence of peripheral neuropathy as measured by insensitivity to the Semmes-Weinstein 5.07 (10 gm) monofilament comprised the control group. Results: The SF-36 Health Survey score was significantly impaired in both the diabetic foot ulcer and Charcot arthropathy group ( p < 0.001) and amputee ( p < 0.000) group. There was no evidence of cognitive impairment or depression in either group. The negative impact on health-related quality of life was similar in both focus groups ( p < 0.314). Conclusion: The results of this preliminary study suggest that the negative impact on health-related quality of life in diabetic patients with foot ulcers or Charcot foot arthropathy may be as severe as in similar patients with lower extremity amputation. The negative effect did not seem to cause cognitive impairment or clinical depression in either focus group.

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The course of health status and (health-related) quality of life following fracture of the lower extremity: a 6-month follow-up study

Quality of Life Research ◽

10.1007/s11136-015-1167-4 ◽

2015 ◽

Vol 25 (5) ◽

pp. 1285-1294 ◽

Cited By ~ 4

Author(s):

M. A. C. Van Son ◽

J. De Vries ◽

J. A. Roukema ◽

T. Gosens ◽

M. H. J. Verhofstad ◽

...

Keyword(s):

Quality Of Life ◽

Health Status ◽

Lower Extremity ◽

Health Related Quality ◽

Follow Up Study ◽

Related Quality ◽

Health Related

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Health related quality of life and return to work after minor extremity injuries: A longitudinal study comparing upper versus lower extremity injuries

Injury ◽

10.1016/j.injury.2016.02.019 ◽

2016 ◽

Vol 47 (4) ◽

pp. 824-831 ◽

Cited By ~ 15

Author(s):

Kerstin Prignitz Sluys ◽

Justine Shults ◽

Therese S. Richmond

Keyword(s):

Quality Of Life ◽

Longitudinal Study ◽

Lower Extremity ◽

Return To Work ◽

Health Related Quality ◽

Lower Extremity Injuries ◽

Related Quality ◽

Health Related ◽

Extremity Injuries

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Psychometric validation of the Korean version of PROMIS 29 Profile V2.1 among patients with lower extremity problems

BMC Sports Science Medicine and Rehabilitation ◽

10.1186/s13102-021-00374-1 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Youngha Kim ◽

Danbee Kang ◽

Eunjee Kang ◽

Jihyun Lim ◽

Sooyeon Kim ◽

...

Keyword(s):

Quality Of Life ◽

Lower Extremity ◽

Psychometric Validation ◽

Outpatient Clinics ◽

Health Related Quality ◽

Korean Version ◽

Patient Reported ◽

Related Quality ◽

Health Related

Abstract Background Patients with lower extremity problems (LEP) commonly experience functional loss, pain, decreased range of motion, inadequacy in daily living activities, and structural change in radiographic evaluations. However, the traditional patient-reported outcome measurement which focused on symptoms, had a limited scope of applicability. This study aimed to validate the psychometric properties of the Korean version of PROMIS-29 Profile v2.1 (K-PROMIS-29 V2.1), a multi-dimensional measure for assessing generic profile health-related quality-of-life (HRQoL) in a sample of patients with lower extremity problems (LEP). Methods Participants were recruited from the orthopedic outpatient clinics at the Samsung Medical Center in Seoul, South Korea from September to October 2018. Participants completed a survey questionnaire that included the K-PROMIS-29 V2.1 and the SF-36v2. Principal component analysis (PCA) and confirmatory factor analysis (CFA) and Pearson’s correlations were used to evaluate the reliability and validity of the K-PROMIS-29 V2.1. Results A total of 299 participants were enrolled in the study and 258 (86%) completed the study questionnaire. The mean age (SD) of the participants was 56.6 (14.5) and 32.3%, 29.8, and 25.2% of the study participants visited outpatient clinics for foot, knee, and hip problems respectively. The Cronbach’s alpha coefficients of 7 sub-domains in K-PROMIS-29 V2.1 ranged from 0.80 to 0.95, indicating satisfactory internal consistency. In CFA, the goodness-of-fit indices were high (CFI = 0.937 and SRMR = 0.061). High to moderate correlations were found between comparable subscales of the K-PROMIS-29 V2.1 and subscales of the SF-36v2 (r = 0.55–0.70). Conclusions The K-PROMIS-29 V2.1 is a reliable and valid measure for assessing a broad range of health-related quality-of-life domains in patients with LEP. It would reflect the real-life symptoms experienced by patients with LEP.

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Health-related quality of life (HRQoL) after stroke: Positive relationship between lower extremity and balance recovery

Topics in Stroke Rehabilitation ◽

10.1080/10749357.2020.1726070 ◽

2020 ◽

Vol 27 (7) ◽

pp. 534-540

Author(s):

Alex Martino Cinnera ◽

Sonia Bonnì ◽

Maria Concetta Pellicciari ◽

Francesco Giorgi ◽

Carlo Caltagirone ◽

...

Keyword(s):

Quality Of Life ◽

Lower Extremity ◽

Positive Relationship ◽

Health Related Quality ◽

Balance Recovery ◽

Related Quality ◽

Health Related

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Assessment of health-related quality of life among patients undergoing peripheral percutaneous intervention: The ALEVE Aassessment of Lower Extremity reVascularization outcomEs) study

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(03)82811-5 ◽

2003 ◽

Vol 41 (6) ◽

pp. 522 ◽

Cited By ~ 1

Author(s):

Roberto A. Corpus ◽

John A. House ◽

William C. Daniels ◽

Steven B. Laster ◽

John A. Spertus ◽

...

Keyword(s):

Quality Of Life ◽

Lower Extremity ◽

Percutaneous Intervention ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Outcomes Study ◽

Lower Extremity Revascularization

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Health-related quality-of-life improvement with lumbar fusion in patients with lower-extremity arthritis

Journal of Neurosurgery Spine ◽

10.3171/2020.6.spine20759 ◽

2021 ◽

Vol 34 (1) ◽

pp. 60-65

Author(s):

Mladen Djurasovic ◽

Steven Glassman ◽

Jeffrey L. Gum ◽

Charles H. Crawford ◽

R. Kirk Owens ◽

...

Keyword(s):

Quality Of Life ◽

Lower Extremity ◽

Lumbar Fusion ◽

Low Back ◽

Health Related Quality ◽

Meaningful Improvement ◽

Patient Reported ◽

Related Quality ◽

Health Related

OBJECTIVELumbar fusion can lead to significant improvements in patient-reported outcomes (PROs) in patients with degenerative conditions. It is unknown whether the presence of hip or knee arthritis confounds the responses of patients to low-back–specific PROs. This study examined PROs with lumbar fusion in patients with concomitant lower-extremity arthritis. The purpose of the current study was to examine whether patients with significant lower-extremity arthritis who undergo lumbar fusion achieve similar improvements in low-back–specific PROs compared to patients without lower-extremity arthritis.METHODSPatients were identified from a prospectively enrolled multicenter registry of patients undergoing lumbar fusion surgery for degenerative conditions. Two hundred thirty patients identified with lumbar fusion and who also had concomitant lower-extremity arthritis were propensity matched to 233 patients who did not have lower-extremity arthritis based on age, BMI, sex, smoking status, American Society of Anesthesiologists grade, number of levels fused, and surgical approach. One-year improvement in PROs, numeric rating scales (0–10) for back and leg pain, and the Oswestry Disability Index and EuroQol-5D scores were compared for patients with and without lower-extremity arthritis.RESULTSBaseline demographics and preoperative outcome measures did not differ between the two propensity-matched groups with 110 cases each. Patients with concomitant lower-extremity arthritis achieved similar improvement in health-related quality-of-life measures to patients without lower-extremity arthritis, with no significant differences between the groups (p > 0.10).CONCLUSIONSThe presence of lower-extremity arthritis does not adversely affect the results of lumbar fusion in properly selected patients. Patients with lower-extremity arthritis who undergo lumbar fusion can achieve meaningful improvement in PROs similar to patients without arthritis.

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