Structure and organization of the T cell receptor alpha chain genes in Atlantic salmon

2004 ◽  
Vol 41 (5) ◽  
pp. 553-559 ◽  
Author(s):  
Ivar Hordvik ◽  
Jannicke Torvund ◽  
Lindsey Moore ◽  
Curt Endresen
Keyword(s):  
T Cell ◽  
Atlantic Salmon ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Receptor Alpha Chain ◽  
Cell Receptor Alpha

scholarly journals Deletional rearrangement in the human T-cell receptor alpha-chain locus.

1987 ◽  
Vol 84 (23) ◽  
pp. 8608-8612 ◽  
Author(s):  
J. P. de Villartay ◽  
D. Lewis ◽  
R. Hockett ◽  
T. A. Waldmann ◽  
S. J. Korsmeyer ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Chain Locus ◽  
Human T Cell ◽  
Receptor Alpha Chain ◽  
Cell Receptor Alpha

scholarly journals Diversity and structure of human T-cell receptor alpha-chain variable region genes.

1987 ◽  
Vol 84 (19) ◽  
pp. 6884-6888 ◽  
Author(s):  
M. H. Klein ◽  
P. Concannon ◽  
M. Everett ◽  
L. D. Kim ◽  
T. Hunkapiller ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Variable Region ◽  
Cell Receptor ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Human T Cell ◽  
Variable Region Genes ◽  
Receptor Alpha Chain ◽  
Cell Receptor Alpha

scholarly journals T cell receptor alpha chain genes are located on chromosome 14 at 14q11-14q12 in humans.

1985 ◽  
Vol 161 (5) ◽  
pp. 1255-1260 ◽  
Author(s):  
N Caccia ◽  
G A Bruns ◽  
I R Kirsch ◽  
G F Hollis ◽  
V Bertness ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chromosome 14 ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Human T Cell ◽  
Receptor Alpha Chain ◽  
Cell Receptor Alpha

A cDNA clone encoding the alpha chain of the human T cell receptor was used in connection with somatic cell human-rodent hybrids to determine that the genes coding for the alpha chain are located on chromosome 14 in humans. In situ hybridization confirms this result and further localizes these genes to 14q11-14q12 on this chromosome. Since this region of chromosome has been shown to be nonrandomly involved in a number of T cell neoplasias, this assignment raises a number of interesting questions as to the possible involvement of the T cell receptor alpha chain genes in tumorigenesis.

Discordance of the T-cell receptor alpha-chain gene in familial multiple sclerosis

Neurology ◽  
1992 ◽  
Vol 42 (4) ◽  
pp. 839-839 ◽  
Author(s):  
S. G. Lynch ◽  
J. W. Rose ◽  
J. H. Petajan ◽  
M. Leppert
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Receptor Alpha Chain ◽  
Cell Receptor Alpha

scholarly journals Sequences and repertoire of human T cell receptor alpha chain variable region genes in mature T lymphocytes.

1986 ◽  
Vol 164 (1) ◽  
pp. 90-103 ◽  
Author(s):  
Y Yoshikai ◽  
N Kimura ◽  
B Toyonaga ◽  
T W Mak
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Common Mechanism ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Human T Cell ◽  
Alpha Gene ◽  
Receptor Alpha Chain ◽  
Cell Receptor Alpha

24 human T cell receptor alpha chain messages have been examined by cDNA sequence analysis and Southern blot. The data indicate that there are approximately 40 alpha chain T cell receptor variable gene segments, which can be divided into 12 families. Comparison of the J gene segments from the cDNAs to previously determined germline J alpha sequences places the number of J alpha gene segments over 21, and indicates their number to be approximately 55. Identical nucleotide sequences in independent isolates of V alpha and J alpha gene segments indicate that hypermutation may not be a common mechanism for the expansion of diversity in these genes, and suggest that the major source of diversity within the alpha chain repertoire is a result of recombinational joinings between germline V alpha and J alpha sequences, combined with imprecise junctional joining. Analysis of the V regions of these alpha chain messages reveals the presence of three domains of hypervariability roughly analogous to the CDR1, CDR2, and CDR3 regions of immunoglobulin.

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