TP53 mutation in allogeneic hematopoietic cell transplantation for de novo myelodysplastic syndrome

2018 ◽  
Vol 74 ◽  
pp. 97-104
Author(s):  
Yoo-Jin Kim ◽  
Seung-Hyun Jung ◽  
Eun-Hye Hur ◽  
Eun-Ji Choi ◽  
Kyoo-Hyung Lee ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Cell Transplantation ◽  
Tp53 Mutation ◽  
Hematopoietic Cell Transplantation ◽  
De Novo ◽  
Hematopoietic Cell ◽  
Allogeneic Hematopoietic Cell Transplantation

scholarly journals Multiple donor-derived leukemias in a recipient of allogeneic hematopoietic cell transplantation for myeloid malignancy

2020 ◽  
Vol 4 (19) ◽  
pp. 4798-4801
Author(s):  
Ibrahim Aldoss ◽  
Joo Y. Song ◽  
Peter T. Curtin ◽  
Stephen J. Forman
Keyword(s):  
Transplant Recipient ◽  
Myelodysplastic Syndrome ◽  
Cell Transplantation ◽  
Malignant Transformation ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Allogeneic Hematopoietic Cell Transplantation ◽  
Myeloid Malignancy ◽  
Key Points

Key Points A patient with myelodysplastic syndrome was transplanted twice and developed clonally unrelated relapse each time in donor-derived cells. This case supports the concept that a leukemogenic marrow environment may predispose the transplant recipient to malignant transformation.

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