Treatment of essential hypertension and non-insulin dependent diabetes mellitus with vitamin C

2007 ◽  
Vol 68 (5) ◽  
pp. 1126-1133 ◽  
Author(s):  
Narayan V. Nimbkar ◽  
Fatimah Lateef
Keyword(s):  
Diabetes Mellitus ◽  
Essential Hypertension ◽  
Vitamin C ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

scholarly journals The roles of cell Ca2+, protein kinase C and the Na(+)-H+ antiport in the development of hypertension and insulin resistance.

1992 ◽  
Vol 3 (5) ◽  
pp. 1049-1063
Author(s):  
A Aviv
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Protein Kinase C ◽  
Essential Hypertension ◽  
Protein Kinase ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Kinase C ◽  
Insulin Dependent

There is evidence that the cytosolic free Ca2+, protein kinase C, and the Na(+)-H+ antiport cross-communicate with one another through positive and negative feedback mechanisms, thereby maintaining cellular Ca2+ and pH homeostasis. This triumvirate may play a role in the development of insulin resistance--a common characteristic of both essential hypertension and non-insulin-dependent diabetes mellitus. Circulating cells from patients with essential hypertension and non-insulin-dependent diabetes mellitus demonstrate elevated cytosolic free Ca2+, increased protein kinase C activity, or both, and these perturbations are associated with augmented activity of the Na(+)-H+ antiport. If present in other cells (e.g., striated muscle cells and adipocytes), these alterations could underlie insulin resistance in essential hypertension and non-insulin-dependent diabetes mellitus.

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