PCN39 TREATMENT EFFECT MODIFICATION OF IMMUNOTHERAPY-BASED REGIMENS IN FIRST-LINE (1L) ADVANCED NON-SMALL CELL LUNG CANCER (ANSCLC): A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS (RCTS)

2020 ◽  
Vol 23 ◽  
pp. S29
Author(s):  
S.M. Goring ◽  
N. Waser ◽  
N. Varol ◽  
J.R. Penrod ◽  
Y. Yuan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Systematic Review ◽  
Small Cell Lung Cancer ◽  
Treatment Effect ◽  
Effect Modification ◽  
Small Cell ◽  
Controlled Trials ◽  
Small Cell Lung ◽  
First Line ◽  
Randomized Controlled

scholarly journals Indirect analysis of first-line therapy for advanced non-small-cell lung cancer with activating mutations in the Japanese population

2020 ◽  
Author(s):  
Kazuhiko Nakagawa ◽  
Koichi Matsumura ◽  
Tayler Scory ◽  
Megan S Farris ◽  
Kelly A Larkin-Kaiser ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Meta Analysis ◽  
Small Cell ◽  
Controlled Trials ◽  
Small Cell Lung ◽  
First Line ◽  
Randomized Controlled ◽  
Egfr Tkis

Background: Five EGFR-tyrosine kinase inhibitors ( EGFR TKIs) are currently available in the first-line setting for non-small-cell lung cancer (NSCLC) in Japan. The aim here was to compare the relative efficacy of EGFR TKIs in the Japanese population. Materials & methods: A systematic review identified randomized controlled trials examining the efficacy of first-line EGFR TKIs. A Bayesian network meta-analysis was used to assess these EGFR TKI comparisons for progression-free survival (PFS). Results: A total of seven randomized controlled trials were identified and considered for network meta-analysis. Dacomitinib showed a trend toward improved PFS versus all comparators. Conclusion: Dacomitinib demonstrated a trend toward improved PFS and therefore, should be considered one of the standard first-line therapies for Japanese patients diagnosed with EGFR+ non-small-cell lung cancer.

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