scholarly journals 03-P093 Tbx2 modulates proliferation and elongation of the mouse embryonic heart tube

2009 ◽  
Vol 126 ◽  
pp. S94
Author(s):  
Laurent Dupays ◽  
Surendra Kotecha ◽  
Timothy Mohun
Keyword(s):  
Embryonic Heart ◽  
Heart Tube

Cardiac embryogenesis

ESC CardioMed ◽  
2018 ◽  
pp. 33-36
Author(s):  
Robert G. Kelly
Keyword(s):  
Progenitor Cells ◽  
Progenitor Cell ◽  
Congenital Heart ◽  
Heart Defects ◽  
Embryonic Heart ◽  
Heart Tube ◽  
Second Heart Field ◽  
Heart Field ◽  
Cell Niche ◽  
The Right

The embryonic heart forms in anterior lateral splanchnic mesoderm and is derived from Mesp1-expressing progenitor cells. During embryonic folding, the earliest differentiating progenitor cells form the linear heart tube in the ventral midline. The heart tube extends in length and loops to the right as new myocardium is progressively added at the venous and arterial poles from multipotent second heart field cardiovascular progenitor cells in contiguous pharyngeal mesoderm. While the linear heart tube gives rise to the left ventricle, the right ventricle, outflow tract, and a large part of atrial myocardium are derived from the second heart field. Progressive myocardial differentiation is controlled by intercellular signals within the progenitor cell niche. The embryonic heart is the template for septation and growth of the four-chambered definitive heart and defects in progenitor cell deployment result in a spectrum of common forms of congenital heart defects.

Study of Beloussov’s Hyper-Restoration Hypothesis for Regulation of Embryonic Heart Bending

2010 ◽  
Author(s):  
Ashok Ramasubramanian ◽  
Larry A. Taber
Keyword(s):  
Heart Development ◽  
Embryonic Heart ◽  
Developmental Phase ◽  
Heart Tube ◽  
Shaped Tube

During cardiac c-looping, an important developmental phase in early heart development, the initially straight heart tube (HT) is transformed into a c-shaped tube. Two distinct processes, ventral bending and dextral rotation, constitute c-looping. Previous research suggests that ventral bending is likely driven by forces that are intrinsic to the heart while dextral rotation is driven by forces applied by a pair of omphalomesenteric veins that flank the heart tube and a membrane called the splanchnopleure that lies on top of the heart.

Cardiac embryogenesis

ESC CardioMed ◽  
2018 ◽  
pp. 33-36
Author(s):  
Robert G. Kelly
Keyword(s):  
Progenitor Cells ◽  
Progenitor Cell ◽  
Congenital Heart ◽  
Heart Defects ◽  
Embryonic Heart ◽  
Heart Tube ◽  
Second Heart Field ◽  
Heart Field ◽  
Cell Niche ◽  
The Right

The embryonic heart forms in anterior lateral splanchnic mesoderm and is derived from Mesp1-expressing progenitor cells. During embryonic folding, the earliest differentiating progenitor cells form the linear heart tube in the ventral midline. The heart tube extends in length and loops to the right as new myocardium is progressively added at the venous and arterial poles from multipotent second heart field cardiovascular progenitor cells in contiguous pharyngeal mesoderm. While the linear heart tube gives rise to the left ventricle, the right ventricle, outflow tract, and a large part of atrial myocardium are derived from the second heart field. Progressive myocardial differentiation is controlled by intercellular signals within the progenitor cell niche. The embryonic heart is the template for septation and growth of the four-chambered definitive heart and defects in progenitor cell deployment result in a spectrum of common forms of congenital heart defects.

Computational Model for the Transition From Peristaltic to Pulsatile Flow in the Embryonic Heart Tube

2006 ◽  
Vol 129 (3) ◽  
pp. 441-449 ◽  
Author(s):  
Larry A. Taber ◽  
Jinmei Zhang ◽  
Renato Perucchio
Keyword(s):  
Computational Model ◽  
Pulsatile Flow ◽  
Embryonic Heart ◽  
Single Muscle ◽  
Heart Tube ◽  
Endocardial Cushions ◽  
Form And Function ◽  
Flow Parameters ◽  
And Function ◽  
Good Agreement

Early in development, the heart is a single muscle-wrapped tube without formed valves. Yet survival of the embryo depends on the ability of this tube to pump blood at steadily increasing rates and pressures. Developmental biologists historically have speculated that the heart tube pumps via a peristaltic mechanism, with a wave of contraction propagating from the inflow to the outflow end. Physiological measurements, however, have shown that the flow becomes pulsatile in character quite early in development, before the valves form. Here, we use a computational model for flow though the embryonic heart to explore the pumping mechanism. Results from the model show that endocardial cushions, which are valve primordia arising near the ends of the tube, induce a transition from peristaltic to pulsatile flow. Comparison of numerical results with published experimental data shows reasonably good agreement for various pressure and flow parameters. This study illustrates the interrelationship between form and function in the early embryonic heart.

Wall Motion Influences Flow Pattern in the Outflow Tract of the Chick Embryonic Heart Tube

2010 ◽  
Author(s):  
Aiping Liu ◽  
Ruikang Wang ◽  
Kent Thornburg ◽  
Sandra Rugonyi
Keyword(s):  
Blood Flow ◽  
Heart Development ◽  
Muscle Layer ◽  
Distal Region ◽  
Embryonic Heart ◽  
Outflow Tract ◽  
Flow Dynamics ◽  
Heart Tube ◽  
Blood Flow Dynamics ◽  
Heart Functions

The outflow tract (OFT) of the chick embryonic heart offers a good model system to study the association between blood flow dynamics and cardiac morphogenesis in early heart development. At early stages, the chick heart is a looped tube without valves. The OFT, the distal region of the heart, functions as a primitive valve [1]. The OFT is a slightly curved tube with three-layered wall (Fig. 1 (A) and (B)): the myocardium, an external muscle layer that actively contracts; the endocardium, an inner endothelial layer that directly contacts blood; in between the cardiac jelly, an extracellular matrix layer. The OFT undergoes complex morphogenesis, eventually leading to the development of semilunar valves, and this morphogenesis is sensitive to blood flow dynamics.

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