Characterization of human malaria parasite Plasmodium falciparum eIF4E homologue and mRNA 5′ cap status

2007 ◽  
Vol 155 (2) ◽  
pp. 146-155 ◽  
Author(s):  
Philip J. Shaw ◽  
Napawan Ponmee ◽  
Nitsara Karoonuthaisiri ◽  
Sumalee Kamchonwongpaisan ◽  
Yongyuth Yuthavong
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Parasite ◽  
Human Malaria Parasite ◽  
Human Malaria ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum

scholarly journals Characterization of the accessible genome in the human malaria parasite Plasmodium falciparum

2018 ◽  
Vol 46 (18) ◽  
pp. 9414-9431 ◽  
Author(s):  
José Luis Ruiz ◽  
Juan J Tena ◽  
Cristina Bancells ◽  
Alfred Cortés ◽  
José Luis Gómez-Skarmeta ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Parasite ◽  
Human Malaria Parasite ◽  
Human Malaria ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum

scholarly journals Characterization of class II apurinic/apyrimidinic endonuclease activities in the human malaria parasite, Plasmodium falciparum

1999 ◽  
Vol 345 (1) ◽  
pp. 85-89 ◽  
Author(s):  
Brett M. HALTIWANGER ◽  
Natalie O. KARPINICH ◽  
Theodore F. TARASCHI
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Parasite ◽  
Class Ii ◽  
Human Malaria Parasite ◽  
Human Malaria ◽  
Starting Point ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum ◽  
Ap Sites

We have reported that the human malaria parasite, Plasmodium falciparum, repairs apurinic/apyrimidinic (AP) sites on DNA by a long-patch base excision repair (BER) pathway. This biology is different from that in mammalian cells, which predominantly repair AP sites by a DNA-polymerase-β-dependent, one-nucleotide patch BER pathway. As a starting point for the identification and biochemical characterization of the enzymes involved in the parasite DNA BER pathway, we chose characterization of the AP endonuclease activity in a P. falciparum cell-free lysate. Evidence is provided for the presence of class II, Mg2+-dependent and independent AP endonucleases in the parasite lysate. The investigation of the processing of AP sites in Plasmodium will provide new information about long-patch BER pathways; if they are different from those in the human host they might provide a new target for anti-malarial chemotherapy.

Molecular cloning and characterization of a peroxiredoxin from the human malaria parasite Plasmodium falciparum

2000 ◽  
Vol 109 (2) ◽  
pp. 165-169 ◽  
Author(s):  
Shin-ichiro Kawazu ◽  
Naotoshi Tsuji ◽  
Toshimitsu Hatabu ◽  
Satoru Kawai ◽  
Yoshitsugu Matsumoto ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Molecular Cloning ◽  
Malaria Parasite ◽  
Human Malaria Parasite ◽  
Human Malaria ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum
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