Limited plasticity in T cell recognition of modified T cell receptor contact residues in MHC class II bound peptides

2005 ◽  
Vol 42 (3) ◽  
pp. 355-364 ◽  
Author(s):  
E HAAN ◽  
J WAGENAARHILBERS ◽  
R LISKAMP ◽  
E MORET ◽  
M WAUBEN
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
Class Ii ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Contact Residues

scholarly journals Major histocompatibility complex-specific recognition of Mls-1 is mediated by multiple elements of the T cell receptor.

1993 ◽  
Vol 177 (2) ◽  
pp. 433-442 ◽  
Author(s):  
D L Woodland ◽  
H P Smith ◽  
S Surman ◽  
P Le ◽  
R Wen ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
Class Ii ◽  
Cell Recognition ◽  
Fine Specificity ◽  
T Cell Recognition ◽  
Histocompatibility Complex ◽  
Mhc Haplotype

We have recently shown that recognition of the mouse mammary tumor virus 9-associated superantigen (vSAG-9) by murine V beta 17+ T cells is strongly influenced by the major histocompatibility complex (MHC) class II haplotype of the presenting cells, resulting in a form of MHC-restricted recognition. This finding was unexpected, because T cell recognition of another well-characterized retroviral superantigen, minor lymphocyte-stimulating antigen 1 (Mls-1), had been shown to be independent of the MHC haplotype of the presenting cell. To determine whether recognition of vSAG-9 and Mls-1 is fundamentally different, we undertook an extensive analysis of MHC haplotype influences on vSAG-9 and Mls-1 recognition by panels of T cell hybridomas. Our results show that, although most hybridomas recognized Mls-1 regardless of the MHC haplotype of the presenting cells, as previously described by others, some hybridomas exhibited unique patterns of MHC fine specificity. Thus, T cell recognition of vSAG-9 and Mls-1 is not fundamentally different, but the apparent differences can be explained in terms of frequency. The MHC fine specificity of individual Mls-1-reactive hybridomas was influenced by both V beta and non-V beta T cell receptor (TCR) elements. First, the influence of the V beta element was apparent from the observation that V beta 8.2+ hybridomas were significantly more MHC specific in their recognition of Mls-1 than V beta 8.1 hybridomas. Second, a role for the TCR alpha chain was implicated from the distinct patterns of fine specificity of Mls-1 reactivity among a panel of transgenic hybridomas that expressed an identical beta chain (V beta 8.1D beta 2J beta 2.3C beta 2). Sequence analysis revealed that junctional residues of the TCR alpha chain and/or V alpha/J alpha combinations influenced the MHC haplotype fine specificity for Mls-1. Third, D beta J beta influences were implicated, in that the transgenic hybridomas expressed distinctive patterns of Mls-1 fine specificity not represented among V beta 8.1+ nontransgenic hybridomas. The findings that T cell recognition of endogenous superantigen is MHC specific, and that this specificity correlates with non-V beta elements of the TCR, support the hypothesis that there is a direct interaction between the TCR and either polymorphic residues of the MHC class II molecule or haplotype-specific dominant peptides presented by class II.

Contribution of T-cell receptor-contacting and peptide-binding residues of the class II molecule HLA-DR4 Dw10 to serologic and antigen-specific T-cell recognition

1991 ◽  
Vol 32 (2) ◽  
pp. 110-118 ◽  
Author(s):  
Linda D. Barber ◽  
Vineeta Bal ◽  
Jonathan R. Lamb ◽  
Robyn E. O'Hehir ◽  
Janet Yendle ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Peptide Binding ◽  
Cell Receptor ◽  
Class Ii ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Binding Residues

scholarly journals In vivo clonal dominance and limited T-cell receptor usage in human CD4+ T-cell recognition of house dust mite allergens.

1993 ◽  
Vol 90 (17) ◽  
pp. 8214-8218 ◽  
Author(s):  
L. R. Wedderburn ◽  
R. E. O'Hehir ◽  
C. R. Hewitt ◽  
J. R. Lamb ◽  
M. J. Owen
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
House Dust ◽  
House Dust Mite ◽  
Cell Receptor ◽  
Cd4 T Cell ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Dust Mite

Vulnerability of allografts to rejection by MHC class II-restricted T-cell receptor transgenic mice1

2003 ◽  
Vol 75 (8) ◽  
pp. 1415-1422 ◽  
Author(s):  
Major K. Lee ◽  
Xiaolun Huang ◽  
Beth P. Jarrett ◽  
Daniel J. Moore ◽  
Niraj M. Desai ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
Class Ii

scholarly journals MHC class II engagement inhibits CD99-induced apoptosis and up-regulation of T cell receptor and MHC molecules in human thymocytes and T cell line

FEBS Letters ◽  
2003 ◽  
Vol 546 (2-3) ◽  
pp. 379-384 ◽  
Author(s):  
Min Kyung Kim ◽  
Yoon-La Choi ◽  
Min Kyung Kim ◽  
Seok-Hyung Kim ◽  
Eun Young Choi ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Line ◽  
T Cell Receptor ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
Class Ii ◽  
Mhc Molecules ◽  
Induced Apoptosis

scholarly journals Cysteinylation of MHC Class II Ligands: Peptide Endocytosis and Reduction Within APC Influences T Cell Recognition

2001 ◽  
Vol 166 (7) ◽  
pp. 4543-4551 ◽  
Author(s):  
M. Azizul Haque ◽  
John W. Hawes ◽  
Janice S. Blum
Keyword(s):  
T Cell ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Cell Recognition ◽  
T Cell Recognition

Structural basis for the recognition of mutant self by a tumor-specific, MHC class II–restricted T cell receptor

2007 ◽  
Vol 8 (4) ◽  
pp. 398-408 ◽  
Author(s):  
Lu Deng ◽  
Ries J Langley ◽  
Patrick H Brown ◽  
Gang Xu ◽  
Leslie Teng ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
Class Ii ◽  
Structural Basis

T Cell Recognition of Flanking Residues of Murine Invariant Chain-Derived CLIP Peptide Bound to MHC Class II

1998 ◽  
Vol 188 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Marisa F. Naujokas ◽  
Scott Southwood ◽  
Sonya J. Mathies ◽  
Ettore Appella ◽  
Alessandro Sette ◽  
...  
Keyword(s):  
T Cell ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Invariant Chain ◽  
Cell Recognition ◽  
T Cell Recognition

T cell receptor recognition of MHC class II-bound peptide flanking residues results in altered Vβ usage and profound functional dependency

1997 ◽  
Vol 56 ◽  
pp. 6-7
Author(s):  
Richard T. Carson ◽  
Kate M. Vignali ◽  
David L. Woodland ◽  
Dario A.A. Vignali
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
Class Ii ◽  
Functional Dependency ◽  
Receptor Recognition
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